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A new technique for preparation of porous bioceramics with controllable macrostructures

Published online by Cambridge University Press:  09 July 2018

Chuisheng Zeng ,
Jing Zhang ,
Yanjun Zeng ,
Xiaoming Chen  and
Yuhua Yan
Chuisheng Zeng
Affiliation:
College of Bio-Information, Chongqing University of Post & Telecommunication, Chongqing 400065, China
Jing Zhang
Affiliation:
Neuroscience PET Laboratory, Department of Psychiatry, Mt. Sinai Medical Center, New York 100029, USA
Yanjun Zeng*
Affiliation:
Biomechanics & Medical Information Institute, Beijing University of Technology, Beijing 100022, China
Xiaoming Chen
Affiliation:
Biomedical Materials and Engineering Center, Wuhan University of Technology, Wuhan 430070, China
Yuhua Yan
Affiliation:
Biomedical Materials and Engineering Center, Wuhan University of Technology, Wuhan 430070, China
*
*E-mail: yjzeng@bjpu.edu.cn
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Abstract

The purpose of this study was to develop a simple and economic method for the preparation of porous bioceramics with controllable macrostructure. Raw materials, including very small organic foam balls as the pore-creating reagent, wax (or paraffin) as the solvent, and oleic acid as the surface active agent, were selected along with bioactive materials such as β-TCP ceramic powder as the main component. The selected components were mixed into a slurry at 30–120ºC and shaped into a green body with a hot die-casting machine at 30–90ºC. The green body was then sintered and porous bioceramics were obtained. The main characteristics of porous bioceramics such as weight loss, compressive strength, connection and size of pores, percolation rate of water, apparent porosity and bulk density were measured. The results indicated that the apparent porosity and the specific surface area were large; the pores were connected in three dimensions and the compressive strength was >1.6 MPa. This study demonstrated that the methods used here are simple and effective in generating porous bioceramics with controllable macrostructures.

Keywords

apparent porositybiodegradationbioactive materialsporous bioceramicsceramic biosupportsorganic foam ball
Type
Research Article
Information
Clay Minerals , Volume 44 , Issue 3 , September 2009 , pp. 411 - 416
Copyright
Copyright © The Mineralogical Society of Great Britain and Ireland 2009

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References

Barralet, J.E., Grover, L., Gaunt, T., Wright, A.J. & Gibson, I.R. (2002) Preparation of macroporous calcium phosphate cement tissue engineering scaffold. Biomaterials, 23, 3063–3072.CrossRefGoogle ScholarPubMed
Chandavasu, C., Xanthos, M., Sirkar, K.K. & Gogos, C.G. (2000) Preparation of microporous films from immiscible blends via melt processing. Journal of Plastic Film and Sheeting, 16, 288–300.CrossRefGoogle Scholar
De Groot, K. (1980) Bioceramics consisting of calcium phosphate salts. Biomaterials, 1, 47–50.CrossRefGoogle ScholarPubMed
Ducheyne, P. & Qiu, Q. (1999) Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell ruction. Biomaterials, 20, 2287–2303.CrossRefGoogle Scholar
Gbureck, U., Grolms, O., Barralet, J.E., Grover, L.M. & Thull, R. (2003) Mechanical activation and cement formation of β-tricalcium phosphate. Biomaterials, 24, 4123–4131.CrossRefGoogle ScholarPubMed
Hench, L.L. & Polak, J.M. (2002) Third-generation biomedical materials. Science, 295, 1014–1017.CrossRefGoogle ScholarPubMed
Ishaug, S.L., Crane, G.M., Miller, M.J., Yasko, A.W., Yaszemski, M.J. & Mikos, A.G. (1997) Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds. Journal of Biomedical Materials Research, 36, 17–28.3.0.CO;2-O>CrossRefGoogle ScholarPubMed
John, A., Varma, H.K. & Kumari, T.V. (2003) Surface reactivity of calcium phosphate based ceramics in a cell culture system. Journal of Biomaterials Applications, 18, 63–78.CrossRefGoogle Scholar
LeGeros, R.Z. (1993) Biodegradation and bioresorption of calcium phosphate ceramics. Clinical Materials, 14, 65–88.CrossRefGoogle ScholarPubMed
Lu, J.X., Flautre, B. & Anselme, K. (1997) Study of porous interconnection of bioceramic on cellular rehabilitation in vitro and in vivo. Biomaterials, 10, 583–586.Google Scholar
Ohgushi, H., Okamura, M., Yoshikawa, T., Inoue, K., Senpuku, N., Tamai, S. & Shors, E.C. (1992) Bone formation process in porous calcium carbonate and hydroxyapatite. Journal of Biomedical Materials Research, 26, 885–895.CrossRefGoogle ScholarPubMed
Radin, S.R. & Ducheyne, P. (1993) The effect of calcium phosphate ceramic composition and structure on in vitro behavior. Journal of Biomedical Materials Research, 27, 35–45.CrossRefGoogle ScholarPubMed
Suquet, H., Chevalier, S., Marcilly, C. & Barthomeuf, D. (1991) Preparation of porous materials by chemical activation of the Llano Vermiculite. Clay Minerals, 26, 49–60.CrossRefGoogle Scholar
Takahashi, T., Yamamoto, M., Ioku, K. & Goto, S. (1997) Relationship between compression strength and pore structure of hardened cement pastes. Advances in Cement Research, 9, 25–30.CrossRefGoogle Scholar
Wang, J., de Boer, J. & de Groot, K. (2004) Preparation and characterization of electrodeposited calcium phosphate/chitosan coating on Ti6Al4V plates. Journal of Dental Research, 83, 296–301.CrossRefGoogle ScholarPubMed
Yong-Moo, Lee, Yang, Jo-Seol & Yun-Tak, Lim (2001) Tissue engineered growth of bone by marrow cell transplantation using porous calcium metaphosphate matrices. Journal of Biomedical Materials Research, 54, 216–223.Google Scholar