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Antibiotic resistance in Escherichia coli causing generalized infections in chickens in the UK in 1982: the relationship between the results of in vitro and in vivo furazolidone sensitivity tests

Published online by Cambridge University Press:  19 October 2009

H. Williams Smith  and
M. A. Lovell
H. Williams Smith
Affiliation:
Houghton Poultry Research Station, Houghton, Huntingdon, Cambridgeshire, PE17 2DA
M. A. Lovell
Affiliation:
Houghton Poultry Research Station, Houghton, Huntingdon, Cambridgeshire, PE17 2DA
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Compared with a similar survey conducted ten years previously, a survey conducted in 1982, eleven years after the implementation of legislation forbidding the routine use of feeds containing ‘therapeutic’ antibiotics, revealed a decreased incidence of resistance to tetracyclines, furazolidone and sulphonamides in Escherichia coli strains causing generalized infections in chickens in the UK; the decrease was particularly marked in the case of tetracycline resistance, 17·9% of strains in 1982 being resistant to this antibiotic compared with 31·2% in 1972.

Giving furazolidone to groups of chickens inoculated intramuscularly with O2:K1 strains of E. coli of differing degrees of furazolidone sensitivity indicated that great care is required in the performance and interpretation of laboratory tests for sensitivity to this antibiotic. Infections caused by strains that required as little as 1·25 μg/ml of furazolidone to inhibit their multiplication in laboratory tests responded poorly to furazolidone treatment; those that were inhibited by less responded well, better than to treatment with tetrac3rcline, chloramphenicol. ampicillin or trimethoprim.

Type
Research Article
Information
Journal of Hygiene , Volume 93 , Issue 3 , December 1984 , pp. 445 - 453
Copyright
Copyright © Cambridge University Press 1984

References

Glover, S. W. (1968). In Experiments in Microbial Genetics (ed. Clowes, R. C. and Hayes, W.), p. 17. Oxford and Edinburgh: Blackwell Scientific Publications.Google Scholar
Harry, E. G. (1964). A study of 119 outbreaks of coli septicaemia in broiler flocks. Veterinary Record 77, 241–245.Google Scholar
Heller, E. D. & Smith, H. Williams (1973). The incidence of antibiotic resistance and other characteristics amongst Escherichia coli strains causing fatal infection in chickens: the utilization of these characteristics to study the epidemiology of the infection. Journal of Hygiene 71, 771–781.Google Scholar
Miles, A. A. & Misra, S. S. (1938). The estimation of the bactericidal power of blood. Journal of Hygiene 38, 732–749.Google Scholar
Reed, L. J. & Muench, H. (1938). A simple method of estimating fifty per cent end points. American Journal of Hygiene 27, 493–497.Google Scholar
Report (1969). Report of the Joint Committee on the Use of Antibiotics in Animal Husbandry and Veterinary Medicine. London: H.M.S.O.Google Scholar
Sarffe, L. D., McCracken, G. H. Jr, Schiffer, M. S., Glode, M. P., Robbins, J. B., Orskov, I. & Orskov, F. (1975). Epidemiology of Escherichia coli K1 in healthy and diseased new-borns. Lancet i, 1099–1104.CrossRefGoogle Scholar
Smith, H. Williams (1980). Antibiotic-resistant Escherichia coli in market pigs in 1956–1979: the emergence of organisms with plasmid-borne trimethoprim resistance. Journal of Hygiene 84, 467–477.CrossRefGoogle Scholar
Smith, H. Williams & Lovell, M. A. (1981). Escherichia coli resistant to tetracylines in the faeces of UK chickens and pigs in 1980. Journal of Hygiene 87, 477–483.CrossRefGoogle Scholar
Smith, H. Williams, Tucker, J. F. & Lovell, M. (1981). Furazolidone resistance in Salmonella gallinarum: the relationship between in vitro and in vivo determinations of resistance. Journal of Hygiene 87, 71–81.CrossRefGoogle ScholarPubMed
Sojka, W. J. & Carnaghan, R. B. A. (1961). Escherichia coli infection in poultry. Research in Veterinary Science 2, 340–352.CrossRefGoogle Scholar