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Adenosine reverses life-threatening persistent pulmonary hypertension of the neonate refractory to triple vasodilator therapy

Published online by Cambridge University Press:  13 October 2021

Lucie Genet
Affiliation:
Division of Pediatrics and Neonatal Critical Care, “A.Béclère” Medical Center, Paris Saclay University Hospitals, APHP, Paris, France
Daniele De Luca*
Affiliation:
Division of Pediatrics and Neonatal Critical Care, “A.Béclère” Medical Center, Paris Saclay University Hospitals, APHP, Paris, France Physiopathology and Therapeutic Innovation Unit-INSERM U999, Paris Saclay University, Paris, France
*
Author for correspondence: D. De Luca, Service de Pédiatrie et Réanimation Néonatale, Hôpital “A. Béclère” - GHU Paris Saclay, APHP, 157 rue de la Porte de Trivaux, 92140 Clamart, Paris-IDF, France. Tel: +33 (0)145374837; Fax: +33 (0)145374546. E-mail: dm.deluca@icloud.com

Abstract

Persistent pulmonary hypertension of the neonate can cause acute and life-threatening hypoxia, but preterm neonates are not suitable candidate to extra-corporeal life support. We report the unique case of an extremely preterm neonates with life-threatening persistent pulmonary hypertension refractory to triple vasodilator therapy (nitric oxide, iloprost, and bosentan), which has been successfully treated with the addition of adenosine continuous infusion.

Type
Brief Report
Copyright
© The Author(s), 2021. Published by Cambridge University Press

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