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Neurobiological features of binge eating disorder

  • Iris M. Balodis (a1), Carlos M. Grilo (a1) (a2) (a3) and Marc N. Potenza (a1) (a3) (a4) (a5)


Biobehavioral features associated with binge-eating disorder (BED) have been investigated; however, few systematic reviews to date have described neuroimaging findings from studies of BED. Emerging functional and structural studies support BED as having unique and overlapping neural features as compared with other disorders. Neuroimaging studies provide evidence linking heightened responses to palatable food cues with prefrontal areas, particularly the orbitofrontal cortex (OFC), with specific relationships to hunger and reward-sensitivity measures. While few studies to date have investigated non-food-cue responses; these suggest a generalized hypofunctioning in frontostriatal areas during reward and inhibitory control processes. Early studies applying neuroimaging to treatment efforts suggest that targeting neural function underlying motivational processes may prove important in the treatment of BED.


Corresponding author

*Address for correspondence: Iris M. Balodis, Department of Psychiatry, Yale University, 1 Church Street, New Haven, CT 06511, USA. (Email:


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This was supported by P20 DA027844, K24 DK070052, CASAColumbia and the National Center for Responsible Gaming.



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Neurobiological features of binge eating disorder

  • Iris M. Balodis (a1), Carlos M. Grilo (a1) (a2) (a3) and Marc N. Potenza (a1) (a3) (a4) (a5)


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