Hostname: page-component-77c89778f8-n9wrp Total loading time: 0 Render date: 2024-07-19T13:06:48.989Z Has data issue: false hasContentIssue false

The use of tranexamic acid for trauma patients?

Published online by Cambridge University Press:  11 May 2015

Bryan J. Weber*
Affiliation:
Department of Emergency Medicine, University of Alberta, Edmonton, AB
Colleen B. Kjelland
Affiliation:
Department of Emergency Medicine, University of Alberta, Edmonton, AB
*
Walter C. MacKenzie Health Sciences Centre, 1G1.59, 8440-112 Street, Edmonton, AB T6G 2B7; bryanjweber@ualberta.ca

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Knowledge to Practice • Des connaissances à la pratique
Copyright
Copyright © Canadian Association of Emergency Physicians 2012

References

REFERENCES

1.Krug, EG, Sharma, GK, Lozano, R. The global burden of injuries. Am J Public Health 2000;90:523–6, doi:10.2105/AJPH.90.4.523.Google ScholarPubMed
2.Sauaia, A, Moore, F, Moore, E, et al. Epidemiology of trauma deaths: a reassessment. J Trauma 1995;38:185–93, doi:10.1097/00005373-199502000-00006.CrossRefGoogle ScholarPubMed
3.Heckbert, S, Vedder, N, Hoffman, W, et al. Outcome after hemorrhagic shock in trauma patients. J Trauma 1998;45:545–9, doi:10.1097/00005373-199809000-00022.CrossRefGoogle ScholarPubMed
4.Hoylaerts, M, Lijnen, H, Collen, D. Studies on the mechanism of the antifibrinolytic action of tranexamic acid. Biochim Biophys Acta 1981;673:7585, doi:10.1016/0304-4165(81)90312-3.CrossRefGoogle ScholarPubMed
5.Henry, DA, Carless, PA, Moxey, AJ, et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2007;(4):D001886.CrossRefGoogle ScholarPubMed
6.Horrow, J, Hlavacek, J, Strong, M, et al. Prophylactic tranexamic acid decreases bleeding after cardiac operations. J Thorac Cardiovasc Surg 1990;99:70–4.CrossRefGoogle ScholarPubMed
7.Horrow, JC, Riper, DFV, Strong, MD, et al. Hemostatic effects of tranexamic acid and desmopressin during cardiac surgery. Circulation 1991;84:2063–70.CrossRefGoogle ScholarPubMed
8.Boylan, JF, Klinck, JR, Sandler, AN, et al. Tranexamic acid reduces blood loss, transfusion requirements, and coagulation factor use in primary orthotopic liver transplantation. Anesthesiology 1996;85:1043–8; discussion 30A-31A.CrossRefGoogle ScholarPubMed
9.Benoni, G, Fredin, H. Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients. J Bone Joint Surg Br 1996;78:434–40.CrossRefGoogle ScholarPubMed
10.Hiippala, ST, Strid, LJ, Wennerstrand, MI, et al. Tranexamic acid radically decreases blood loss and transfusions associated with total knee arthroplasty. Anesth Analg 1997;84:839–44.CrossRefGoogle ScholarPubMed
11.Ekbäck, G, Axelsson, K, Ryttberg, L, et al. Tranexamic acid reduces blood loss in total hip replacement surgery. Anesth Analg 2000;91:1124–30, doi:10.1213/00000539-200011000-00014.CrossRefGoogle ScholarPubMed
12.Zufferey, PJ, Miquet, M, Quenet, S, et al. Tranexamic acid in hip fracture surgery: a randomized controlled trial. Br J Anaesth 2010;104:2330, doi:10.1093/bja/aep314.CrossRefGoogle ScholarPubMed
13.Lawson, J, Murphy, M. Challenges for providing effective hemostasis in surgery and trauma. Semin Hematol 2004;41(1 Suppl 1):5564.CrossRefGoogle ScholarPubMed
14.Coats, T, Roberts, I, Shakur, H. Antifibrinolytic drugs for acute traumatic injury. Cochrane Database Syst Rev 2004;(4):D004896.CrossRefGoogle ScholarPubMed
15.Spahn, DR, Cerny, V, Coats, TJ, et al. Task Force for Advanced Bleeding Care in Trauma. Management of bleeding following major trauma: a European guideline. Crit Care 2007;11:R17, doi:10.1186/cc5686.CrossRefGoogle ScholarPubMed
16.Martin, K, Wiesner, G, Breuer, T, et al. The risks of aprotinin and tranexamic acid in cardiac surgery: a one-year follow-up of 1188 consecutive patients. Anesth Analg 2008;107:1783–90.CrossRefGoogle ScholarPubMed
17.Murkin, JM, Falter, F, Granton, J, et al. High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients. Anesth Analg 2010;110:350–3, doi:10.1213/ANE.0b013e3181c92b23.CrossRefGoogle ScholarPubMed
18.Levy, JH. Antifibrinolytic therapy: new data and new concepts. Lancet 2010;376:3–4, doi:10.1016/S0140-6736(10)60939-7.CrossRefGoogle ScholarPubMed
19.Furtmüller, R, Schlag, M, Berger, M, et al. Tranexamic acid, a widely used antifibrinolytic agent, causes convulsions by a gamma-aminobutyric acid(A) receptor antagonistic effect. J Pharmacol Exp Ther 2002;301:168–73, doi:10.1124/jpet.301.1.168.CrossRefGoogle ScholarPubMed