Hostname: page-component-8448b6f56d-tj2md Total loading time: 0 Render date: 2024-04-23T08:23:21.772Z Has data issue: false hasContentIssue false
  • English
  • Français

Delayed salicylate toxicity following enteric-coated acetylsalicylic acid overdose: a case report and review of the literature

Published online by Cambridge University Press:  21 May 2015

Robert Drummond ,
Nadine Kadri  and
Julie St-Cyr
Robert Drummond*
Affiliation:
Department of Emergency Medicine, St. Mary’s Hospital, Montreal, Que.
Nadine Kadri
Affiliation:
Medical Biochemistry, McGill University, Montreal
Julie St-Cyr
Affiliation:
Department of Medical Biochemistry, St. Mary’s Hospital, Montreal
*
St. Mary’s Hospital, 3830 Lacombe Ave., Montreal QC H3T 1M5

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Salicylates are widely available and potentially lethal. Clinical and laboratory findings associated with enteric-coated acetylsalicylic acid (ECASA) ingestion may be delayed more than 24 hours. When dealing with patients who have a history of significant ingestion, emergency physicians should consider initiating therapy regardless of initial salicylate levels. Prolonged observation may be necessary in cases of suspected ECASA overdose.

Keywords

acetylsalicylic acidsalicylateintoxicationoverdose
Type
Case Report • Observations
Information
Canadian Journal of Emergency Medicine , Volume 3 , Issue 1 , January 2001 , pp. 44 - 46
Copyright
Copyright © Canadian Association of Emergency Physicians 2001

References

1.Done, AK.Salicylate intoxication: significance of measurements of salicylate in blood in cases of acute ingestion. Pediatrics 1960;26:800–7.CrossRefGoogle ScholarPubMed
2.Todd, PJ, Sills, JA, Harris, F.Problems with overdoses of sustained release aspirin. Lancet 1981;1:777.CrossRefGoogle ScholarPubMed
3.Kwong, TC, Laczin, J, Baum, J.Self-poisoning with enteric-coated aspirin. Am L Clin Path 1983;80:888–90.CrossRefGoogle ScholarPubMed
4.Wortzman, DJ, Grunfeld, A.Delayed absorption following enteric-coated aspiring overdose. Ann Emerg Med 1987;16:434–6.CrossRefGoogle Scholar
5.Pierce, RP, Gazewood, J, Blake, RL.Salicylate poisoning from enteric-coated aspirin. Postgrad Med 1991;89:61–4.CrossRefGoogle ScholarPubMed
6.Gaudreault, P, Temple, AR, Lovejoy, FH.The relative severity of acute versus chronic salicylate poisoning in children: a clinical comparison. Pediatrics 1982;70:566–9.CrossRefGoogle ScholarPubMed
7.Needs, CJ, Brooks, PM.Clinical pharmacokinetics of the salicylates. Clin Pharmacokinet 1985;10:164–77.CrossRefGoogle ScholarPubMed
8.Levy, G.Clinical pharmacokinetics of salicylates: a reassessment. Br J Clin Pharmacol 1980;10:285S–290S.CrossRefGoogle ScholarPubMed
9.Dugandzic, RM, Tierney, MG, Dickinson, GE, Dolan, MC, McKnight, DR.Evaluation of the validity of the Done nomogram in the management of acute salicylate intoxication. Ann Emerg Med 1989;18:1186–90.CrossRefGoogle ScholarPubMed
10.Poisoning with enteric-coated aspirin [editorial]. Lancet 1981; 2:130.Google Scholar
11.Baum, J.Enteric-coated aspirin and the problem of gastric retention. J Rheumatol 1984;11:250.Google ScholarPubMed
12.Bogacz, K, Caldron, P.Enteric-coated aspirin bezoar: elevation of serum salicylate by barium study. Am J Med 1987;83:783–6.CrossRefGoogle ScholarPubMed
13.Taylor, JR, Streetman, DS, Castle, SS.Medication bezoars: a literature review and report of a case. Ann Pharmacother 1998; 32:940–6.CrossRefGoogle ScholarPubMed