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Severe transient neonatal long QT syndrome due to maternal paroxetine usage: a case report

  • Eeke C. M. Leerssen (a1), Ramon O. Tak (a1) and Johannes M. P. J. Breur (a1)

Abstract

A female neonate with in utero selective serotonin reuptake inhibitor exposure presented with bradycardia shortly after birth. Electrocardiography showed severe QT prolongation and second-degree atrioventricular block. Over time QT-times spontaneously normalised and genetic testing did not show mutations associated with long QT syndrome making maternal selective serotonin reuptake inhibitor usage the most likely explanation for the observed severe transient neonatal QT prolongation.

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Corresponding author

Author for correspondence: J. M. P. J. Breur, Department of Paediatric Cardiology, University Medical Centre/Wilhelmina Children’s Hospital, Lundlaan 6, 3584 Utrecht, the Netherlands. Tel: 088 75 555 55; Fax: 088 75 55 23; E-mail: h.breur@umcutrecht.nl

References

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1. Crotti, L, Celano, G, Dagradi, F, Schwartz, P. Congenital long QT syndrome. Orphanet J of Rare Dis 2008 Jul 7; 3: 18.
2. Vincent, GM, Timothy, K, Zhang, L. Congenital long QT syndrome. Card Electrophysiol Rev 2002 Feb; 6: 5760.
3. Camm, AJ, Malik, M, Yap, YG. Acquired Long QT Syndrome, 1st edn. John Wiley & Sons, London, 2008.
4. Marzuillo, P, Benettoni, A, Germani, C, Ferrara, G, D′Agata, B, Barbi, E. Acquired long QT syndrome. Pediatr Emerg Care 2014 Apr; 30: 257261.
5. Dubnov-Raz, G, Juurlink, D, Fogelman, R, et al. Antenatal use of selective serotonin-reuptake inhibitors and QT interval prolongation in newborns. Pediatrics 2008 Sep; 122: e710e715.

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Severe transient neonatal long QT syndrome due to maternal paroxetine usage: a case report

  • Eeke C. M. Leerssen (a1), Ramon O. Tak (a1) and Johannes M. P. J. Breur (a1)

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