Hostname: page-component-76fb5796d-dfsvx Total loading time: 0 Render date: 2024-04-27T07:44:14.960Z Has data issue: false hasContentIssue false
  • English
  • Français

Antibody response and reactions to aqueous influenza vaccine, simple emulsion vaccine and multiple emulsion vaccine. A report to the Medical Research Council Committee on influenza and other respiratory virus vaccines*

Published online by Cambridge University Press:  15 May 2009

P. J. Taylor ,
Christine L. Miller ,
T. M. Pollock ,
F. T. Perkins  and
M. A. Westwood
P. J. Taylor
Affiliation:
T. U. C. Centenary Institute of Occupational Health
Christine L. Miller
Affiliation:
Epidemiological Research Laboratory, Public Health Laboratory Service
T. M. Pollock
Affiliation:
Epidemiological Research Laboratory, Public Health Laboratory Service
F. T. Perkins
Affiliation:
Medical Research Council, London
M. A. Westwood
Affiliation:
Medical Research Council, London
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Influenza vaccines prepared with a mineral oil adjuvant induce a substantial and durable antibody response. However, vaccines containing mineral oil in simple emulsion (water-in-oil emulsion) sometimes produce persistent local reactions (Medical Research Council, 1964). The development of a redispersed ‘multiple’ emulsion in which antigen is incorporated as an oil-in-water emulsion starting from an original water-in-oil emulsion was described by Herbert (1965). Such multiple emulsion vaccine has a lesser viscosity than simple emulsions and might therefore produce a substantial antibody response with fewer reactions. In this investigation a comparison has been made of the antibody response and short-term vaccination reactions after aqueous influenza vaccine, influenza vaccine containing a mineral oil in simple emulsion, and influenza vaccine containing mineral oil in multiple emulsion.

Type
Research Article
Information
Journal of Hygiene , Volume 67 , Issue 3 , September 1969 , pp. 485 - 490
Copyright
Copyright © Cambridge University Press 1969

References

Berlin, B. S. (1962). Tests for biologic safety of arlacel A. Ann. Allergy 20, 472.Google Scholar
Herbert, W. J. (1965). Multiple emulsions: a new form of mineral antigen adjuvant. Lancet ii. 771.CrossRefGoogle Scholar
Medical Research Council (1964). Clinical trials of oil-adjuvant influenza vaccines. 1960–3. Br. med. J. ii, 267.Google Scholar
World Health Organization (1953). Expert Committee on influenza: First report. Tech. Rep. Ser. Wld Hlth Org. no. 64.Google Scholar