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Schizophrenia Risk and Paternal Age: A Potential Role for De Novo Mutations in Schizophrenia Vulnerability Genes

Published online by Cambridge University Press:  07 November 2014

Dolores Malaspina ,
Alan Brown ,
Deborah Goetz ,
Nelly Alia-Klein ,
Jill Harkavy-Friedman ,
Susan Harlap  and
Shmuel Fennig
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Abstract

How schizophrenia (SZ) is maintained at roughly 1% of the population despite diminished reproduction is one puzzle currently facing researchers. De novo mutations were first proposed over half a century ago as a source for new SZ genes. Current evidence linking advancing paternal age to SZ risk makes revisiting this hypothesis important. Advancing paternal age is the major source of new mutations in the human population. This article will examine potential mechanisms whereby parental age may impact new mutations, as well as review recent data supporting such a hypothesis.

Type
Feature Article
Information
CNS Spectrums , Volume 7 , Issue 1 , January 2002 , pp. 26 - 29
Copyright
Copyright © Cambridge University Press 2002

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