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Functional Magnetic Resonance Imaging Studies in Bipolar Disorder

  • Deborah A. Yurgelun-Todd and Amy J. Ross

Abstract

Abnormalities in brain activation using functional magnetic resonance imaging (fMRI) during cognitive and emotional tasks have been identified in bipolar disorder patients, in frontal, subcortical and limbic regions. Several studies also indicate that mood state may be differentiated by lateralization of brain activation in fronto-limbic regions. The interpretation of fMRI studies in bipolar disorder is limited by the choice of regions of interest, medication effects, comorbidity, and task performance. These studies suggest that there is a complex alteration in regions important for neural networks underlying cognition and emotional processing in bipolar disorder. However, measuring changes in specific brain regions does not identify how these neural networks are affected. New analytical techniques of fMRI data are needed in order to resolve some of these issues and identify how changes in neural networks relate to cognitive and emotional processing in bipolar disorder.

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Corresponding author

Please direct all correspondence to: Deborah A. Yurgelun-Todd, PhD, McLean Hospital Brain Imaging Center, 115 Mill Street, Belmont, MA 02478-9106; Tel: 617-855-3238, Fax: 617-855-2770; E-mail: ytodd@mclean.harvard.edu.

References

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1.Sapin, LR, Berrettini, WH, Nurnberger, JI Jr, Rothblat, LA. Mediational factors underlying cognitive changes and laterality in affective illness. Biol Psychiatry. 1987;22:979986.
2.Altshuler, LL. Bipolar disorder: are repeated episodes associated with neuroanatomic and cognitive changes? Biol Psychiatry. 1993;33:563565.
3.Sweeney, JA, Wetzler, S, Stokes, P, Kocsis, J. Cognitive functioning in depression. J Clin Psychol. 1989;45:836842.
4.Brown, GW, Moran, P. Clinical and psychosocial origins of chronic depressive episodes. I: A community survey. Br J Psychiatry. 1994;165:447456.
5.Hornak, J, Rolls, ET, Wade, D. Face and voice expression identification in patients with emotional and behavioural changes following ventral frontal lobe damage. Neuropsychologia. 1996;34:247261.
6.Kessing, LV. Cognitive impairment in the euthymic phase of affective disorder. Psychol Med. 1998;28:10271038.
7.Murphy, FC, Sahakian, BJ, Rubinsztein, JS, et al.Emotional bias and inhibitory control processes in mania and depression. Psychol Med. 1999;29:13071321.
8.Austin, MP, P, , Goodwin, GM. Cognitive deficits in depression: possible implications for functional neuropathology. Br J Psychiatry. 2001;178:200206.
9.Coffman, JA, Bornstein, RA, Olson, SC, Schwarzkopf, SB, Nasrallah, HA. Cognitive impairment and cerebral structure by MRI in bipolar disorder. Biol Psychiatry. 1990;27:11881196.
10.Joseph, R. Frontal lobe psychopathology: mania, depression, confabulation, catatonia, perseveration, obsessive compulsions, and schizophrenia. Psychiatry. 1999;62:138172.
11.Murphy, FC, Sahakian, BJ. Neuropsychology of bipolar disorder. Br J Psychiatry Suppl. 2001;41:s120s127.
12.Mayberg, HS. Limbic-cortical dysregulation: a proposed model of depression. J Neuropsychiatry Clin Neurosci. 1997;9:471481.
13.Davidson, RJ. Anterior electrophysiological asymmetries, emotion, and depression: conceptual and methodological conundrums. Psychophysiology. 1998;35:607614.
14.Blumberg, HP, Stern, E, Martinez, D, et al.Increased anterior cingulate and caudate activity in bipolar mania. Biol Psychiatry. 2000;48:10451052.
15.Goodwin, FK, Jamison, KR. Manic-Depressive Psychoses. New York, NY: Oxford University Press, 1990.
16.Adler, CM, Holland, SK, Schmithorst, V, Tuchfarber, MJ, Strakowski, SM. Changes in neuronal activation in patients with bipolar disorder during performance of a working memory task. Bipolar Disord. 2004;6:540549.
17.Strakowski, SM, Adler, CM, Holland, SK, Mills, N, DelBello, MP. A preliminary FMRI study of sustained attention in euthymic, unmedicated bipolar disorder. Neuropsychopharmacology 2004;29:17341740.
18.Strakowski, SM, Adler, CM, Holland, SK, Mills, NP, DelBello, MP, Eliassen, JC. Abnormal FMRI brain activation in euthymic bipolar disorder patients during a counting Stroop interference task. Am J Psychiatry. 2005;162:16971705.
19.Gruber, SA, Rogowska, J, Yurgelun-Todd, DA. Decreased activation of the anterior cingulate in bipolar patients: an fMRI study. J Affect Disord. 2004;82:191201.
20.Frangou, S. The Maudsley Bipolar Disorder Project. Epilepsia. 2005;46(suppl 4):1925.
21.Monks, PJ, Thompson, JM, Bullmore, ET, et al.A functional MRI study of working memory task in euthymic bipolar disorder: evidence for task-specific dysfunction. Bipolar Disord. 2004;6:550564.
22.Blumberg, HP, Leung, HC, Skudlarski, P, et al.A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Arch Gen Psychiatry. 2003;60:601609.
23.Blumberg, HP, Martin, A, Kaufman, J, et al.Frontostriatal abnormalities in adolescents with bipolar disorder: preliminary observations from functional MRI. Am J Psychiatry. 2003;160:13451347.
24.Chang, K, Adleman, NE, Dienes, K, Simeonova, DI, Menon, V, Reiss, A. Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: a functional magnetic resonance imaging investigation. Arch Gen Psychiatry. 2004;61:781792.
25.Cummings, JL. Frontal-subcortical circuits and human behavior. Arch Neurol. 1993;50:873880.
26.Caligiuri, MP, Brown, GG, Meloy, MJ, et al.An fMRI study of affective state and medication on cortical and subcortical brain regions during motor performance in bipolar disorder. Psychiatry Res. 2003;123:171182.
27.Caligiuri, MP, Brown, GG, Meloy, MJ, et al.A functional magnetic resonance imaging study of cortical asymmetry in bipolar disorder. Bipolar Disord. 2004;6:183196.
28.Yurgelun-Todd, DA, Gruber, SA, Kanayama, G, Killgore, WD, Baird, AA, Young, AD. fMRI during affect discrimination in bipolar affective disorder. Bipolar Disord. 2000;2(3 pt 2):237248.
29.Mitchell, RL, Elliott, R, Barry, M, Cruttenden, A, Woodruff, PW. Neural response to emotional prosody in schizophrenia and in bipolar affective disorder. Br J Psychiatry. 2004;184:223230.
30.Lawrence, NS, Williams, AM, Surguladze, S, et al.Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression. Biol Psychiatry. 2004;55:578587.
31.Elliott, R, Ogilvie, A, Rubinsztein, JS, Calderon, G, Dolan, RJ, Sahakian, BJ. Abnormal ventral frontal response during performance of an affective go/no go task in patients with mania. Biol Psychiatry. 2004;55:11631170.
32.Lennox, BR, Jacob, R, Calder, AJ, Lupson, V, Bullmore, ET. Behavioural and neurocognitive responses to sad facial affect are attenuated in patients with mania. Psychol Med. 2004;34:795802.
33.Chen, CH, Lennox, B, Jacob, R, et al.Explicit and implicit facial affect recognition in manic and depressed states of bipolar disorder: a functional magnetic resonance imaging study. Biol Psychiatry. 2006;59:3139.
34.Malhi, GS, Lagopoulos, J, Ward, PB, et al.Cognitive generation of affect in bipolar depression: an fMRI study. Eur J Neurosci. 2004;19:741754.
35.Malhi, GS, Lagopoulos, J, Sachdev, P, PB, , Ivanovski, B, Parker, GB. Cognitive generation of affect in hypomania: an fMRI study. Bipolar Disord. 2004;6:271285.
36.Elliott, R, Rubinsztein, JS, Sahakian, BJ, Dolan, RJ. The neural basis of mood-congruent processing biases in depression. Arch Gen Psychiatry. 2002;59:597604.
37.Rajkowska, G, Halaris, A, Selemon, LD. Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder. Biol Psychiatry. 2001;49:741752.
38.Ongur, D, Drevets, WC, Price, JL. Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci U S A. 1998;95:1329013295.
39.Haldane, M, Frangou, S. New insights help define the pathophysiology of bipolar affective disorder: neuroimaging and neuropathology findings. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28:943960.
40.Strakowski, SM, Delbello, MP, Adler, CM. The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings. Mol Psychiatry. 2005;10:105116.
41.Brambilla, P, Nicoletti, M, Sassi, RB, et al.Corpus callosum signal intensity in patients with bipolar and unipolar disorder. J Neurol Neurosurg Psychiatry. 2004;75:221225.
42.Brambilla, P, Nicoletti, MA, Sassi, RB, et al.Magnetic resonance imaging study of corpus callosum abnormalities in patients with bipolar disorder. Biol Psychiatry. 2003;54:12941297.
43.Schlaepfer, TE, Harris, GJ, Tien, AY, et al.Decreased regional cortical gray matter volume in schizophrenia. Am J Psychiatry. 1994;151:842848.
44.Zipursky, RB, Seeman, MV, Bury, A, Langevin, R, Wortzman, G, Katz, R. Deficits in gray matter volume are present in schizophrenia but not bipolar disorder. Schizophr Res. 1997;26:8592.
45.Davis, KA, Kwon, A, Cardenas, VA, Deicken, RF. Decreased cortical gray and cerebral white matter in male patients with familial bipolar I disorder. J Affect Disord. 2004;82:475485.
46.Kieseppa, T, van Erp, TG, Haukka, J, et al.Reduced left hemispheric white matter volume in twins with bipolar I disorder. Biol Psychiatry. 2003;54:896905.
47.Strakowski, SM, Wilson, DR, Tohen, M, Woods, BT, Douglass, AW, Stoll, AL. Structural brain abnormalities in first-episode mania. Biol Psychiatry 1993;33:602609.
48.Ahn, KH, Lyoo, IK, Lee, HK, et al.White matter hyperintensities in subjects with bipolar disorder. Psychiatry Clin Neurosci. 2004;58:516521.
49.Altshuler, LL, Curran, JG, Hauser, P, Mintz, J, Denicoff, K, Post, R. T2 hyperintensities in bipolar disorder: magnetic resonance imaging comparison and literature meta-analysis. Am J Psychiatry. 1995;152:11391144.
50.Aylward, EH, Roberts-Twillie, JV, Barta, PE, et al.Basal ganglia volumes and white matter hyperintensities in patients with bipolar disorder. Am J Psychiatry. 1994;151:687693.
51.Woods, BT, Yurgelun-Todd, D, Mikulis, D, Pillay, SS. Age-related MRI abnormalities in bipolar illness: a clinical study. Biol Psychiatry. 1995;38:846847.
52.Dupont, RM, Jernigan, TL, Butters, N, et al.Subcortical abnormalities detected in bipolar affective disorder using magnetic resonance imaging. Clinical and neuropsychological significance. Arch Gen Psychiatry. 1990;47:5559.
53.Adler, CM, Holland, SK, Schmithorst, V, et al.Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study. Bipolar Disord. 2004;6:197203.
54.Beyer, JL, Taylor, WD, Macfall, JR, et al.Cortical white matter microstructural abnormalities in bipolar disorder. Neuropsychopharmacology. 2005;30:22252229.
55.Haznedar, MM, Roversi, F, Pallanti, S, et al.Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses. Biol Psychiatry. 2005;57:733742.
56.Drevets, WC, Price, JL, Simpson, JR Jr, et al.Subgenual prefrontal cortex abnormalities in mood disorders. Nature. 1997;386:824827.
57.Yurgelun-Todd, DA, Waternaux, CM, Cohen, BM, Gruber, SA, English, CD, Renshaw, PF. Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production. Am J Psychiatry. 1996;153:200205.
58.Curtis, VA, Bullmore, ET, Brammer, MJ, et al.Attenuated frontal activation during a verbal fluency task in patients with schizophrenia. Am J Psychiatry. 1998;155:10561063.
59.Volz, H, Gaser, C, Hager, F, et al.Decreased frontal activation in schizophrenics during stimulation with the continuous performance test–a functional magnetic resonance imaging study. Eur Psychiatry. 1999;14:1724.
60.Barch, DM, Carter, CS, Braver, TS, et al.Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia. Arch Gen Psychiatry. 2001;58:280288.
61.Callicott, JH, Bertolino, A, Mattay, VS, et al.Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb Cortex. 2000;10:10781092.
62.Sharma, T. Insights and treatment options for psychiatric disorders guided by functional MRI. J Clin Invest. 2003;112:1018.
63.Manoach, DS. Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings. Schizophr Res. 2003;60:285298.
64.Elliott, R, Baker, SC, Rogers, RD, et al.Prefrontal dysfunction in depressed patients performing a complex planning task: a study using positron emission tomography. Psychol Med. 1997;27:931942.
65.George, MS, Ketter, TA, Parekh, PI, et al.Blunted left cingulate activation in mood disorder subjects during a response interference task (the Stroop). J Neuropsychiatry Clin Neurosci. 1997;9:5563.
66.Harvey, PO, Fossati, P, Pochon, JB, et al.Cognitive control and brain resources in major depression: an fMRI study using the n-back task. Neuroimage. 2005;26:860869.
67.Hugdahl, K, Rund, BR, Lund, A, et al.Brain activation measured with fMRI during a mental arithmetic task in schizophrenia and major depression. Am J Psychiatry. 2004;161:286293.
68.Okada, G, Okamoto, Y, Morinobu, S, Yamawaki, S, Yokota, N. Attenuated left prefrontal activation during a verbal fluency task in patients with depression. Neuropsychobiology. 2003;47:2126.
69.Wagner, G, Sinsel, E, Sobanski, T, et al.Cortical inefficiency in patients with unipolar depression: an event-related fMRI study with the Stroop task. Biol Psychiatry. 2006 (in press).
70.Curtis, VA, Dixon, TA, Morris, RG, et al.Differential frontal activation in schizophrenia and bipolar illness during verbal fluency. J Affect Disord. 2001;66:111121.

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Functional Magnetic Resonance Imaging Studies in Bipolar Disorder

  • Deborah A. Yurgelun-Todd and Amy J. Ross

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