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Characterization and drug release of benzalkonium chloride-loaded organo-palygorskite or organo-montmorillonite

Published online by Cambridge University Press:  21 July 2023

Héctor A. Lobato-Aguilar ,
Wilberth A. Herrera-Kao ,
Santiago Duarte-Aranda ,
Fernando J. Aguilar-Pérez Open the ORCID record for Fernando J. Aguilar-Pérez [Opens in a new window] ,
Andrés I. Oliva-Arias ,
Víctor Rejón-Moo ,
José M. Baas-López ,
Jorge A. Uribe-Calderón  and
José M. Cervantes-Uc Open the ORCID record for José M. Cervantes-Uc [Opens in a new window]
Héctor A. Lobato-Aguilar
Affiliation:
Centro de Investigación Científica de Yucatán, A.C., Unidad de Materiales, Mérida, México
Wilberth A. Herrera-Kao
Affiliation:
Centro de Investigación Científica de Yucatán, A.C., Unidad de Materiales, Mérida, México
Santiago Duarte-Aranda
Affiliation:
Centro de Investigación Científica de Yucatán, A.C., Unidad de Materiales, Mérida, México
Fernando J. Aguilar-Pérez
Affiliation:
Universidad Autónoma de Yucatán, Facultad de Odontología, Mérida, México
Andrés I. Oliva-Arias
Affiliation:
Centro de Investigación y de Estudios Avanzados (CINVESTAV), Unidad Mérida, Mérida, México
Víctor Rejón-Moo
Affiliation:
Centro de Investigación y de Estudios Avanzados (CINVESTAV), Unidad Mérida, Mérida, México
José M. Baas-López
Affiliation:
Centro de Investigación Científica de Yucatán, A.C., Unidad de Energía Renovable, Mérida, México
Jorge A. Uribe-Calderón
Affiliation:
Centro de Investigación Científica de Yucatán, A.C., Unidad de Materiales, Mérida, México
José M. Cervantes-Uc*
Affiliation:
Centro de Investigación Científica de Yucatán, A.C., Unidad de Materiales, Mérida, México
*
*Corresponding author: José M. Cervantes-Uc; Email: manceruc@cicy.mx
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Abstract

This study examined the incorporation of benzalkonium chloride into palygorskite and montmorillonite, assessing their potential as drug carriers. The aim was to evaluate the use of both clay minerals as viable options for antibacterial drug delivery. Various amounts (0.5, 1.0 and 2.0 times the cation-exchange capacity) of benzalkonium chloride were incorporated into both clay minerals, and the resulting materials were characterized using Fourier-transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction and elemental analysis using both CHNS-O elemental analysis and energy-dispersive X-ray spectroscopy. The Fourier-transform infrared spectroscopy and elemental analysis results indicate that benzalkonium chloride was incorporated successfully into the clay minerals. The X-ray diffraction traces of organo-montmorillonite indicate that the d-value increased as benzalkonium chloride content increased, confirming the intercalation of benzalkonium chloride within the montmorillonite interlayer space. By contrast, this behaviour was not observed for palygorskite. For the benzalkonium chloride-release studies, an initial burst release was found within the first 5 h, followed by a sustained release of benzalkonium chloride during the remaining testing time (24 h). Drug-release profiles were similar for modified palygorskite or montmorillonite during the testing time (24 h). Both clay minerals modified with benzalkonium chloride are promising materials for use as antibacterial fillers for several applications, including in the dental care industry.

Keywords

benzalkonium chloridedrug releasemontmorilloniteorgano-clay mineralspalygorskite
Type
Article
Information
Clay Minerals , Volume 58 , Issue 2 , June 2023 , pp. 102 - 112
Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of The Mineralogical Society of the United Kingdom and Ireland

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Footnotes

Associate Editor: Chun-Hui Zhou

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