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Steroids for patients in septic shock: the results of the CORTICUS trial

Published online by Cambridge University Press:  11 May 2015

Alina Toma
Affiliation:
Department of Medicine, Division of Critical Care Medicine, and Department of Emergency Medicine, University of Toronto, Toronto, ON
Angela Stone
Affiliation:
Department of Medicine, Division of Critical Care Medicine, and Department of Emergency Medicine, University of Toronto, Toronto, ON
Robert S. Green
Affiliation:
Department of Medicine, Division of Critical Care Medicine, and Department of Emergency Medicine, Queen Elizabeth II Health Sciences Centre, and Departments of Medicine and Emergency Medicine, Dalhousie University, Halifax, NS
Sara Gray*
Affiliation:
Department of Medicine, Division of Critical Care Medicine, and Department of Emergency Medicine, St. Michael's Hospital, and Department of Medicine, University of Toronto, Toronto, ON
*
St. Michael's Hospital, 30 Bond Street, Room 4-036 Queen Wing, Toronto, ON M5B 1W8; grays@smh.ca

Abstract

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Type
Knowledge to Practice • Des connaissances à la pratique
Copyright
Copyright © Canadian Association of Emergency Physicians 2011

References

REFERENCES

1.Martin, GS, Mannino, DM, Eaton, S, et al. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003;348:1546–54, doi:10.1056/NEJMoa022139.CrossRefGoogle ScholarPubMed
2.Dombrovskiy, VY, Martin, AA, Sunderram, J, et al. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med 2007;35:1244–50, doi:10.1097/01.CCM.0000261890.41311.E9.CrossRefGoogle ScholarPubMed
3.Esper, A, Martin, GS. Is severe sepsis increasing in incidence AND severity? Crit Care Med 2007;35:1414, doi:10.1097/01.CCM.0000262946.68003.21.Google Scholar
4.Padkin, A, Goldfrad, C, Brady, AR, et al. Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland. Crit Care Med 2003;31:2332–8, doi:10.1097/01.CCM.0000085141.75513.2B.CrossRefGoogle ScholarPubMed
5.Vincent, JL, Sakr, Y, Sprung, CL, et al. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 2006;34:344–53, doi:10.1097/01.CCM.0000194725.48928.3A.Google Scholar
6.Dombrovskiy, VY, Martin, AA, Sunderram, J, et al. Facing the challenge: decreasing case fatality rates in severe sepsis despite increasing hospitalizations. Crit Care Med 2005;33:2555–62, doi:10.1097/01.CCM.0000186748.64438.7B.CrossRefGoogle ScholarPubMed
7.Marx, JA, Hockberger, RS, Walls, RM. Rosen’s emergency medicine, concepts and clinical practice, 7th ed. Philadelphia: Mosby Elsevier, 2010.Google Scholar
8.Annane, D, Maxime, V, Ibrahim, F, et al. Diagnosis of adrenal insufficiency in severe sepsis and septic shock. Am J Respir Crit Care Med 2006;174:1319–26, doi:10.1164/rccm.200509-1369OC.Google Scholar
9.Sprung, CL, Annane, D, Keh, D, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008;358:111–24, doi:10.1056/NEJMoa071366.Google Scholar
10.Dellinger, RP, Caler, JM, Masur, H, et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004;32:858–73, doi:10.1097/01.CCM.0000117317.18092.E4.CrossRefGoogle ScholarPubMed
11.Dellinger, RP, Carlet, JM, Masur, H, et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive CareMed 2004;30:536–55, doi:10.1007/s00134-004-2398-y.CrossRefGoogle ScholarPubMed
12.Rivers, E, Nguyen, B, Havstad, S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368, doi:10.1056/NEJMoa010307.Google Scholar
13.Green, RS, Djogovic, D, Gray, S, et al. Canadian Association of Emergency Physicians Sepsis guidelines: the optimal management of severe sepsis in Canadian emergency departments. CJEM 2008;10:443–59.Google Scholar
14.Dellinger, RP, Levy, MM, Carlet, JM, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 2008;34:1760, doi:10.1007/s00134-007-0934-2.Google Scholar
15.Marik, PE, Pastores, SM, Annane, D, et al. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 2008;36:1937–49, doi:10.1097/CCM.0b013e31817603ba.CrossRefGoogle ScholarPubMed
16.Annane, D, Bellissant, E, Bollaert, PE. Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review. JAMA 2009;301:2362–75, doi:10.1001/jama.2009.815.Google Scholar
17.Annane, D, Sebille, V, Charpentier, C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002;288:862–71, doi:10.1001/jama.288.7.862.Google Scholar
18.Mueller, PS, Montori, VM, Bassler, D, et al. Ethical issue in stopping randomized trials early because of apparent benefit. Ann Intern Med 2007;146:878–81.CrossRefGoogle ScholarPubMed
19.Bassler, D, Briel, M, Montori, VM, et al. Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. JAMA 2010;303:1180–7, doi:10.1001/jama.2010.310.Google Scholar
20.Montori, VM, Devereaux, PJ, Adhikari, NKJ, et al. Randomized trials stopped early for benefit: a systematic review. JAMA 2005;294:2203–9, doi:10.1001/jama.294.17.2203.Google Scholar