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Neonatal death due to transposition in association with premature closure of the oval foramen

  • Michael Ashworth (a1), Mudher Al Adnani (a1) and Neil J. Sebire (a1)

Abstract

We present a male infant, born at term, who collapsed and died at 30 minutes of age. Autopsy demonstrated concordant atrioventricular and discordant ventriculo-arterial connections with premature closure of the oval foramen, which bulged markedly into the left atrium. Premature closure of the oval foramen is rare in the setting of transposition. As far as we know, there have been only three previously reported cases.

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Corresponding author

Correspondence to: Michael Ashworth, Department of Paediatric Histopathology, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, United Kingdom. Tel: +0207 829 8663; Fax: +0207 829 7875; E-mail: AshwoM@gosh.nhs.uk

References

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References

Bhatt DR, Jue KL. Prenatal closure of the foramen ovale in complete transposition of great vessels. Observations in a case with intact ventricular septum and normally developed left heart chambers. Am J Cardiol 1979; 44: 563565.
Berry LM, Padbury J, Novoa-Takara L. et al. Premature “closing” of the foramen ovale in transposition of the great arteries with intact ventricular septum: rare cause of sudden neonatal death. Pediatr Cardiol 1998; 19: 246248.
Donofrio MT. Premature closure of the foramen ovale and ductus arteriosus in a fetus with transposition of the great arteries. Circulation 2002; 105: e65.
Lambert EC, Mneon VA, Wagner HR, et al. Sudden unexpected death from cardiovascular disease in children. A cooperative international study. Am J Cardiol 1974; 34: 8996.

Keywords

Neonatal death due to transposition in association with premature closure of the oval foramen

  • Michael Ashworth (a1), Mudher Al Adnani (a1) and Neil J. Sebire (a1)

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