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Analgesic effects of botulinum toxin A: a randomized, placebo-controlled clinical trial

  • Shane Barwood (a1), Charles Baillieu (a1), Roslyn Boyd (a1), Kate Brereton (a2), Janette Low (a2), Gary Nattrass (a3) and H Kerr Graham (a3)...

Abstract

Postoperative pain in children with spastic cerebral palsy (CP) is often attributed to muscle spasm and is difficult to manage using opiates and benzodiazepines. Adductor-release surgery to treat or prevent hip dislocation in children with spastic CP is frequently performed and is often accompanied by severe postoperative pain and spasm. A double-blinded, randomized, placebo-controlled clinical trial of 16 patients (mean age 4.7 years) with a mainly spastic type of CP (either diplegic or quadriplegic in distribution) was used to test the hypothesis that a significant proportion of postoperative pain is secondary to muscle spasm and, therefore, might be reduced by a preoperative chemodenervation of the target surgical muscle by intramuscular injection of botulinum toxin A (BTX/A). Compared with the placebo, BTX/A was found to be associated with a reduction in mean pain scores of 74% (P<0.003), a reduction in mean analgesic requirements of approximately 50% (P<0.005), and a reduction in mean length of hospital admission of 33% (P<0.003). It was concluded that an important component of postoperative pain in the patient population is due to muscle spasm and this can be managed effectively by preoperative injection with BTX/A. These findings may have implications for the management of pain secondary to muscle spasm in other clinical settings.

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Corresponding author

The Hugh Williamson Gait Analysis Laboratory, Flemington Road, Parkville 3052, Victoria, Australia. E-mail: grahamk@cryptic.rch.unimelb.edu.au

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Analgesic effects of botulinum toxin A: a randomized, placebo-controlled clinical trial

  • Shane Barwood (a1), Charles Baillieu (a1), Roslyn Boyd (a1), Kate Brereton (a2), Janette Low (a2), Gary Nattrass (a3) and H Kerr Graham (a3)...

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