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Comparison of ketorolac dosing in an emergency department setting

  • Mercedeh Shanechi (a1), Onyinyechi Eke (a1) and Michael Gottlieb (a2)

Abstract

Clinical question

Does the analgesic effect of intravenous ketorolac differ if given in doses of 10, 15, or 30 mg to patients presenting to the emergency department with acute pain?

Article chosen

Motov S, Yasavolian M, Likourezos A, et al. Comparison of intravenous ketorolac at three single-dose regimens for treating acute pain in the emergency department: a randomized controlled trial. Ann Emerg Med 2017;70(2):177-84.

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Copyright

Corresponding author

*Correspondence to: Dr. Mercedeh Shanechi, Cook County (Stroger) Hospital, Department of Emergency Medicine, 1900 W. Polk St., 10th Floor, Chicago, IL, 60612, United States; Email: mshanechi@cookcountyhhs.org

References

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2. Brown, CR, Moodie, JE, Wild, VM, Bynum, LJ. Comparison of intravenous ketorolac tromethamine and morphine sulfate in the treatment of postoperative pain. Pharmacotherapy 1990;10(6(Pt 2)):116S-121S.
3. Reuben, SS, Connelly, NR, Lurie, S, Klatt, M, Gibson, CS. Dose-response of ketorolac as an adjunct to patient-controlled analgesia morphine in patients after spinal fusion surgery. Anesth Analg 1998;87(1):98-102.
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5. Vadivelu, N, Chang, D, Helander, EM, et al. Ketorolac, oxymorphone, tapentadol, and tramadol: a comprehensive review. Anesthesiol Clin 2017;35(2):e1-e20.
6. Soleyman-Zomalan, E, Motov, S, Likourezos, A, et al. Patterns of Ketorolac dosing by emergency physicians. World J Emerg Med 2017;8(1):43-46.
7. Bijur, PE, Latimer, CT, Gallagher, EJ. Validation of a verbally administered numerical rating scale of acute pain for use in the emergency department. Acad Emerg Med 2003;10(4):390-392.
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9. Strom, BL, Berlin, JA, Kinman, JL, et al. Parenteral ketorolac and risk of gastrointestinal and operative site bleeding. A postmarketing surveillance study. JAMA 1996;275(5):376-382.
10. Gales, BJ, Gales, MA. Death associated with inappropriate ketorolac dosing [letter]. Ann Pharmacother 1995;29(12):1299.
11. Toradol IV/IM [package insert]. Nutley, NJ: Roche Laboratories; 1994.
12. Tramèr, MR, Williams, JE, Carroll, D, et al. Comparing analgesic efficacy of non-steroidal anti-inflammatory drugs given by different routes in acute and chronic pain: a qualitative systematic review. Acta Anaesthesiol Scand 1998;42(1):71-79.
13. Ong, CK, Lirk, P, Tan, CH, Seymour, RA. An evidence-based update on nonsteroidal anti-inflammatory drugs. Clin Med Res 2007;5(1):19-34.
14. Gillis, JC, Brogden, RN. Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management. Drugs 1997;53(1):139-188.
15. Brocks, DR, Jamali, F. Clinical pharmacokinetics of ketorolac tromethamine. Clin Pharmacokinet 1992;23(6):415-427.
16. Mroszczak, EJ, Jung, D, Yee, J, et al. Ketorolac tromethamine pharmacokinetics and metabolism after intravenous, intramuscular, and oral administration in humans and animals. Pharmacotherapy 1990;10(6(Pt 2)):33S-39S.

Keywords

Comparison of ketorolac dosing in an emergency department setting

  • Mercedeh Shanechi (a1), Onyinyechi Eke (a1) and Michael Gottlieb (a2)

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