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Predictive haematological and serum biomarkers for canine endurance exercise

Published online by Cambridge University Press:  05 January 2011

Sarah B. Love ,
Michael S. Davis ,
Carla Goad ,
Keith Murphy ,
Douglas B. Aichele  and
Theresa W. Fossum
Sarah B. Love*
Affiliation:
Veterinary Internal Medicine of Alaska, LLCFairbanks, AK99706, USA
Michael S. Davis
Affiliation:
Department of Physiological Sciences, Oklahoma State University, Stillwater, OK74078, USA
Carla Goad
Affiliation:
Department of Statistics, Oklahoma State University, StillwaterOK74078, USA
Keith Murphy
Affiliation:
Department of Genetics and Biochemistry, Clemson University, Clemson, SC29634, USA
Douglas B. Aichele
Affiliation:
Department of Mathematics, Oklahoma State University, Stillwater, OK74078, USA
Theresa W. Fossum
Affiliation:
Texas Institute for Preclinical Studies, Texas A & M University, TX, USA
*
*Corresponding author: sblovedvm@gmail.com
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Abstract

Successful completion of endurance exercise is facilitated by conditioning that enhances the capacity of the cardiovascular and musculoskeletal systems to maintain a high level of aerobic activity. Insufficiency or disease in these systems may be diagnosed using routine haematology and serum chemistry testing. Pre-race blood samples obtained from 82 endurance-trained sled dogs were used to test the hypothesis that common haematological and serum chemistry values could identify subjects with occult disease, decreasing the likelihood of their finishing a multi-day exercise challenge. Multivariate logistic regression was used to identify the combinations of specific biomarkers that best predicted the eventual outcome of the exercise challenge for an individual dog. This analysis constructed six different predictive formulas. In all cases, the formulae contained the pre-race values for creatine kinase and some measurement of erythrocyte abundance. When a probability of 0.4 was used as a cut-off value, all dogs with values below the cut-off did not complete the race. These results suggest that in a population of healthy, aerobically conditioned subjects, routine clinical biomarkers can be used to identify subjects unsuited to performance for endurance exercise.

Keywords

endurance exercisehaematologybiochemistry
Type
Research Paper
Information
Comparative Exercise Physiology , Volume 7 , Issue 3 , August 2010 , pp. 109 - 115
Copyright
Copyright © Cambridge University Press 2011

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References

1Hinchcliff, KW (1996). Performance failure in Alaskan sled dogs: biochemical correlates. Research in Veterinary Science 61: 271–272.Google Scholar
2Long, RD (1993). Treatment of common injuries in endurance racing sled dogs. Compendium on Continuing Education for the Practicing Veterinarian 15: 434–437.Google Scholar
3Kutner, MH, Nachtsheim, CJ and Neter, J (2004). Applied Linear Regression Models. 4th edn.Irwin, New York: McGraw-Hill.Google Scholar
4Davis, MS, Davis, WC, Ensign, WY, Hinchcliff, KW, Holbrook, TC and Williamson, KK (2008). Effects of training and strenuous exercise on hematologic values and peripheral blood leukocyte subsets in racing sled dogs. Journal of the American Veterinary Medical Association 232: 873–878.CrossRefGoogle ScholarPubMed
5Lee, JA, Hinchcliff, KW, Piercy, RJ, Schmidt, KE and Nelson, S Jr (2004). Effects of racing and nontraining on plasma thyroid hormone concentrations in sled dogs. Journal of the American Veterinary Medical Association 224: 226–231.CrossRefGoogle ScholarPubMed
6Piercy, RJ, Hinchcliff, KW, Morley, PS, Disilvestro, RA, Reinhart, GA, Nelson, SL, et al. (2001). Association between vitamin E and enhanced athletic performance in sled dogs. Medicine and Science in Sports and Exercise 33: 826–833.CrossRefGoogle ScholarPubMed
7Blot, S (2000). Disorders of the skeletal muscles. In: Ettinger, SJ and Feldman, EC (eds) Textbook of Veterinary Internal Medicine. 5th edn.Philadelphia: WB Saunders.Google Scholar
8Hinchcliff, KW, Olson, J, Crusberg, C, Kenyon, J, Long, R, Royle, W, et al. (1993). Serum biochemical changes in dogs competing in a long-distance sled race. Journal of the American Veterinary Medical Association 202: 401–405.CrossRefGoogle Scholar
9McKenzie, E, Holbrook, T, Williamson, K, Royer, C, Valberg, S, Hinchcliff, K, et al. (2005). Recovery of muscle glycogen concentrations in sled dogs during prolonged exercise. Medicine and Science in Sports and Exercise 37: 1307–1312.CrossRefGoogle ScholarPubMed
10McKenzie, EC, Jose-Cunilleras, E, Hinchcliff, KW, Holbrook, TC, Royer, C, Payton, ME, et al. (2007). Serum chemistry alterations in Alaskan sled dogs during five successive days of prolonged endurance exercise. Journal of the American Veterinary Medical Association 230: 1486–1492.CrossRefGoogle ScholarPubMed
11Dennis, MM, Nelson, SN, Cantor, GH, Mosier, DA, Blake, JE and Basaraba, RJ (2008). Assessment of necropsy findings in sled dogs that died during Iditarod Trail sled dog races: 23 cases (1994–2006). Journal of the American Veterinary Medical Association 232: 564–573.CrossRefGoogle ScholarPubMed
12Piercy, RJ, Hinchcliff, KW, Morley, PS, DiSilvestro, RA, Reinhart, GA, Nelson, SL, et al. (2001). Vitamin E and exertional rhabdomyolysis during endurance sled dog racing. Neuromuscular Disorders 11: 826–833.CrossRefGoogle ScholarPubMed
13Hinchcliff, KW, Shaw, LC, Vukich, NS and Schmidt, KE (1998). Effect of distance traveled and speed of racing on body weight and serum enzyme activity of sled dogs competing in a long-distance race. Journal of the American Veterinary Medical Association 213: 639–644.CrossRefGoogle Scholar
14Rifai, N, Douglas, PS, O'Toole, M, Rimm, E and Ginsburg, GS (1999). Cardiac troponin T and I, echocardiographic (correction of electrocardiographic) wall motion analyses, and ejection fractions in athletes participating in the Hawaii Ironman Triathlon. The American Journal of Cardiology 83: 1085–1089.CrossRefGoogle ScholarPubMed
15McKeever, KH, Schurg, WA and Convertino, VA (1985). Exercise training-induced hypervolemia in greyhounds: role of water intake and renal mechanisms. The American Journal of Physiology 248: R422–R425.Google Scholar
16Davis, MS, Willard, M, Nelson, S, Mandsager, RE, McKiernan, BC, Mansell, JK, et al. (2003). Prevalence of gastric lesions in racing Alaskan sled dogs. Journal of Veterinary Internal Medicine 17: 311–314.CrossRefGoogle ScholarPubMed
17Royer, CM, Willard, MD, Williamson, KK, Steiner, JM, Williams, DA and Davis, MS (2005). Exercise stress, intestinal permeability, and gastric ulceration in racing Alaskan sled dogs. Equine and Comparative Exercise Physiology 2: 53–59.Google Scholar
18Latimer, KA, Mahaffey, EA and Prasse, KW (2003). Duncan and Prasse's Veterinary Laboratory Medicine: Clinical Pathology. 4th edn.Ames, IA: Iowa State Press.Google Scholar