Skip to main content Accessibility help
×
×
Home

Antibiotic sensitivities of Neisseria meningitidis isolates from patients and carriers in Greece

  • G. Tzanakaki (a1), C. C. Blackwell (a2), J. Kremastinou (a3), C. Kallergi (a4), G. Kouppari (a4) and D. M. Weir (a2)...

Summary

Usage of antibiotics in southern Europe is less well regulated than in northern countries. The proportion (48%) of meningococci in Spain insensitive to penicillin (MIC ≥ 0·1 mg/l) prompted this investigation of antibiotic sensitivities of isolates from Greek patients with meningitis (31) and carriers (47 school-children and 472 recruits). The agar dilution method was used to determine MIC to penicillin G (PN), sulphamethoxazole (SU), rifampicin (RF), cefaclor (CF) and ciprofloxacin (CP).

The proportion of isolates insensitive to PN was 48% for isolates from patients, 19% from school-children and 36·6% from recruits. Resistance to SU (MIC ≥ 16 mg/l) was found in 16% of those from patients, 10·6% from children and 40% from recruits. None of the isolates from patients was resistant to RF (≥ 1 mg/l) but 6% of those from carriers were. Resistance to CF (≥ 4 mg/l) was found in 9·2% of patient isolates, 6·4% from children and 23·7% from recruits. All isolates except one were sensitive to CP (MIC range < 0·0015–0·125 mg/l).

Resistances to PN, SU and RF were analysed by serogroup, serotype and subtype of the bacteria. The proportion of resistant isolates showed some variation between different areas of Greece, but it was not statistically significant.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Antibiotic sensitivities of Neisseria meningitidis isolates from patients and carriers in Greece
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Antibiotic sensitivities of Neisseria meningitidis isolates from patients and carriers in Greece
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Antibiotic sensitivities of Neisseria meningitidis isolates from patients and carriers in Greece
      Available formats
      ×

Copyright

Corresponding author

*Author for correspondence

References

Hide All
1.Saez-Nieto, JA, Fontanals, D, Garcia de, Jalon J et al. , Isolation of Neisseria meningitidis strains with increase of penicillin minimal inhibitory concentration. Epidemiol Infect 1987; 99: 463–9.
2.Saez-Nieto, JA, Vazquez, JA, Macros, C. Meningococci moderately resistant to penicillin. Lancet 1990; ii: 54.
3.Botha, P. Penicillin-resistant Neisseria meningitidis in southern Africa. Lancet 1988; i: 54.
4.Sutcliffe, EM, Jones, DM, El-Sheikh, S et al. , Penicillin-insensitive meningococci in the UK. Lancet 1988; i: 657–8.
5.Jones, DM, Sutcliffe, EM. Meningococci with reduced susceptibility to penicillin. Lancet 1990; i: 863–4.
6.Blackwell, CC, Tzanakaki, G, Kremastinou, J et al. , Factors affecting carriage of Neisseria meningitidis among Greek military recruits. Epidemiol Infect 1992; 108: 441–8.
7.AAC working party. Phillips, I, Andrews, J, Bint, AJ et al. , Breakpoints in in vitro antibiotic sensitivity testing. J Antimicrob Chemother 1988; 21: 701–10.
8.Young, HY. Identification and penicillinase testing of Neisseria gonorrhoeae from primary isolation cultures on MNYC medium. J Clin Microbiol 1978; 7: 247–50.
9.Abdillahi, H, Poolman, JT. Whole-cell ELISA for typing Neisseria meningitidis with monoclonal antibodies. J Med Microbiol 1987; 48: 367–71.
10.Cartwright, Kav, Stuart, JM, Jones, DM, Noah, ND. The Stonehouse survey: nasopharyngeal carriage of meningococci and Neisseria lactamica. Epidemiol Infect 1987; 99: 591601.
11.Poolman, JT, Jonsdóttir, K, Jones, DM, Lind, I, Frøholm, O, Zanen, HC. Meningococcal serotypes and serogroup B disease in Northwest Europe. Lancet 1986; ii: 555–8.
12.Tzanakaki, G, Mavromati, L, Tzelepi, E et al. , Serological classification in relation to auxotypes, plasmid contents, and susceptibility to antimicrobials of PPNG and non-PPNG strains isolated in Greece. Genitour Med 1989; 65: 171–6.
13.Gaunt, PM, Lambert, BE. Single dose ciprofloxacin for eradication of pharyngeal carriage of Neisseria meningitidis. J Antimicrob Chemother 1988; 21: 489–96.
14.Knapp, JS, Johnson, SR, Zenilman, JH et al. , High-level tetracycline resistance resulting from TetM in strains of Neisseria spp., Kingella denitrificans and Eikenella corrodens. Antimicrob Agents Chemother 1988; 32: 765–7.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed