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Neuroimaging in OCD: Clinical Implications

Published online by Cambridge University Press:  07 November 2014


An overview is provided regarding neuroimaging in obsessive-compulsive disorder (OCD). The author emphasizes convergent research results across various experimental paradigms and their implications for neurobiological models of OCD. The article concludes with an outline of future considerations that highlights emerging concepts and techniques. This work was intended to serve as a concise summary of the field, and thus to provide a springboard for discussion about this topic at the upcoming International Obsessive Compulsive Disorder Conference.

Supplement Monograph
Copyright © Cambridge University Press 1998

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1.Rauch, SL, Renshaw, PF. Clinical neuroimaging in psychiatry. Harvard Rev Psychiatry. 1995;2:297312.Google Scholar
2.Baxter, LR, Schwartz, JM, Guze, BH, et al.Neuroimaging in obsessive-compulsive disorder: seeking the mediating neuroanatomy. In: Jenike, MA, Baer, L, Minichiello, WE, eds. Obsessive Compulsive Disorder: Theory and Management. 2nd ed. Chicago: Year Book Medical Publishers; 1990:167188.Google Scholar
3.Rauch, SL, Jenike, MA. Neural mechanisms of obsessive-compulsive disorder. Curr Rev Mood Anxiety Disord. 1997;1:8494.Google Scholar
4.Behar, K, Rapoport, JL, Berg, CJ, et al.Computerized tomography and neuropsychological test measures in adolescents with obsessive-compulsive disorder. Am J Psychiatry. 1984;141:363368.Google Scholar
5.Insel, TR, Donnely, EF, Lalakea, ML, et al.Neurological and neuropsychological studies of patients with obsessive-compulsive disorder. Biol Psychiatry. 1983;18:741751.Google Scholar
6.Kellner, CH, Jolley, RR, Holgate, RC, et al. Brain MRI in obsessive-compulsive disorder. Psychiatry Res. 1991;36:4549.Google Scholar
7.Luxenberg, JS, Swedo, SE, Flament, MF, et al.Neuroanatomical abnormalities in obsessive-compulsive disorder detected with quantitative X-ray computed tomography. Am J Psychiatry. 1988;145:10891093.Google Scholar
8.Aylward, EH, Harris, GJ, Hoehn-Saric, R, et al.Normal caudate nucleus in obsessive-compulsive disorder assessed by quantitative neuroimaging. Arch Gen Psychiatry. 1996;53:577584.Google Scholar
9.Jenike, MA, Breiter, HC, Baer, L, et al.Cerebral structural abnormalities in obsessive-compulsive disorder: a quantitative morphometric magnetic resonance imaging study. Arch Gen Psychiatry. 1996;53:625632.Google Scholar
10.Robinson, D, Wu, H, Munne, RA, et al.Reduced caudate nucleus volume in obsessive-compulsive disorder. Arch Gen Psychiatry. 1995;52:393398.Google Scholar
11.Scarone, S, Colombo, C, Livian, S, et al: Increased right caudate nucleus size in obsessive compulsive disorder: detection with magnetic resonance imaging. Psychiatry Res Neuroimaging. 1992;45:115121.Google Scholar
12.O'Sullivan, R, Rauch, SL, Breiter, HC, et al.Reduced basal ganglia volumes in trichotillomania by morphometric MRI. Biol Psychiatry. 1997;42:3945.Google Scholar
13.Peterson, B, Riddle, MA, Cohen, DJ, et al.Reduced basal ganglia volumes in Tourette's syndrome using threedimensional reconstruction techniques from magnetic resonance images. Neurology. 1993;43:941949.Google Scholar
14.Singer, HS, Reiss, AL, Brown, JE, et al.Volumetric MRI changes in basal ganglia of children with Tourette's syndrome. Neurology. 1993;43:950956.Google Scholar
15.Rosenberg, DR, Keshavan, MS, O'Hearn, KM, et al.Frontostriatal measurement in treatment-naive children with obsessive-compulsive disorder. Arch Gen Psychiatry. 1997;54:824830.Google Scholar
16.Hyde, TM, Stacey, ME, Coppola, R, et al.Cerebral morphometric abnormalities in Tourette's syndrome: a quantitative MRI study of monozygotic twins. Neurology. 1995;45:11761182.Google Scholar
17.Hoehn-Saric, R, Benkelfat, C. Structural and functional brain imaging in obsessive compulsive disorder. In: Hollander, E, Zohar, J, Marazziti, D, et al, eds. Current Insights in Obsessive Compulsive Disorder. New York: John Wiley; 1994:183214.Google Scholar
18.Baxter, LR Jr, Schwartz, JM, Bergman, KS, et al.Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder. Arch Gen Psychiatry. 1992;49:681689.Google Scholar
19.Benkelfat, C, Nordahl, TE, Semple, WE, et al.Local cerebral glucose metabolic rates in obsessive-compulsive disorder: patients treated with clomipramine. Arch Gen Psychiatry. 1990;47:840848.Google Scholar
20.Perani, D, Colombo, C, Bressi, S, et al.FDG PET study in obsessive-compulsive disorder: a clinical metabolic correlation study after treatment. Br J Psychiatry. 1995;166:244250.Google Scholar
21.Schwartz, JM, Stoessel, PW, Baxter, LR, et al.Systematic changes in cerebral glucose metabolic rate after successful behavior modification. Arch Gen Psychiatry. 1996;53:109113.Google Scholar
22.Swedo, SE, Pietrini, P, Leonard, HL, et al.Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder: revisualization during pharmacotherapy. Arch Gen Psychiatry. 1992;49:690694:CrossRefGoogle ScholarPubMed
23.Breiter, HC, Rauch, SL, Kwong, KK, et al.Functional magnetic resonance imaging of symptom provocation in obsessive compulsive disorder. Arch Gen Psychiatry. 1996;53:595606.CrossRefGoogle ScholarPubMed
24.McGuire, PK, Bench, CJ, Frith, CD, et al.Functional anatomy of obsessive-compulsive phenomena. Br J Psychiatry. 1994;164:459468.Google Scholar
25.Rauch, SL, Jenike, MA, Alpert, NM, et al.Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using 150-labeled CO2 and positron emission tomography. Arch Gen Psychiatry. 1994;51:6270.Google Scholar
26.Zohar, J, Insel, T, Berman, K, et al.Anxiety and cerebral blood flow during behavioral challenge: dissociation of central from peripheral and subjective measures. Arch Gen Psychiatry. 1989;46:505510.Google Scholar
27.Rauch, SL, Savage, CR, Alpert, NM, et al.A positron emission tomographic study of simple phobic symptom provocation. Arch Gen Psychiatry. 1995;52:2028.CrossRefGoogle ScholarPubMed
28.Rauch, SL, van der Kolk, BA, Fisler, RE, et al: A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery. Arch Gen Psychiatry. 1997;53:380387.Google Scholar
29.Benkelfat, C, Bradwejn, J, Meyer, E, et al.Functional neuroanatomy of CCK4-induced anxiety in normal healthy volunteers. Am J Psychiatry. 1995;152:11801184.Google Scholar
30.Rauch, SL, Savage, CR, Brown, HD, et al: A PET investigation of implicit and explicit sequence learning. Hum Brain Mapping. 1995;3:271286.Google Scholar
31.Rauch, SL, Whalen, PJ, Savage, CR, et al.Striatal recruitment during an implicit sequence learning task as measured by functional magnetic resonance imaging. Hum Brain Mapping. 1997;5:124132.Google Scholar
32.Rauch, SL, Savage, CR, Alpert, NM, et al.Probing striatal function in obsessive compulsive disorder: a PET study of implicit sequence learning. J Neuropsychiatry. 1997;9:568573.Google ScholarPubMed
33.Rauch, SL, Whalen, PJ, Curran, T, et al.Thalamic deactivation during early implicit sequence learning: a functional MRI study. NeuroReport. 1998;9:865870.Google Scholar
34.Whalen, PJ, Bush, G, McNally, R, et al.The Digital Emotional Stroop activates anterior cingulate cortex: an fMRI study. Neuroimage. 1997;5:S121. Abstract.Google Scholar
35.Whalen, PJ, Rauch, SL, Etcoff, NL, et al.Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. J Neurosci. 1998;18:411418.CrossRefGoogle ScholarPubMed
36.Rauch, SL, Dougherty, DD, Shin, LM, et al.Neural correlates of factor-analyzed OCD symptom dimensions: a PET stucy. CNS Spectrums. In press.Google Scholar
37.Grachev, ID, Brieter, HC, Rauch, SL, et al.Structural abnormalities of frontal neocortex in obsessive-compulsive disorder. Arch Gen Psychiatry. 1998;55:181182.Google Scholar
38.Ebert, D, Speck, O, Konig, A, et al.1H magnetic resonance spectroscopy in obsessive compulsive disorder: evidence for neuronal loss in the cingulate gyrus and right striatum. Psychiatric Res: Neuroimaging. 1997;74:173176.CrossRefGoogle ScholarPubMed
39.Hollander, E, Prohovnik, I, Stein, DJ. Effects of m-CPP induced obsessions on cortical blood flow. J Neuropsychiatry. 1995;7:485490.Google Scholar
40.George, MS, ed. Transcranial magnetic stimulation: mapping and modifying brain-behavior relationships. CNS Spectrums. 1997;2.Google Scholar
41.Dager, SR, Steen, RG. Applications of magnetic resonance spectroscopy to the investigation of neuropsychiatric disorders. Neuropsychopharmacology. 1992;6:249266.Google Scholar