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Psychopharmacology of Obsessive-Compulsive Disorder

Published online by Cambridge University Press:  07 November 2014


Obsessive-compulsive disorder (OCD) was thought to be a rather rare disorder and little attention was focused on investigations of the disorder until the first placebo-controlled studies reported efficacy. In 1980 three pivotal papers were published: Montgomery reported that clomipramine was effective in OCD without concomitant depression, and Thoren et al and Marks et al reported that clomipramine was effective in OCD with varying amounts of concomitant depression. These results opened the floodgates of psychopharmacological research and encouraged a more aggressive research program aimed at providing sufficient data for OCD to be recognized as a treatable condition.

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Copyright © Cambridge University Press 1998

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