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An outbreak of serogroup B:15:P1.16 meningococcal disease, Frederiksborg county, Denmark, 1987–9

Published online by Cambridge University Press:  15 May 2009

S. Samuelsson ,
P. Ege ,
L. Berthelsen  and
I. Lind
S. Samuelsson
Affiliation:
Department of Epidemiology, Statens Seruminstitut, DK-2300 Copenhagen,
P. Ege
Affiliation:
Institution of Medical Officers of Health, Frederiksborg County, Denmark
L. Berthelsen
Affiliation:
Neisseria Department, and,
I. Lind
Affiliation:
Neisseria Department, and,
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Epidemiological features of an outbreak of group B:15:P1.16 meningococcal disease (MD) in Frederiksborg country, Denmark, 1987–9, were investigated. The study comprised 149 cases notified during the outbreak and the two preceding years; 115 were confirmed by the isolation of Neisseria meningitidis. In 1989 the incidence had increased to 14·1 per 100 000 population. Among group B strains, B:15:P1.16 accounted for 80% (77/97). The overall mortality rate was 10% (15/149). Regarding cases due to group B:15:P1.16 strains a significant time-space clustering, which exclusively occurred within the 10–19 years age group, was demonstrated. The link between cases within clusters was indirect or unknown, except for ten patients with contact to one particular school. The prophylactic measures used included administration of rifampicin to household contacts. During the outbreak the proportion of secondary cases was high (6–15%). All secondary cases occurred outside the household indicating that the household had been protected.

Type
Research Article
Information
Epidemiology & Infection , Volume 108 , Issue 1 , February 1992 , pp. 19 - 30
Copyright
Copyright © Cambridge University Press 1992

References

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