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Cyclosporin for treatment of refractory multisystemic inflammatory syndrome in a child

Published online by Cambridge University Press:  02 September 2022

Luisa Berenise Gámez-González Open the ORCID record for Luisa Berenise Gámez-González [Opens in a new window] ,
Hiromichi Hamada Open the ORCID record for Hiromichi Hamada [Opens in a new window]  and
Marco Antonio Yamazaki-Nakashimada
Luisa Berenise Gámez-González*
Affiliation:
Allergy and Immunology Department, Hospital Infantil de Especialidades de Chihuahua, Chihuahua, Mexico
Hiromichi Hamada
Affiliation:
Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan
Marco Antonio Yamazaki-Nakashimada
Affiliation:
Clinical Immunology Department, Instituto Nacional de Pediatría, Mexico City, Mexico
*
Author for correspondence: Luisa Berenise Gamez-Gonzalez, MD, Allergy and Clinical Immunology Department, Hospital Infantil de Especialidades de Chihuahua, Chihuahua, Mexico. E-mail: dra.luisa.gamez@gmail.com
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Abstract

Multisystemic inflammatory syndrome in children is an inflammatory condition with multiorgan dysfunction that manifest late in the course of Severe acute respiratory syndrome coronavirus 2 infection. We present a 12-year-old boy with a history of fever, vomiting, diarrhoea, and abdominal pain. He developed shock with ventricular dysfunction and pericardial effusion. He was diagnosed with multisystemic inflammatory syndrome in children and treatment with intravenous immunoglobulins, corticosteroids, and tocilizumab proved to be ineffective. Eventually, the patient responded to cyclosporin-A treatment. Multisystemic inflammatory syndrome in children has been treated with immunoglobulins and glucocorticoids and in refractory cases biologics and cyclosporin-A have been used. Intravenous and oral cyclosporin-A seems to be a safe and effective alternative treatment for refractory multisystemic inflammatory syndrome in children patients.

Keywords

Kawasaki diseasecyclosporineMIS-CSARS-CoV2COVID-19
Type
Brief Report
Information
Cardiology in the Young , Volume 33 , Issue 5 , May 2023 , pp. 800 - 802
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Copyright
© The Author(s), 2022. Published by Cambridge University Press

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References

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