1. Holsboer, F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology. 2000;23:477–501.
2. Heim, C, Newport, DJ, Heit, S, et al. Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. JAMA. 2000;284:592–597.
3. Coplan, JD, Andrews, MW, Rosenblum, LA, et al. Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders. Proc Natl Acad Sci U S A. 1996;93:1619–1623.
4. Sapolsky, RM. Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry. 2000;57:925–935.
5. Lopez, JF, Akil, H, Watson, SJ. Neural circuits mediating stress. Biol Psychiatry. 1999;46:1461–1471.
6. Skolnick, P. Antidepressants for the new millennium. Eur J Pharmacol. 1999;375;31–40.
7. Cotman, CW, Kahle, JS, Miller, SE, et al. Excitatory amino acid neurotransmission. In: Bloom, FE, Kupfer, DJ, eds. Psychopharmacology: The Fourth Generation of Progress. New York, NY: Raven; 1995:75–85.
8. Krystal, JH, D'Souza, CD, Petrakis, IL, et al. NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders. Harvard Rev Psychiatry. 1999;7:125–143.
9. Marek, GJ, Aghajanian, GK. Excitation of interneurons in piriform cortex by 5-hydroxytryptamine (5-HT): blockade by MDL 100,907, a highly selective 5-HT2A antagonist. Eur J Pharmacol. 1994;259:137–141.
10. Maragakis, NJ, Rothstein, JD. Glutamate transporters in neurologic disease. Arch Neurol. 2001;58:365–370.
11. Brauner-Osborne, H, Egebjerb, J, Nielsen, EO, et al. Ligands for glutamate receptors: design and therapeutic prospects. J Med Chem. 2000;43:2609–2645.
12. Gabr, RW, Birkle, DL, Azzaro, AJ. Stimulation of the amygdala by glutamate facilitates corticotropin-releasing factor release from the median eminence and activation of the hypothalamic-pituitary-adrenal axis in stressed rats. Neuroendocrinology. 1995;62:333–339.
13. Crafty, MS, Birkle, DL. N-methyl-D-aspartate (NMDA)-mediated corticotropin-releasing factor (CRF) release in cultured rat amygdala neurons. Peptides. 1999;20:93–100.
14. Feldman, S, Weidenfeld, J. Hypothalamic mechanisms mediating glutamate effects on the hypothalamie-pituitary-adrenocortical axis. J Neural Transm. 1997:104:633–642.
15. Singewald, N, Zhou, GY, Chen, F, et al. Corticotropin-releasing factor modulates basal and stress-induced excitatory amino acid release in the locus ceruleus of conscious rats. Neurosci Lett. 1996;204:45–48.
16. McEwen, BS, Albeck, D, Cameron, H, et al. Stress and brain: a paradoxical role for adrenal steroids. In: Litwack, GD, ed. Vitamins and Hormones. San Diego, CA: Academic Press; 1995:371–402.
17. Moghaddam, B, Bolinao, ML, Stein-Behrens, B, et al. Glucocorticoids mediate the stress-induced extracellular accumulation of glutamate. Brain Res. 1994;655:251–254.
18. Gould, E, Tanapat, P. Stress and hippocampal neurogenesis. Biol Psychiatry. 1999;46:1472–1479.
19. Cameron, HA, McEwen, BS, Gould, E. Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus. J Neurosci. 1995;15:4687–4692.
20. Jacobs, BL, van Praag, H, Gage, FH. Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol Psychiatry. 2000;5:262–269.
21. Kocsis, K, Kiss, J, Gores, T, et al. Metabotropic glutamate receptor in vasopressin, CRF and VIP hypothalamic neurons. Neuroreport. 1998;9:4029–4033.
22. Mathew, SJ, Smith, ELP, Trost, RC, et al. Effects of chronic treatment with the novel metabotropic glutamate receptor agonist LY354740 in nonhuman primates: evidence for uncoupling of the HPA axis and noradrenergic system [abstract]. Young Investigators Abstract presented at American Psychiatric Association annual meeting; May 5-10, 2001; New Orleans, La.
23. Joanny, P, Steinberg, J, Oliver, C, et al. Glutamate and N-methyl-D-aspartate stimulate rat hypothalamic corticotropin-releasing factor secretion in vitro. J Neuroendocrinol. 1997;9:93–97.
24. Tokarev, D, Jezova, D. Effect of central administration of the non-NMDA receptor antagonist DNQX on ACTH and corticosterone release before and during immobilization stress. Methods Find Exp Clin Pharmacol. 1997;19:323–328.
25. Zelena, D, Makara, GB, Jezova, D. Simultaneous blockade of two glutamate receptor subtypes (NMDA and AMPA) results in stressor-specific inhibition of prolactin and corticotropin release. Neuroendocrinology. 1999;69:316–323.
26. Calabrese, JR, Bowden, CL, Sachs, GS, et al. A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group. J Clin Psychiatry. 1999;60:79–88.
27. Berman, RM, Cappiello, A, Anand, A, et al. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry. 2000;47:351–354.
28. Nowak, G, Ordway, GA, Paul, IA. Alterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims. Brain Res. 1995;675:157–164.
29. Levine, J, Panchalingam, K, Rapoport, A, et al. Increased cerebrospinal fluid glutamine levels in depressed patients. Biol Psychiatry. 2000;47:586–593.
30. Auer, DP, Putz, B, Kraft, E, et al. Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study. Biol Psychiatry. 2000;47:305–313.
31. Rosenberg, DR, MacMaster, FP, Keshavan, MS, et al. Decrease in caudate glutamatergic concentrations in pediatric obsessive compulsive disorder patients taking paroxetine. J Am Acad Child Adolesc Psych. 2000;39:1096–1103.
32. Duman, RS, Heninger, GR, Nestler, EJ. A molecular and cellular theory of depression. Arch Gen Psychiatry. 1997;54:597–606.
33. Nibuya, M, Morinobu, S, Duman, RS. Regulation of BDNF and trkB mRNA following chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci. 1995;15:7539–7547.
34. Altar, CA. Neurotrophins and depression. Trends Pharmacol Sci. 1999;20:59–61.
35. Brandoli, C, Sanna, A, De Bernardi, MA, et al. Brain-derived neurotrophic factor and basic fibroblast growth factor downregulate NMDA receptor function in cerebellar granule cells. J Neurosci. 1998;18:7953–7961.
36. Hayashi, T, Umemori, H, Mishina, M. The AMPA receptor interactions with and signals through the protein tyrosine kinase Lyn. Nature. 1999;397:72–76.
37. Caldji, C, Francis, D, Sharma, S, et al. The effects of early rearing environment on the development of GABAA and central benzodiazepine receptor levels and nov elty-induced fearfulness in the rat. Neuropsychopharmacology. 2000;22:219–229.
38. Tanaka, K, Watase, K, Mabe, T, et al. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science. 1997;276:1699–1702.