Skip to main content Accessibility help

HSP70 and HSP70 mRNA localization in heat-stressed tissues of broilers

  • Sun Pei-Ming (a1) (a2), Liu Yu-Tian (a3), Wang Qing-Hua (a3), Wang Zhi-Liang (a3) and Bao En-Dong (a1)...


The localization of heat shock protein 70 (HSP70) and HSP70 mRNA in the heart, liver, lung, kidney, spleen, thymus and cloacal bursa in broilers that were heat stressed for 6 h was conducted using immunohistochemistry and in situ hybridization techniques. Positive HSP70 mRNA signals were detected in the liver and lung, especially in the vessel walls. A weak presence was found in the myocardial cells. No significant signals were observed in spleen, thymus and cloacal bursa. HSP70 was observed in the vessel walls of all investigated broiler tissues. Localizations of HSP70 and HSP70 mRNA suggest that HSP70 could be correlated with cardiovascular function.


Corresponding author

*Corresponding author. E-mail:


Hide All

First published in Journal of Agricultural Biotechnology 2007, 15(3): 404–408



Hide All
Ao, QL, Xiong, M, Hao, CR and Wang, DX (2002) Changes of nuclear factor-κB and inducible nitric oxide synthase In hypoxic pulmonary hypertension. Chinese Journal of Pathophysiology 18(8): 903906 (in Chinese with English abstract).
Bao, ED, Gong, YY, Hartung, J, et al. (2004) Relation between pathologic damages and HSP70 changes in acute heat stressed broilers. Scientia Agricultura Sinica 37(2): 301305 (in Chinese with English abstract).
Benjamin, IJ and McMilan, DR (1998) Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease. Circulation Research 83: 117132.
Gabai, VL, Meriin, AB, Mosser, DD, et al. (1997) HSP70 prevents activation of stress kinase-A novel pathway of cellular thermotolerance. Biological Chemistry 272(29): 1803318037.
Kiang, JG and Tsokos, GC (1998) Heat shock protein 70 kDa: molecular biology, biochemistry and physiology. Pharmacology and Therapeutics 80(2): 184185.
Knowlton, AA (1995) The role of heat shock proteins in the heart. Molecular Cell Cardiology 27: 121.
Li, YB, Fu, XB, Sun, PM, Wang, ZL and Bao, ED (2005) Effects of heat stressing on broiler immune parameter. Journal of Agricultural Biotechnology 13(3): 394395 (in Chinese with English abstract).
Linquist, S and Craig, EA (1998) The heat shock proteins. Annual Review of Genetics 22: 631.
Morimoto, RI, Tissieres, A and Cesrgopoulos, C (1993) Cell in stress: transcriptional activation of heat shock genes. Science 259: 365.
Sambrook, J and Russell, DW (2001) Molecular Cloning: A Laboratory Manual, 3rd edn. New York: Cold Spring Harbor Laboratory Press.
Tang, YX, Hua, XB, Wang, XQ, Zhou, JW, Liu, HS and Hu, N (1995) Observations on postmortem lesions of dead layers induced by heat stress. Chinese Journal of Veterinary Science 15(4): 381385 (in Chinese with English abstract).
Zhang, SL, Guo, M, Zhang, XS, Zhang, WX, Li, XY and Xu, CS (2000) Study on the expression of HSP70 induced by heat shock in mouse hepatocytes. Chinese Journal of Anatomy 23(4): 329330 (in Chinese with English abstract).
Zhou, JJ, Zhu, YL, Pei, JM, Gao, Z and Zhu, MZ (2002) Progress in research on heat shock proteins in cardiovascular system. Progress in Physiological Sciences 33(4): 299304 (in Chinese with English abstract).


Related content

Powered by UNSILO

HSP70 and HSP70 mRNA localization in heat-stressed tissues of broilers

  • Sun Pei-Ming (a1) (a2), Liu Yu-Tian (a3), Wang Qing-Hua (a3), Wang Zhi-Liang (a3) and Bao En-Dong (a1)...


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.