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Behavioral Effects of Clomipramine on Prepubertal Boys With Autistic Disorder and Severe Mental Retardation

Published online by Cambridge University Press:  07 November 2014

James Robert Brasić ,
Jacqueline Y. Barnett ,
Brian B. Sheitman ,
R. Todd Lafargue ,
S. Kowalik ,
Diana Kaplan ,
Margaret Owen Tsaltas ,
Raheela Ahmad ,
Robert H. Nadrich  and
Maria de Fatima Mendonça
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Abstract

In an open nonblind clinical trial, clomipramine was administered to five previously medicated prepubertal boys with autistic disorder and severe mental retardation unmanageable due to behavior and motor problems. Although all five boys initially displayed marked behavioral symptom reduction, they developed behavioral newotoxicity necessitating discontinuation of clomipramine for all five and immediate hospitalization for three. Serious adverse effects included increased seizure frequency and symptoms of a serotonin syndrome. Our findings indicate that clomipramine enhances adaptive behavior and produces serious adverse effects in severely retarded autistic children whose symptoms were complicated by dyskinesias.

Type
Feature Articles
Information
CNS Spectrums , Volume 3 , Issue 10 , December 1998 , pp. 39 - 46
Copyright
Copyright © Cambridge University Press 1998

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