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An agglutinogen common to certain strains of lactose and non-lactose-fermenting coliform bacilli

Published online by Cambridge University Press:  15 May 2009

Lord Stamp  and
Doris M. Stone
Lord Stamp
Affiliation:
From The British Postgraduate Medical SchoolandThe Emergency Public Health Laboratory, Sector IX
Doris M. Stone
Affiliation:
From The British Postgraduate Medical SchoolandThe Emergency Public Health Laboratory, Sector IX
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1. Certain strains of lactose and non-lactose-fermenting coliform bacilli have been found to possess a common agglutinogen. This antigen is found in both motile and non-motile smooth strains and appears to be distinct from ‘H’, ‘O’ and rough antigens, and from the X antigen described by Topley & Ayrton. In certain respects it seems to resemble the Vi antigen of Felix & Pitt, notably in the inhibitory effect it exerts on ‘O’ agglutination. It is, however, not associated with virulence and is of relatively wide distribution.

2. The strains, when inoculated into rabbits, stimulate the production to high titre of an agglutinin which can be absorbed out completely by any one of the strains.

3. Subculture of the strains under certain conditions results in the loss of the antigen and the development of specific variants.

4. Agglutinins to these strains have been found in certain diagnostic sera and may prove a possible source of error, particularly if slide agglutination is relied on for identification.

We take this opportunity of expressing our thanks to Prof. G. S. Wilson for the loan of Bact. typhi-murium ‘X’ antiserum.

Type
Research Article
Information
Journal of Hygiene , Volume 43 , Issue 4 , January 1944 , pp. 266 - 272
Copyright
Copyright © Cambridge University Press 1944

References

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