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The Paradox of Quetiapine in Obsessive-Compulsive Disorder

Published online by Cambridge University Press:  07 November 2014

Constantin Tranulis ,
Stéphane Potvin ,
Martin Gourgue ,
Gérard Leblanc ,
Adham Mancini-Marïe  and
Emmanuel Stip
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Abstract

Schizophrenia and obsessive-compulsive disorder (OCD) have historical, clinical, and epidemiological links. The clinical use of atypical neuroleptics (ie, dual serotonin-dopamine antagonists) to treat both conditions sheds a new light on them. We report the first two cases of obsessive-compulsive symptoms (OCS) induced by quetiapine in schizophrenia patients. A case of successful augmentation by quetiapine in refractory OCD is also presented. A review of the literature on OCS induced by atypical neuroleptics follows. This paradoxically induced OCD symptomology in schizophrenia patients administered atypical neuroleptics is discussed from new pathophysiological and clinical perspectives. The discussion emphasizes the prognostic implications of OCS in schizophrenia and available therapies for this comorbidity.

Type
Case Report
Information
CNS Spectrums , Volume 10 , Issue 5 , May 2005 , pp. 356 - 361
Copyright
Copyright © Cambridge University Press 2005

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