Skip to main content Accessibility help
×
Home

Does obesity and diabetes mellitus metastasize to the brain? “Metaboptosis” and implications for drug discovery and development

  • Roger S. McIntyre (a1) (a2) (a3) (a4), Carola Rong (a1), Rodrigo B. Mansur (a1) (a3) and Elisa Brietzke (a1)
  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Does obesity and diabetes mellitus metastasize to the brain? “Metaboptosis” and implications for drug discovery and development
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Does obesity and diabetes mellitus metastasize to the brain? “Metaboptosis” and implications for drug discovery and development
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Does obesity and diabetes mellitus metastasize to the brain? “Metaboptosis” and implications for drug discovery and development
      Available formats
      ×

Abstract

  • An abstract is not available for this content so a preview has been provided below. To view the full text please use the links above to select your preferred format.

Copyright

Corresponding author

*Address correspondence to: Roger S. McIntyre, MD, FRCPC, University Health Network; Brain and Cognition Discovery Foundation, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada. (Email: Roger.McIntyre@uhn.ca)

References

Hide All
1.McIntyre, RS. A vision for drug discovery and development: Novel targets and multilateral partnerships. Adv Ther. 2014; 31(3): 245246.
2.Wen, Z, Christian, KM, Song, H, et al. Modeling psychiatric disorders with patient-derived iPSCs. Curr Opin Neurobiol. 2016; 36: 118127.
3.O’shea, KS, McInnis, MG. Neurodevelopmental origins of bipolar disorder: iPSC models. Mol Cell Neurosci. 2016; 73: 6383.
4.Villa, RF, Ferrari, F, Bagini, L, et al. Mitochondrial energy metabolism of rat hippocampus after treatment with the antidepressants desipramine and fluoxetine. Neuropharmacology. 2017; 121: 3038.
5.Srivastava, R, Faust, T, Ramos, A, et al. Dynamic changes of the mitochondria in psychiatric illnesses: New mechanistic insights from human neuronal models. Biol Psychiatry. 2018; 83: 751760. doi: 10.1016/j.biopsych.2018.01.007.
6.Pietruczuk, K, Lisowska, KA, Grabowski, K, et al. Proliferation and apoptosis of T lymphocytes in patients with bipolar disorder. Sci Rep. 2018; 8(1): 3327.
7.Neth, BJ, Craft, S. Insulin resistance and Alzheimer’s disease: Bioenergetic linkages. Front Aging Neurosci. 2017; 9: 345.
8.Zheng, K, Wang, N, Shen, Y, et al. Pro-apoptotic effects of microRNA-365 on retinal neurons by targeting IGF-1 in diabetic rats: An in vivo and in vitro study. J Diabetes Investig. 2018; 9(5): 10411051. doi: 10.1111/jdi.12815.
9.Kalaivani, A, Uddandrao, VS, Parim, B, et al. Reversal of high fat diet-induced obesity through modulating lipid metabolic enzymes and inflammatory markers expressions in rats. Arch Physiol Biochem. 2018; 124: 17.
10.Mansur, RB, Brietzke, E, McIntyre, RS. Is there a ‘metabolic-mood syndrome’? A review of the relationship between obesity and mood disorders. Neurosci Biobehav Rev. 2015; 52: 89104.
11.Mansur, RB, Lee, Y, Zhou, AJ, et al. Determinants of cognitive function in individuals with type 2 diabetes mellitus: A meta-analysis. Ann Clin Psychiatry. 2018; 30(1): 3850.
12.McIntyre, RS, Soczynska, JK, Konarski, JZ, et al. Should depressive syndromes be reclassified as ‘metabolic syndrome type II’? Ann Clin Psychiatry. 2007; 19(4): 257264.
13.Skvarc, DR, Dean, OM, Byrne, LK, et al. The effect of N-acetylcysteine (NAC) on human cognition – A systematic review. Neurosci Biobehav Rev. 2017; 78: 4456.
14.Sa-Nguanmoo, P, Tanajak, P, Kerdphoo, S, et al. SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFD-induced obese rats. Toxicol Appl Pharmacol. 2017; 333: 4350.
15.Colle, R, de Larminat, D, Rotenberg, S, et al. Pioglitazone could induce remission in major depression: A meta-analysis. Neuropsychiatr Dis Treat. 2017; 13: 916.
16.Colle, R, de Larminat, D, Rotenberg, S, et al. PPAR-γ agonists for the treatment of major depression: A review. Pharmacopsychiatry. 2017; 50(2): 4955.
17.McIntyre, RS, Soczynska, JK, Woldeyohannes, HO, et al. A randomized, double-blind, controlled trial evaluating the effect of intranasal insulin on neurocognitive function in euthymic patients with bipolar disorder. Bipolar Disord. 2012; 14(7): 697706.
18.Craft, S, Claxton, A, Baker, LD, et al. Effects of regular and long-acting insulin on cognition and Alzheimer’s disease biomarkers: A pilot clinical trial. J Alzheimer Dis. 2017; 57(4): 13251334.
19.Claxton, A, Baker, L, Hanson, A, et al. Long-acting intranasal insulin detemir improves working memory for adults with mild cognitive impairment or early-stage Alzheimer’s dementia. Alzheimers Dementia: J Alzheimers Assoc. 2013; 9(4): P657.
20.Mansur, RB, Ahmed, J, Cha, DS, et al. Liraglutide promotes improvements in objective measures of cognitive dysfunction in individuals with mood disorders: A pilot, open-label study. J Affect Disord. 2017; 207: 114120.
21.Mansur, RB, Lee, Y, Subramaniapillai, M, et al. Cognitive dysfunction and metabolic comorbidities in mood disorders: A repurposing opportunity for glucagon-like peptide 1 receptor agonists? Neuropharmacology. 2018; 136: 335–342. doi: 10.1016/j.neuropharm.2018.01.048.
22.Phillips, AG, Geyer, MA, Robbins, TW. Effective use of animal models for therapeutic development in psychiatric and substance use disorders. Biol Psychiatry. 2018; 83: 915–923. doi: 10.1016/j.biopsych.2018.01.014.

Does obesity and diabetes mellitus metastasize to the brain? “Metaboptosis” and implications for drug discovery and development

  • Roger S. McIntyre (a1) (a2) (a3) (a4), Carola Rong (a1), Rodrigo B. Mansur (a1) (a3) and Elisa Brietzke (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.