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Successful treatment of pediatric stroke with recombinant tissue plasminogen activator (rt-PA): a case report and review of the literature

Published online by Cambridge University Press:  21 May 2015

Shirra Cremer
Affiliation:
Department of Biostatistics and Epidemiology, University of Western Ontario, London, Ont.
Yaniv Berliner
Affiliation:
Division of Emergency Medicine, University of Western Ontario, London, Ont.
David Warren
Affiliation:
Department of Paediatrics, University of Western Ontario, London, Ont.
Andrew E. Jones*
Affiliation:
Division of Emergency Medicine, University of Western Ontario, London, Ont.
*
Emergency Department, Rm. E1-124, London Health Sciences Centre, Victoria Campus, 800 Commissioners Rd. E., London ON N6A 5W9; jonesmd@gmail.com

Abstract

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Pediatric stroke is a rare disorder with a paucity of evidence-based treatment options, and can result in significant morbidity and mortality. In contrast to adult acute ischemic stroke, where the use of recombinant tissue plasminogen activator (rt-PA) has been studied in several large, randomized clinical trials, no high-level evidence exists for the use of thrombolytics in children with stroke. We report a case of a 15-year-old girl who suffered an acute ischemic stroke and had a dramatic improvement in symptoms following the administration of intravenous rt-PA.

Type
Case Report • Rapport de cas
Copyright
Copyright © Canadian Association of Emergency Physicians 2008

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