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Association between polymorphisms in IL27 and risk for CHD in a Chinese population

  • Danyan Zhang (a1) (a2) (a3), Mingfu Ma (a1) (a2) (a3), Yuyou Yang (a1) (a2) (a3), Ling Wan (a1) (a2) (a3), Zhixi Yang (a1) (a2) (a3), Jing Lv (a1) (a2) (a3), Xinsheng Li (a1) (a2) (a3), Hao Yang (a1) (a2) (a3), Pei Huang (a4) and Lianbing Li (a1) (a2) (a3)...

Abstract

Background

IL-27, a member of the IL-12 family, has been involved in maternal tolerance to the foetus and successful pregnancy. Growing evidences indicate that IL-27 plays a crucial role in pregnancy.

Aim

We carried out the present study in order to investigate whether polymorphisms in the IL27 are associated with the risk for CHDs, including atrial septal defect and ventricular septal defect.

Patients and methods

We conducted this case–control study among 247 atrial septal defect patients, 150 ventricular septal defect patients, and 368 healthy controls in a Chinese population using polymerase chain reaction-restriction fragment length polymorphism assay.

Results

Significantly increased risk for atrial septal defect (p=0.001, OR=1.490, 95% CI=1.178–1.887) and ventricular septal defect (p=0.004, OR=1.502, 95% CI=1.139–1.976) was observed to be associated with the allele G of rs153109. In a dominant model, we have also observed that increased susceptibilities for atrial septal defect (p<0.01, OR=1.89, 95% CI=1.35–2.63) and ventricular septal defect (p<0.01, OR=2.50, 95% CI=1.67–3.85) were statistically associated with rs153109; however, no association was found between CHD risk and rs17855750 in the IL27 gene.

Conclusion

The 153109 of the IL27 gene may be associated with the susceptibility to CHD, including atrial septal defect and ventricular septal defect.

Copyright

Corresponding author

Correspondence to: L. Li, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing 400020, P.R. China. Tel: + 86 236 786 7492; Fax: +86 238 671 5000; E-mail: lilianbing677@163.com

References

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