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Association of hypertension with the severity and fatality of SARS-CoV-2 infection: A meta-analysis

  • Jingqi Zhang (a1), Jing Wu (a1), Xiaohua Sun (a2), Hong Xue (a3), Jianguo Shao (a3), Weihua Cai (a3), Yang Jing (a1), Ming Yue (a4) and Chen Dong (a1)...

Abstract

Hypertension is a common comorbidity in COVID-19 patients. However, the association of hypertension with the severity and fatality of COVID-19 remain unclear. In the present meta-analysis, relevant studies reported the impacts of hypertension on SARS-CoV-2 infection were identified by searching PubMed, Elsevier Science Direct, Web of Science, Wiley Online Library, Embase and CNKI up to 20 March 2020. As the results shown, 12 publications with 2389 COVID-19 patients (674 severe cases) were included for the analysis of disease severity. The severity rate of COVID-19 in hypertensive patients was much higher than in non-hypertensive cases (37.58% vs 19.73%, pooled OR: 2.27, 95% CI: 1.80–2.86). Moreover, the pooled ORs of COVID-19 severity for hypertension vs. non-hypertension was 2.21 (95% CI: 1.58–3.10) and 2.32 (95% CI: 1.70–3.17) in age <50 years and ⩾50 years patients, respectively. Additionally, six studies with 151 deaths of 2116 COVID-19 cases were included for the analysis of disease fatality. The results showed that hypertensive patients carried a nearly 3.48-fold higher risk of dying from COVID-19 (95% CI: 1.72–7.08). Meanwhile, the pooled ORs of COVID-19 fatality for hypertension vs. non-hypertension was 6.43 (95% CI: 3.40–12.17) and 2.66 (95% CI: 1.27–5.57) in age <50 years and ⩾50 years patients, respectively. Neither considerable heterogeneity nor publication bias was observed in the present analysis. Therefore, our present results provided further evidence that hypertension could significantly increase the risks of severity and fatality of SARS-CoV-2 infection.

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Copyright

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Corresponding author

Author for correspondence: Chen Dong, E-mail: cdong@suda.edu.cn; Ming Yue, E-mail: njym08@163.com

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These authors contributed equally to this work.

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References

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Association of hypertension with the severity and fatality of SARS-CoV-2 infection: A meta-analysis

  • Jingqi Zhang (a1), Jing Wu (a1), Xiaohua Sun (a2), Hong Xue (a3), Jianguo Shao (a3), Weihua Cai (a3), Yang Jing (a1), Ming Yue (a4) and Chen Dong (a1)...

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