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Treatment of patients with Eisenmenger's syndrome with Bosentan

Published online by Cambridge University Press:  23 April 2007

Henrik Brun ,
Erik Thaulow ,
Per Morten Fredriksen  and
Henrik Holmstrom
Henrik Brun
Affiliation:
Paediatric Cardiology Unit, Rikshospitalet, Oslo, Norway
Erik Thaulow
Affiliation:
Paediatric Cardiology Unit, Rikshospitalet, Oslo, Norway
Per Morten Fredriksen
Affiliation:
Physiotherapy Department, Rikshospitalet, Oslo, Norway
Henrik Holmstrom
Affiliation:
Paediatric Cardiology Unit, Rikshospitalet, Oslo, Norway
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Abstract

We treated prospectively 14 patients with Eisenmenger's syndrome, with a mean age of 10 years, ranging from 3 to 18 years. Treatment continued for 12 months, and demonstrated a lasting symptomatic improvement, but no improvement in terms of mean saturation of oxygen over 24 hours. Exercise capacity, as judged by peak uptake of oxygen, worsened in the six patients able to perform a treadmill test. The symptomatic benefit from dual blockage of endothelin receptors in these patients may be due to mechanisms other than selective pulmonary vasodilatation alone.

Keywords

Pulmonary hypertensioncongenital heart diseaseexercise testing
Type
Original Article
Information
Cardiology in the Young , Volume 17 , Issue 3 , June 2007 , pp. 288 - 294
Copyright
© 2007 Cambridge University Press

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