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Uncertainty related to evidence

Published online by Cambridge University Press:  14 December 2022

Robert H. Anderson*
Affiliation:
Biosciences Division, Newcastle University, Newcastle-upon-Tyne, UK
*
Author for correspondence: Professor RH Anderson, 60 Earlsfield Road, London SW18 3DN, UK. Tel: 00 44 20 8870 4368. E-mail: sejjran@ucl.ac.uk
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Abstract

Type
Letter to the Editor
Copyright
© The Author(s), 2022. Published by Cambridge University Press

To the Editor,

I enjoyed reading the stimulating lead article in the November issue of the Journal by McMahon and his collaborators. Reference McMahon, Sendžikaitė and Jegatheeswaran1 It is difficult to quibble with their recommendations. On reading a subsequent brief report in the same issue, Reference Kakarla, Sasikumar and Kurup2 however, one was left wondering whether both trainees and their trainers might also need to place emphasis on the credibility of their evidence base, and the value of innate intelligence. My concern in this regard was raised by the suggestion that obvious communications between the ventricular apical components could justifiably be described as “left ventricular-infundibular defects”. Reference Kakarla, Sasikumar and Kurup2 It is now acknowledged that the infundibulum of the right ventricle is a free-standing myocardial sleeve which lifts away the leaflets of the pulmonary valve from the ventricular base. It is the presence of the infundibular sleeve which makes possible the Ross procedure. Reference Merrick, Yacoub, Ho and Anderson3 As such, the infundibulum does not possess a “ventricular apex”, The notion of presence of two apical extensions within the right ventricle is based on a spurious account of ventricular septal development, which has no foundation in scientific evidence. Reference Van Praagh, Geva and Kreutzer4 It is noteworthy that the authors of the brief report offer no substantive evidence to support their inferences. An accurate account is now available describing normal human cardiac development. Reference Hikspoors, Kruepunga, Mommen, Köhler, Anderson and Lamers5 Should we not now expect authors to provide evidence to support their underlying concepts before submitting manuscripts to journals such as Cardiology in the Young? And should we not equally expect their referees to be aware of inaccurate accounts of cardiac development?

Yours faithfully

Robert H. Anderson

Financial support

This research received no specific grant from any funding agency, commercial or not-for-profit sectors.

Conflicts of interest

None.

Footnotes

Please note that, although Professor Anderson is affiliated with Newcastle University, he works from his home address in London.

References

McMahon, C, Sendžikaitė, S, Jegatheeswaran, A, et al. Managing uncertainty in decision-making of common congenital cardiac defects. Cardiol Young 2022; 32: 17051717. DOI 10.1017/S1047951122003316.10.1017/S1047951122003316CrossRefGoogle ScholarPubMed
Kakarla, S, Sasikumar, D, Kurup, H. Left ventricular-infundibular apical septal defect: a rare entity revisited. Cardiol Young 2022; 32: 18541856. DOI 10.1017/S1047951122000695.CrossRefGoogle ScholarPubMed
Merrick, AF, Yacoub, MH, Ho, SY, Anderson, RH. Anatomy of the muscular subpulmonary infundibulum with regard to the Ross procedure. Ann Thorac Surg 2000; 69: 556561.CrossRefGoogle ScholarPubMed
Van Praagh, R, Geva, T, Kreutzer, J. Ventricular septal defects: how shall we describe, name and classify them? J Am Coll Cardiol 1989; 14: 12981299.CrossRefGoogle Scholar
Hikspoors, JP, Kruepunga, N, Mommen, G, Köhler, SE, Anderson, RH, Lamers, WH. A pictorial account of the human embryonic heart between 3.5 and 8 weeks of development. Commun Biol 2022; 5: 122.CrossRefGoogle ScholarPubMed