Hostname: page-component-8448b6f56d-tj2md Total loading time: 0 Render date: 2024-04-24T07:03:46.924Z Has data issue: false hasContentIssue false
  • English
  • Français

Antibody status to influenza A/Singapore/1/57(H2N2) in Finland during a period of outbreaks caused by H3N2 and H1N1 subtype viruses

Published online by Cambridge University Press:  19 October 2009

R. Pyhälä
R. Pyhälä
Affiliation:
National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki 28, Finland
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The incidence of haemagglutination inhibition (HI) antibody (titre ≥ 12) to influenza A/Singapore/1/57(H2N2) in sera collected from a Finnish population in the summer of 1981 was 58%. Subjects born after 1968 were essentially seronegative, and a comparable low HI antibody status was also recorded among the elderly, lowest being in people born during the period 1901–10. A small increase in antibody titre to the H2N2 virus was observed in the different age groups after infections with the H3N2, but not the H1N1, subtype influenza A viruses. The heterotypic response, which could be due to HI or NA antibodies, was restricted almost exclusively to subjects already exhibiting this antibody in acute phase sera. Moreover, the anamnestic boosting was not as strong as that described in earlier studies from samples collected at the beginning of the present era of H3N2 viruses.At population level, the HI antibody status to H2N2 was about the same at the beginning and end of the follow-up period which covered eight epidemic seasons. The results are discussed with respect to the doctrine of ‘original antigenic sin’ and to the threat of re-emergence of the H2N2 viruses.

Type
Research Article
Information
Journal of Hygiene , Volume 95 , Issue 2 , October 1985 , pp. 437 - 445
Copyright
Copyright © Cambridge University Press 1985

References

REFERENCES

Al-Khayatt, R., Jennings, R. & Potter, C. W. (1984). Interpretation of responses and protective levels of antibody against attenuated influenza A viruses using single radial hemolysis. Journal of Hygiene 92, 301–312.CrossRefGoogle Scholar
Angklova, L. A. & Shvartsman, Y. S. (1982). Original antigenic sin to influenza in rats. Immunology 46, 183–188.Google Scholar
Chakraverty, P., Cunningham, P. & Pereira, M. S. (1982). The return of the historic influenza A H1N1 virus and its impact on the population of the United Kingdom. Journal of Hygiene 89, 80–100.CrossRefGoogle ScholarPubMed
Dowdle, W. R., Marine, W. M., Coleman, M. & Knez, V. (1972). Haemagglutinin relationships of Hong Kong (H3) and Asian (112) influenza strains delineated by antigen-specific recom binants. Journal of General Virology 16, 127–134.CrossRefGoogle Scholar
Fox, J. P., Coonky, M. K., Hall, C. K. & Foy, R. M. (1982). Influenzavirus infections in Seattle families, 1075–1070. II. Pattern of infection in invaded households and relation of age and prior antibody to occurrence of infection and related illness. American Journal of Epidemiology 116, 228–242.CrossRefGoogle ScholarPubMed
Francis, T. Jr, Davenport, F. M. & Hennesy, A. V. (1953). A serological recapitulation of human infection with different strains of influenza virus. Transactions of the Association of American Physicians 66, 231–239.Google ScholarPubMed
Marine, W. M. & Thomas, J. E. (1979). Antigenic memory to influenza A viruses in man determined by monovalcnt vaccines. Postgraduate Medical Journal 55, 98–108.CrossRefGoogle Scholar
Marine, W. M.Workman, W. M. & Webster, R. G. (1969). Immunological interrelationships of Hong Kong, Asian and Equi-2 influenza viruses in man. Bulletin of the World Health Organization 41, 475–482.Google ScholarPubMed
Masurel, N. & Heijtink, R. A. (1983). Recycling of H1N1 influenza A virus in man – a haemagglutinin antibody study. Journal of Hygiene 90, 307–402.Google Scholar
Masurel, N. & Marine, W. M. (1973). Recycling of Asian and Hong Kong influenza A virus hemagglutinins in man. American Journal of Epidemiology 97, 44–49.CrossRefGoogle ScholarPubMed
Mathur, U., Bentley, D. W., Hall, C. H., Roth, F. K. & Douglas, R. G. Jr, (1981). Influenza A/Brazil/78 (H 1 Nl) infection in the elderly. American Review of Respiratory Disease 123, 633–635.Google Scholar
Morita, M., Suto, T. & Ishida, N. (1972). Antigenic memory in man in response to sequential infections with influenza A virus. Journal of Infectious Diseases 126, 61–68.CrossRefGoogle Scholar
Mulder, J. & Masurel, N. (1958). Pre-epidemic antibody against 1957 strain of Asiatic influenza in serum of older people living in the Netherlands. Lancet i, 810.CrossRefGoogle Scholar
Palese, P. & Young, J. F. (1983). Molecular epidemiology of influenza virus. In Genetics of Influenza Viruses (ed. Palese, P. and Kingsbury, D. W.), pp. 321–336. Wien: Springer-Verlag.CrossRefGoogle Scholar
Pyhälä, R. (1978). Antibodies to influenza A viruses of the H1N1 subtype: age-dependency and effect of recent infections with H3N2 viruses. FEMS Microbiology Letters 3, 165–167.CrossRefGoogle Scholar
Pyhälä, R. (1979). H1N1 influenza and old people. FEMS Microbiology Letters 6, 175–176.CrossRefGoogle Scholar
Pyhälä, R. & Aho, K. (1975). Serum HI antibody and protection against influenza: a follow-up survey at community level of three epidemics caused by different H3N2 variants. International Journal of Epidemiology 4, 127–129.CrossRefGoogle ScholarPubMed
Pyhälä, R. & Aho, K. (1981). Seroepidemiology of H1N1 influenza: the infection and re-infection rate in winter 1978–79. Journal of Hygiene 86, 27–33.CrossRefGoogle ScholarPubMed
Pyhälä, R. & Aho, K. (1982). Seroepidemiology of H1N1 influenza: the range of the affected population is widening. Medical Biology 60, 328–332.Google ScholarPubMed
Robinson, R. Q. & Dowdle, W. R. (1969). Influenza viruses. In Diagnostic Procedures for Viral and Iiickellsial Infections (ed. Lennette, E. H. and Schmidt, H. K.), pp. 426–427. New York: American Public Health Association.Google Scholar
Slepushkin, A. N., Ritova, V. V., Feklisova, L. V., Fedorova, G. I., Obrosova-Serova, N. P., Safonova, E. S., Kupryashina, L. M., Molibog, E. V., Slepushkin, V. A. & Zhdanov, V. M. (1984). Results of a two-year study of humoral immunity to influenza A and B viruses in children under the age of 14 years in Moscow and its suburbs. Bulletin of the World Health Organization 62, 75–82.Google Scholar
Tauraso, N. M., Gleckman, R., Pedreira, F. A., Sabbaj, J., Yahwak, R. & Madoff, M. A. (1969). Effect of dosage and route of inoculation upon antigenicity of inactivated influenza virus vaccine (Hong Kong strain) in man. Bulletin of the World Health Organization 41, 507–510.Google ScholarPubMed
Webster, R. G. (1972). On the origin of pandemic influenza viruses. Current Topics in Microbiology and Immunology 59, 75–105.Google ScholarPubMed
Webster, R. G., Laver, W. G. & Air, G. M. (1983). Antigenic variation among typo A influenza viruses. In Genetics of Influenza Viruses (ed. Palese, P. and Kingsbury, D. W.), pp. 127–168. Wien: Springer-Verlag.CrossRefGoogle Scholar