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An outbreak of meningococcal disease in Stonehouse: planning and execution of a large-scale survey

  • J. M. Stuart (a1), K. A. V. Cartwright (a2), D. M. Jones (a3), N. D. Noah (a4), R. J. Wall (a5), C. Caroline Blackwell (a6), A. E. Jephcott (a7) and I. R. Ferguson (a8)...

Summary

In November 1986 a large-scale survey was undertaken in the Gloucestershire town of Stonehouse during an outbreak of meningococcal disease due to group B type 15 subtype Pl. 16 sulphonamide-resistant strains. There were 15 cases in Stonehouse residents during the 4 years from April 1983, an annual attack rate of 56·5 per 100000. Four secondary cases occurred despite rifampicin prophylaxis. The objectives of this community survey were to investigate patterns of meningococcal carriage, transmission and immunity and to determine the proportion of non-secretors of blood group antigens in the Stonehouse population find amongst meningococcal carriers. A total of 6237 subjects participated including 75% of the 6635 Stonehouse residents. Over 97% of the participants provided all three of the requested specimens – nasopharyngeal swabs, saliva and blood samples.

The co-operation between the many organizations involved in the detailed preliminary planning was instrumental in the success of the survey; in particular the value of effective collaboration between Departments of Community Medicine and Microbiology and of the Public Health Laboratory Service network of laboratories in undertaking investigations of this size and type was clearly demonstrated.

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References

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Blackwell, C. C., Jonsdottir, K., Hanson, M., Todd, W. T. A., Chaudhuri, A. K. R., Mathew, B., Brettle, R. P. & Weir, D. M. (1986). Non-secretion of ABO antigens predisposing to infection by Neisseria meningitidis and Streptococcus pneumoniae. Lancet ii, 284285.
Cartwright, K. A. V., Stuart, J. M., Jones, D. M. & Noah, N. D. (1987). The Stonehouse survey: nasopharyngeal carriage of meningococci and Neisseria lactamica. Epidemiology and Infection 99, 591601.
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An outbreak of meningococcal disease in Stonehouse: planning and execution of a large-scale survey

  • J. M. Stuart (a1), K. A. V. Cartwright (a2), D. M. Jones (a3), N. D. Noah (a4), R. J. Wall (a5), C. Caroline Blackwell (a6), A. E. Jephcott (a7) and I. R. Ferguson (a8)...

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