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Adenovirus type 8 keratoconjunctivitis – an outbreak and its treatment with topical human fibroblast interferon

  • Sheena Reilly (a1), B. J. Dhillon (a2), Kamona M. Nkanza (a2), Annette M. D'Souza (a2), N. Taylor (a2), Sandra J. Hobbs (a3), A Freke (a3) and A. P. C. H. Roome (a3)...

Summary

An outbreak of keratoconjunctivitis is described which involved at least 186 people; adenovirus type 8 was identified in 50 of the cases. Topical human fibroblast interferon was assessed in a double-blind, placebo-controlled study in which 34 patients participated. Seventeen of the 34 trial patients yielded adenovirus type 8; three were infected with adenovirus type 7. The outbreak was curtailed by control of infection measures: principally careful hand-washing by medical personnel between cases and by discouraging attendance of new cases at the Eye Infirmary. Consequently the trial numbers are small. In addition there was a wide interpatient variation in the severity of infection. Therefore it was not possible to make any statistically valid conclusions concerning the recovery rate of patients receiving interferon or placebo.

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References

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Adenovirus type 8 keratoconjunctivitis – an outbreak and its treatment with topical human fibroblast interferon

  • Sheena Reilly (a1), B. J. Dhillon (a2), Kamona M. Nkanza (a2), Annette M. D'Souza (a2), N. Taylor (a2), Sandra J. Hobbs (a3), A Freke (a3) and A. P. C. H. Roome (a3)...

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