Hostname: page-component-8448b6f56d-dnltx Total loading time: 0 Render date: 2024-04-24T23:46:55.026Z Has data issue: false hasContentIssue false

Cumulative and sensitisation effects of repeated applications of methomyl to the housefly, Musca domestica L. (Diptera: Muscidae)

Published online by Cambridge University Press:  10 July 2009

P. Gerolt
Affiliation:
Shell Research Limited, Shell Biosciences Laboratory, Sittingbourne, Kent, ME9 8AG, U.K..

Abstract

Abstract

Repeated sublethal doses of methomyl and certain of its analogues have been found fully cumulative against adult Musca domestica L. Successive dose treatments were at least as effective as, and in many cases more effective than, a single dose treatment of equivalent amount. Treatment with sublethal doses of methomyl also enhanced the efficacy of insecticides of other chemical groups applied subsequently. The cumulative effect is not due to persistence of the compound in the tissues, to interference with the detoxification mechanism for the insecticides or to prolonged inhibition of acetylcholinesterase. Only a very tentative explanation can be suggested at present.

Type
Original Articles
Copyright
Copyright © Cambridge University Press 1977

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Booth, G. M. & Metcalf, R. L.. (1970). Histochemical evidence for localized inhibition of cholinesterase in the house fly.—Ann. ent. Soc. Am. 63, 197204.CrossRefGoogle ScholarPubMed
Brady, U. E.. (1970). Localization of cholinesterase activity in housefly thoraces: inhibition of cholinesterase with organophosphate compounds.—Entomol. exp. appl. 13, 423431.CrossRefGoogle Scholar
Chadwick, L. E.. (1963). Cholinesterases and anticholinesterase agents.—Handb. exp. Pharmak. 15, 741798.CrossRefGoogle Scholar
Chang, S. C. & Crowell, H. H.. (1953). Effect of successive treatments of DDT on individual susceptibility in the American cockroach.—J. econ. Ent. 46, 467472.CrossRefGoogle Scholar
Chang, S. C. & Kearns, C. W.. (1964). Metabolism in vivo of C14–labelled pyrethrin I and cinerin I by house flies with special reference to the synergistic mechanism.—J. econ. Ent. 57, 397–104.CrossRefGoogle Scholar
Cohen, A. J.. & Smith, J. N..(1961). Fate of aldrin and dieldrin in locusts.—Nature. Lond. 189, 600601.CrossRefGoogle Scholar
Gerolt, P.. (1965). The fate of dieldrin in insects.—J. econ. Ent. 58, 849857.CrossRefGoogle ScholarPubMed
Gerolt, P.. (1972). Mode of entry of oxime carbamates into insects.—Pestic. Sci. 3, 4355.CrossRefGoogle Scholar
Gerolt, P.. (1976a). Latent toxicity of dieldrin in the housefly, Musca domestica L. (Diptera, Muscidae).—Bull. ent. Res. 65, 651657.CrossRefGoogle Scholar
Gerolt, P.. (1976b). The mode of action of insecticides: accelerated water loss and reduced respiration in insecticide-treated Musca domestica L.—Pestic. Sci. 7, 604620.CrossRefGoogle Scholar
Grundfest, H.. (1964). Effects of drugs on the central nervous system.—A. Rev. Pharmacol. 4, 341364.CrossRefGoogle Scholar
Hadaway, A. B.. (1956). Cumulative effect of sub-lethal doses of insecticides on houseflies.—Nature, Lond. 178, 149150.CrossRefGoogle Scholar
Koelle, G. B.. (1962). A new general concept of the neurohumoral functions of acetylcholine and acetylcholinesterase.—J. Pharm. Pharmac. 14, 6590.CrossRefGoogle Scholar
Koelle, G. B.. (1963). Cytological distribution and physiological functions of cholinesterases.—Handb. exp. Pharmak. 15, 187298.CrossRefGoogle Scholar
MacCuaig, R. D..(1957). The cumulative toxicity of γ-BHC and diazinon applied in small doses to locusts.—Ann. appl. Biol. 45, 114121.CrossRefGoogle Scholar
MacCuaig, R. D. & Sawyer, K. F..(1957). The cumulative toxicity of dinitro-o-cresol applied in small doses to locusts.—Bull. ent. Res. 48, 435445.CrossRefGoogle Scholar
Molloy, F. M.. (1961). The histochemistry of the cholinesterases in the central nervous system of susceptible and resistant strains of the house-fly, Musca domestica L., in relation to diazinon poisoning.—Bull. ent. Res. 52, 667681.CrossRefGoogle Scholar
O'brien, R. D.. (1967). Insecticides: Action and Metabolism.—332 pp. New York, Academic Press.Google Scholar
Perry, A. S.. (1960). Metabolism of insecticides by various insect species.—J. Agric. Fd.Chem. 8, 266272.CrossRefGoogle Scholar
Shipp, E. & Otton, J..(1976a). Orcadian rhythms of sensitivity to insecticides in Musca domestica (Diptera, Muscidae).—Entomologia exp. appl. 19, 163171.CrossRefGoogle Scholar
Shipp, E. & Otton, J..(1976b). Diel changes in DDT absorption and breakdown rates and respiratory rhythm in the housefly, Musca domestica.—Entomologia exp. appl. 19, 235242.CrossRefGoogle Scholar
Smith, D. S.. & Treherne, J. E..(1965). The electron microscope localization of cholinesterase activity in the central nervous system of an insect, Periplaneta americana L.—J. Cell. Biol. 26, 445465.CrossRefGoogle Scholar