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Distribution of ABO phenotypes in patients with congenital cardiac defects

Published online by Cambridge University Press:  01 June 2008

Kirsten C. Odegard ,
Peter C. Laussen ,
David Zurakowski ,
Stephan J. Hornykewycz ,
Jonathan C. Laussen  and
Dolly D. Hansen
Kirsten C. Odegard*
Affiliation:
Department of Anesthesiology, Perioperative and Pain Medicine Children’s Hospital, Boston, and Harvard Medical School, Boston, Massachusetts, United States of America
Peter C. Laussen
Affiliation:
Department of Anesthesiology, Perioperative and Pain Medicine Children’s Hospital, Boston, and Harvard Medical School, Boston, Massachusetts, United States of America
David Zurakowski
Affiliation:
Department of Anesthesiology, Perioperative and Pain Medicine Children’s Hospital, Boston, and Harvard Medical School, Boston, Massachusetts, United States of America
Stephan J. Hornykewycz
Affiliation:
Department of Anesthesiology, Perioperative and Pain Medicine Children’s Hospital, Boston, and Harvard Medical School, Boston, Massachusetts, United States of America
Jonathan C. Laussen
Affiliation:
Department of Anesthesiology, Perioperative and Pain Medicine Children’s Hospital, Boston, and Harvard Medical School, Boston, Massachusetts, United States of America
Dolly D. Hansen
Affiliation:
Department of Anesthesiology, Perioperative and Pain Medicine Children’s Hospital, Boston, and Harvard Medical School, Boston, Massachusetts, United States of America
*
Correspondence to: Kirsten C. Odegard, MD, Cardiac Anesthesia Service, 300 Longwood Avenue, Children’s Hospital Boston, Boston, MA 02115, USA. Tel: 617 355 6225; Fax: 617 278 9237; E-mail: Kirsten.odegard@childrens.harvard.edu
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Abstract

Background

Cardiac anomalies are among the most frequent congenital malformations, but the basic underlying causes for most cardiac defects remains undetermined. Some 40 years ago, a higher incidence of blood group B was reported in a small number of African-American children with congenital cardiac defects. In this study, we sought to re-evaluate this association using a larger population.

Methods and Results

We collected data from 1985 patients undergoing cardiac surgery from July, 2000, through December, 2004. We divided the patients into 6 subgroups according to their diagnosis. We then compared the prevalence of ABO phenotypes between the patients and the general population of the United States of America by chi-square analysis. There were no significant differences in the distribution of the ABO phenotypes amongst the subgroups of those with congenital cardiac disease, or any for subgroup compared to the general population.

Conclusion

While statistical significance is influenced by the size of the population within the United States of America and the small numbers within each of our subgroups of patients with congenital cardiac disease, we have been unable to show any relationship between the distribution of ABO phenotypes and the existence of congenital cardiac disease.

Keywords

Paediatric cardiac diseaseblood groupsanaesthesis
Type
Original Article
Information
Cardiology in the Young , Volume 18 , Issue 3 , June 2008 , pp. 307 - 310
Copyright
Copyright © Cambridge University Press 2008

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