In recent years, the incidence rate of mixed depression among college students has increased, which is related to the increase in employment pressure and student life pressure. With the development of the situation, introducing mental health education into university teaching has become an important research direction. Combining the causes of student illness, research will integrate innovation and entrepreneurship education with mental health education in the treatment of mixed-type depression patients.

200 college students were randomly selected as the survey subjects, and 20 mixed-type depression college students were obtained through the survey. According to the random number table, the patients are divided into a control group and an intervention group, with 10 cases in each group. There was no significant difference in gender, age, and HAMD score between the two groups of patients (P>0.05). The control group received routine treatment, while the intervention group received a combination of innovation and entrepreneurship education and mental health education on this basis. The treatment cycle is 3 months.

The study used SPSS23.0 statistical software to analyze the experimental data. The results showed that after intervention treatment, the HAMD score, SAS anxiety score, and SDS depression score of both groups of patients decreased (P<0.05). The score of the intervention group was significantly lower than that of the control group (P<0.05).

Innovation and entrepreneurship education can alleviate students’ employment pressure and provide new paths for employment. Combining it with mental health education for the treatment of mixed-type depression patients can effectively alleviate their symptoms such as depression and anxiety.