Skip to main content Accessibility help
×
Home

Dantrolene for the treatment of MDMA toxicity

  • Brian E. Grunau (a1), Matthew O. Wiens (a2) and Marc Greidanus (a3)

Abstract

MDMA (3,4-methylenedioxymethamphetamine), popularly known as “Ecstasy,” was first introduced and patented by Merck & Co., Inc., in 1914 as an appetite suppressant. Currently, its primary role is as an illegal stimulant used to produce a euphoric effect during parties. This case report describes a 31-year-old man who, after taking 3 tablets of Ecstasy, presented to an emergency department with a decreased level of consciousness and became progressively hyperthermic and rigid. During the course of his acute illness, his temperature reached 42.2°C rectally. He was given mechanical ventilation. He was aggressively cooled and dantrolene was initiated. Soon after the administration of dantrolene his temperature decreased and his rigidity began to resolve. The only complication was rhabdomyolysis with a creatine kinase level increasing to over 150 μkat/L. This did not progress to acute renal failure. The patient made a full recovery and was discharged to psychiatry for assessment.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Dantrolene for the treatment of MDMA toxicity
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Dantrolene for the treatment of MDMA toxicity
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Dantrolene for the treatment of MDMA toxicity
      Available formats
      ×

Copyright

Corresponding author

45600 Menholm Rd., Department of Pharmacy, Chilliwack General Hospital, Chilliwack BC V2P 1P7; matthew.wiens@fraserhealth.ca

References

Hide All
1.Merck, E, inventor. Varfeharen Zur Darstellung Von Alkyloxyaryl-Dialyoxyaryl-Und Alkylenedioxyarylaminopropanen Bzw. Deren Am Stickstoff Monoalkylierten. German patent 274350. 1914.
2.Adlaf, EM, Begin, P, Sawka, E. Canadian Addiction Survey (CAS): a national survey of Canadians’ use of alcohol and other drugs: prevalence of use and related harms, detailed report. Ottawa (ON): Canadian Centre on Substance Abuse (CCSA); 2005.
3.Eaton, DK, Kann, L, Kinchen, S, et al. Youth risk behavior surveillance — United States, 2007. MMWR Surveill Summ 2008;57:1131.
4.Gore, SM. Fatal uncertainty: death-rate from use of ecstasy or heroin. Lancet 1999;354:1265–6.
5.Hall, AP, Henry, JA Acute toxic effects of “ecstacy” (MDMA) and related compounds: overview of pathophysiology and clinical management. Br J Anaesth 2006;96:678–85.
6.Boyer, EW, Shannon, M. The serotonin syndrome. N Engl J Med 2005;352:1112–20.
7.Kalant, H. The pharmacology and toxicology of “ecstasy” (MDMA) and related drugs. CMAJ 2001;165:917–28.
8.Larner, AJ. Dantrolene and “ecstasy” overdose. Anaesthesia 1993;48:179–80.
9.Singarajah, C, Lavies, NG. An overdose of ecstasy. A role for dantrolene. Anaesthesia 1992;47:686–7.
10.Duffy, MR, Ferguson, C. Role of dantrolene in treatment of heat stroke associated with ecstasy ingestion. Br J Anaesth 2007;98:148–9.
11.Grunau, BE, Wiens, MO, Brubacher, JR. Dantrolene in the treatment of MDMA-related hyperpyrexia: a systematic review. CJEM 2010;12:435–42.

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed