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Valve-Sparing Replacement of the Aortic Root for a 2-year-old Child with Loeys-Dietz Syndrome

  • Yoshio Ootaki (a1), Minhaz Uddin (a1) and Ross M. Ungerleider (a1)

Abstract

Loeys-Dietz syndrome is a newly recognized constellation that presents with aortic aneurysm or dissection similar to Marfan’s syndrome. We describe successful surgical treatment in a 2-year-old with the syndrome in whom we performed a valve-sparing replacement of the aortic root because of significant dilation of the aortic root and the ascending aorta.

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Corresponding author

Correspondence to: Dr Ross Ungerleider, 11100 Euclid Avenue, Cleveland, OH 44106, USA. Tel: 216-844-3058; Fax: 216-844-3517; E-mail: ross.ungerleider@UHhospitals.org

References

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1.Loeys, BL, Chen, J, Neptune, ER, et al. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat Genet 2005; 37: 275281.
2.David, TE, Feindel, CM. An aortic valve-sparing operation for patients with aortic incompetence and aneurysm of the ascending aorta. J Thorac Cardiovasc Surg 1992; 103: 617621.
3.Williams, JA, Loeys, BL, Nwakanma, LU, et al. Early surgical experience with Loeys-Dietz: a new syndrome of aggressive thoracic aortic aneurysm disease. Ann Thorac Surg 2007; 83: S757S763.
4.Yetman, AT, Beroukhim, RS, Ivy, DD, Manchester, D. Importance of the clinical recognition of Loeys-Dietz syndrome in the neonatal period. Pediatrics 2007; 119: e1199e1202.
5.Lee, RS, Fazel, S, Schwarze, U, et al. Rapid aneurysmal degeneration of a Stanford type B aortic dissection in a patient with Loeys-Dietz syndrome. J Thorac Cardiovasc Surg 2007; 134: 242243.
6.Everitt, MD, Pinto, N, Hawkins, JA, Mitchell, MB, Kouretas, PC, Yetman, AT. Cardiovascular surgery in children with Marfan syndrome or Loeys-Dietz syndrome. J Thorac Cardiovasc Surg 2009; 137: 13271333.
7.Zanotti, G, Vricella, L, Cameron, D. Thoracic aortic aneurysm syndrome in children. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2008; : 1121.
8.Clarke, DR, Campbell, DN, Hayward, AR, Bishop, DA. Degeneration of aortic valve allografts in young recipients. J Thorac Cardiovasc Surg 1993; 105: 934941.
9.Alsoufi, B, Al-Halees, Z, Manlhiot, C, et al. Mechanical valves versus the Ross procedure for aortic valve replacement in children: propensity-adjusted comparison of long-term outcomes. J Thorac Cardiovasc Surg 2009; 137: 362370.
10.Matt, P, Habashi, J, Carrel, T, Cameron, DE, Van Eyk, JE, Dietz, HC. Recent advances in understanding Marfan syndrome: should we now treat surgical patients with losartan? J Thorac Cardiovasc Surg 2008; 135: 389394.

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