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White Matter Hyperintensities and Their Association With Suicidally in Major Affective Disorders: A Meta-Analysis of Magnetic Resonance Imaging Studies

Published online by Cambridge University Press:  07 November 2014

Maria Conceição Grangeon ,
Camila Seixas ,
Lucas C. Quarantini ,
Angela Miranda-Scippa ,
Maurizio Pompili ,
David C. Steffens ,
Amy Wenzel ,
Acioly L. T. Lacerda  and
Irismar Reis de Oliveira
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Abstract

Introduction: Individuals who have deep and periventricular white matter hyperintensities may have a higher risk for suicidal behavior. There are mixed results in the literature regarding whether unipolar or bipolar patients who have attempted suicide have more deep white matter hyperintensities (DWMH) or periventricular hyperintensities (PVH) relative to those who have no history of suicide attempts.

Methods: A meta-analysis of studies examining white matter hyperintensities (WMH) in mood disorder patients with and without a history of suicide attempts was performed.

Results: Four studies, including a total of 173 patients who attempted suicide and 183 who did not attempt suicide, were included. A significantly higher number of attempters were found to have WMH than non-attempters. Unipolar depressed patients who had attempted suicide had 1.9 times more DWMH and 2.1 times more PVH than those who did not. Bipolar patients who had attempted suicide had 5.4 times more PVH than those who had not. Taken together, unipolar and bipolar patients who had attempted suicide had 2.8 times more DWMH and 4.5 times more PVH than those who had never attempted suicide.

Type
Original Research
Information
CNS Spectrums , Volume 15 , Issue 6 , June 2010 , pp. 375 - 381
Copyright
Copyright © Cambridge University Press 2010

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