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Association of MnSOD gene polymorphism with susceptibility to Kawasaki disease in Chinese children

Published online by Cambridge University Press:  30 October 2020

Jiping Wu Open the ORCID record for Jiping Wu [Opens in a new window] ,
Meng Yu ,
Lihua Huang ,
Yujie Qian ,
Min Kong ,
Zhijuan Kang  and
Zuocheng Yang
Jiping Wu
Affiliation:
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Meng Yu
Affiliation:
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Lihua Huang
Affiliation:
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Yujie Qian
Affiliation:
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Min Kong
Affiliation:
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Zhijuan Kang
Affiliation:
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Zuocheng Yang*
Affiliation:
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
*
Author for correspondence: Z. Yang, MD, Department of Pediatrics, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha, Hunan 410013, China. E-mail: yang_zcr@126.com
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Abstract

Background:

Kawasaki disease is a type of acute febrile rash disease that is common in children and is characterised by primary lesions of systemic middle and small vasculitis, which can lead to coronary artery lesions. Manganese superoxide dismutase (MnSOD), one of the most important antioxidases in the human body, plays a key role in maintaining the balance of free radicals in the human body. Two single-nucleotide polymorphisms (SNPS) (rs4880 and rs5746136) in the MnSOD gene were related to oxidative stress disease. The purpose of this study is to explore the possible relationship between MnSOD gene polymorphisms and Kawasaki disease susceptibility.

Methods:

This study included 100 Kawasaki disease children and 102 healthy children. Two single-nucleotide polymorphisms (rs4880 and rs5746136) were detected by polymerase chain reaction sequence-based typing.

Results:

There was a significant difference in both the genotype frequency (χ2 = 10.805, p = 0.005) and the allele frequency (χ2 = 7.948, p = 0.005) of rs5746136 between the Kawasaki disease group and the control group. Children with the A allele had a 0.558 times lower risk of Kawasaki disease than those without the A allele (χ2 = 7.948, p = 0.005, odds ratio = 0.558, 95% confidence interval = 0.371–0.838). There was no significant difference in the genotype and gene frequencies of rs5746136 between the Kawasaki disease-coronary artery lesion and Kawasaki disease-without coronary artery lesion groups (p > 0.05), and there was no significant difference in the rs4880 genotype and allele frequencies between the Kawasaki disease and healthy control groups or between the Kawasaki disease-coronary artery lesion and Kawasaki disease-without coronary artery lesions groups (p > 0.05).

Conclusion:

This study provides evidence supporting an association between MnSOD gene polymorphisms and susceptibility to Kawasaki disease. The genotype AA and the allele A of the MnSOD gene locus rs5746136 were risk factors for Kawasaki disease.

Keywords

Kawasaki diseaseMnSOD genegene polymorphismchildren
Type
Original Article
Information
Cardiology in the Young , Volume 31 , Issue 2 , February 2021 , pp. 179 - 185
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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