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Sustained-Release Drug Delivery Potential of Antibiotic–Montmorillonite Composites Prepared Using Montmorillonite Mined in Gampo, Republic of Korea

Published online by Cambridge University Press:  01 January 2024

Myungjae Kim ,
Ki-Min Roh ,
Jiwoo Kim ,
Minkyeong Seo ,
Il-Mo Kang  and
Jiwoong Kim Open the ORCID record for Jiwoong Kim [Opens in a new window]
Myungjae Kim
Affiliation:
Department of OrganicMaterials and Fiber Engineering, Soongsil University, Seoul 06978, Republic of Korea
Ki-Min Roh
Affiliation:
Advanced Geo-Materials R&D Department, Pohang Branch, Korea Institute of Geoscience and Mineral Resources, Pohang 37559, Republic of Korea Department of Nanomaterials Science and Engineering, University of Science and Technology, Daejeon 34113, Republic of Korea
Jiwoo Kim
Affiliation:
Department of OrganicMaterials and Fiber Engineering, Soongsil University, Seoul 06978, Republic of Korea
Minkyeong Seo
Affiliation:
Department of OrganicMaterials and Fiber Engineering, Soongsil University, Seoul 06978, Republic of Korea
Il-Mo Kang
Affiliation:
Advanced Geo-Materials R&D Department, Pohang Branch, Korea Institute of Geoscience and Mineral Resources, Pohang 37559, Republic of Korea
Jiwoong Kim*
Affiliation:
Department of OrganicMaterials and Fiber Engineering, Soongsil University, Seoul 06978, Republic of Korea
*
e-mail: jwk@ssu.ac.kr
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Abstract

Biocompatible drug-delivery materials are important because they provide controlled release of biologically active agents to enhance the effectiveness of medical treatments. Montmorillonite (Mnt) has been utilized in drug-delivery systems for delayed-release application because it can safely encapsulate drug molecules via intercalation reactions. The objective of the present study was to evaluate the delivery characteristics of the drug ciprofloxacin (CIP) from a composite with Mnt (Mnt-CIP) in which the Mnt was first prepared by acid treatment and vibration ball milling. The surfaces of Mnt were modified by reacting the Mnt suspension in 1.0 M HCl acid and by dispersing the powder with a vibration ball mill, then the CIP drug was added at pH 4 and stirred. The goal was to improve the sustained-release performance of the CIP. This Mnt-CIP drug-release system was characterized by X-ray diffraction, X-ray fluorescence analysis, Fourier-transform infrared spectroscopy, surface area measurement using the Brunauer-Emmett-Teller (BET) method, and ultraviolet spectroscopy. The X-ray diffraction results confirmed the intercalation of CIP into the interlayer space of Mnt. The in vitro release properties of the intercalated CIP were investigated using a simulated phosphate-buffered saline solution (pH 7.4) at 36±0.5°C. The CIP drug exhibited a continued release for 3 h. Moreover, Mnt prepared by HCl acid treatment and dispersion in the vibration ball mill delayed the drug dissolution rate. In summary, the Mnt-CIP composite prepared in this study exhibited slow and sustained release characteristics, indicating that Mnt mined from the Gampo-40 mining area in Gyeongju can be used in various drug-delivery applications.

Keywords

Acid treatmentVibratory ball millCiprofloxacinDrug deliveryMontmorilloniteSustained release
Type
Original Paper
Information
Clays and Clay Minerals , Volume 70 , Issue 1 , February 2022 , pp. 62 - 71
Copyright
Copyright © The Clay Minerals Society 2022

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Footnotes

Myungjae Kim and Ki-Min Roh contributed equally to this work.

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