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Left and right ventricular function by echocardiography, tissue doppler imaging, carotid intima media thickness, and asymmetric dimethylarginine levels in female adolescents with vitamin D deficiency

Published online by Cambridge University Press:  25 May 2023

Eyup Aslan Open the ORCID record for Eyup Aslan [Opens in a new window] ,
Ahmet Sert Open the ORCID record for Ahmet Sert [Opens in a new window] ,
Muammer Buyukinan ,
Mustafa Ozgur Pirgon ,
Huseyin Kurku ,
Hakan Yılmaz  and
Dursun Odabas
Eyup Aslan*
Affiliation:
Department of Pediatric Cardiology, Denizli State Hospital, Denizli, Turkey
Ahmet Sert
Affiliation:
Department of Pediatric Cardiology, Faculty of Medicine, Selcuk University, Konya, Turkey
Muammer Buyukinan
Affiliation:
Department of Pediatric Endocrinology and Diabetes, University of Health Sciences, Konya City Hospital, Konya, Turkey
Mustafa Ozgur Pirgon
Affiliation:
Department of Pediatric Endocrinology and Diabetes, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
Huseyin Kurku
Affiliation:
Department of Biochemistry, University of Health Sciences, Konya City Hospital, Konya, Turkey
Hakan Yılmaz
Affiliation:
Department of Radiology, University of Health Sciences, Konya Training and Research Hospital, Konya, Turkey
Dursun Odabas
Affiliation:
Department of Pediatric Cardiology, Faculty of Medicine, Karamanoglu Mehmetbey University, Karaman, Turkey
*
Corresponding author: E. Aslan; Email: eyupaslan6@gmail.com
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Abstract

Background:

The aim of our study was to assess left and right ventricle systolic and diastolic functions in female adolescents with vitamin D deficiency using conventional echocardiography and pulsed-wave tissue Doppler imaging and to investigate carotid intima media thickness and asymmetric dimethylarginine levels.

Methods:

Sixty-six female adolescents were enrolled in this study. The female adolescents were divided into a vitamin D deficiency group (n: 34) and a control group (n: 32). All subjects underwent laboratory blood tests, including asymmetric dimethyl arginine, complete two-dimensional, pulse, and tissue Doppler echocardiography, and measurement of the carotid intima-media thickness.

Results:

The vitamin D-deficient female adolescent group had normal left and right ventricle systolic and diastolic functions and normal global systolic and diastolic myocardial performance. In the patients with vitamin D deficiency, the carotid intima-media thickness was higher than that in the controls. In the patients within the vitamin D deficiency group, vitamin D was found to be positively correlated with magnesium and negatively correlated with phosphorus and left atrial dimension.

Conclusions:

The results of this study demonstrate that vitamin D deficiency in female adolescence is associated with normal myocardial geometry and function. Although it has been associated with normal levels of asymmetric dimethyl arginine concentration, high measured carotid intima-media thickness may reflect endothelial dysfunction.

Keywords

Adolescentasymmetric dimethyl argininecardiovascular diseasecarotid intima media thicknessvitamin D deficiency
Type
Original Article
Information
Cardiology in the Young , Volume 34 , Issue 1 , January 2024 , pp. 105 - 112
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Copyright
© The Author(s), 2023. Published by Cambridge University Press

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