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An unusual plaque variant of rubella virus

Published online by Cambridge University Press:  15 May 2009

Janine J. Gould ,
Gwenneth D. Laurence  and
M. Butler
Janine J. Gould
Affiliation:
Wellcome Research Laboratories, Beckenham, Kent, and University of Surrey, Guildford, Surrey
Gwenneth D. Laurence
Affiliation:
Wellcome Research Laboratories, Beckenham, Kent, and University of Surrey, Guildford, Surrey
M. Butler
Affiliation:
Wellcome Research Laboratories, Beckenham, Kent, and University of Surrey, Guildford, Surrey
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Summary

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In a comparative study of 24 different rubella virus strains, all but three formed small plaques in RK 13 cell cultures; of these one was the vaccine strain HPV-77, one was isolated from a congenitally infected infant, and the third was recovered from an adult who contracted severe rubella while handling this congenital strain. Whereas the plaque size of the vaccine strain was stable after further passage in cell culture, the plaque size of the other two rapidly diminished when the virus was passed in monkey kidney cells, and one of them was also reduced by passage in RK 13 cells. Cell culture passage of the typical small plaque strains did not result in altered plaque size.

Type
Research Article
Information
Journal of Hygiene , Volume 70 , Issue 1 , March 1972 , pp. 49 - 53
Copyright
Copyright © Cambridge University Press 1972

References

REFERENCES

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