Hostname: page-component-848d4c4894-ndmmz Total loading time: 0 Render date: 2024-05-12T06:56:24.080Z Has data issue: false hasContentIssue false

Non-nutritional (novel) techniques for manipulation of milk composition

Published online by Cambridge University Press:  27 February 2018

C.H. Knight
Affiliation:
Hannah Research Institute, Ayr, Scotland KA6 5HL, U.K.
A. Sorensen
Affiliation:
Hannah Research Institute, Ayr, Scotland KA6 5HL, U.K.
D.D. Muir
Affiliation:
Hannah Research Institute, Ayr, Scotland KA6 5HL, U.K.
Get access

Abstract

This review considers the control of milk composition by endocrine factors and local mechanisms operating within the udder, and the impact of management systems and the environment on these control systems. Much less is known about control of milk composition than yield, although one can propose that prolactin is more concerned with control of lactose and protein secretion whilst growth hormone has a bigger role to play in fat secretion. Molecular biological approaches have the potential to increase understanding and, in the distant but foreseeable future, to manipulate milk composition on a commercial scale. The feedback inhibitor of lactation (FIL), which is responsible for local control of milk yield, has equal effects on lactose, fat and protein secretion, so changes in milking frequency do not alter gross milk composition. During the course of lactation the processing properties of milk gradually deteriorate as a consequence of proteolytic degradation of caseins, but new research shows that this can largely be prevented by milking thrice–daily. This has significant implications for future milking strategies such as robotic milking and extended lactation.

Type
Opportunities for non–nutritional manipulation of milk composition and application of current technology in practice
Copyright
Copyright © British Society of Animal Science 2000

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aharoni, Y., Brosh, A. and Ezra, E. 1999. Effects of heat load and photoperiod on milk yield and composition in three dairy herds in Israel. Animal Science 69: 37-47.CrossRefGoogle Scholar
Andrews, A.T. and Alichanidis, E. 1983. Proteolysis of caseins and the proteose-peptone fraction of bovine milk. Journal of Dairy Research 50: 275290.Google Scholar
Anon “Dairy Facts and Figures,” Federation of UK Milk Marketing Boards, 1991.Google Scholar
Bauman, D.E. 1992. Bovine somatotrophin: review of an emerging animal technology. Journal of Dairy Science 75: 34323451.Google Scholar
Bauman, D.E., Everett, R.W., Weiland, W.H. and Collier, R.J. 1999. Production responses to bovine somatotrophin in Northeast dairy herds. Journal of Dairy Science 82: 25642573.CrossRefGoogle ScholarPubMed
Bickerstaffe, R., Annison, E.F. and Linzell, J.L. 1974. The metabolism of glucose, acetate, lipids and amino acids in lactating dairy cows. Journal of Agricultural Science 82: 7185.Google Scholar
Brown, J.R., Law, A.J.R. and Knight, C.H. 1995. Changes in casein composition of goats’ milk during the course of lactation: physiological inferences and technological implications. Journal of Dairy Research 62: 431439.Google Scholar
Campos, M.S., Wilcox, C.J., Head, H.H., Webb, D.W. and Hayen, J. 1994. Effects on production of milking three times daily on first lactation Holsteins and Jerseys in Florida. Journal of Dairy Science 77: 770773.CrossRefGoogle ScholarPubMed
Chalupa, W. and Galligan, D.T. 1989. Nutritional implications of somatotropin for dairy cows. Journal of Dairy Science 72: 25102524.Google Scholar
Coulon, J.B., Perochon, L. and Lescourret, F. 1995. Modelling the effect of the stage of pregnancy on dairy cow's milk yield. Animal Science 60: 401408.Google Scholar
Dahlborn, K. 1987. Effect of temporary food or water deprivation on milk secretion and milk composition in the goat. Journal of Dairy Research 54: 153163.Google Scholar
Dalgleish, D.G. 1992. Bovine milk protein properties and the manufacturing quality of milk. Livestock Production Science 35: 7593.Google Scholar
Davis, S.R. 1998. Once-daily milking of dairy cows: an appraisal. Proceedings of the New Zealand Society of Animal Production (In press).Google Scholar
Davis, S.R., Collier, R.J., McNamara, J.P., Head, H.H. and Sussman, W. 1988. Effects of thyroxine and growth hormone treatment of dairy cows on milk yield, cardiac output and mammary blood flow. Journal of Animal Science 66: 7079.Google Scholar
Eppard, P.J., Bauman, D.E., Bitman, J., Wood, L., Akers, R.M. and House, W.A. 1985. Effect of bovine growth hormone on milk composition: α-lactalbumin, fatty acids and mineral elements. Journal of Dairy Science 68: 30473054.Google Scholar
Fleet, I.R., Goode, J.A., Hamon, M.H., Laurie, M.S., Linzell, J.L. and Peaker, M. 1975. Secretory activity of goat mammary glands during pregnancy and the onset of lactation. Journal of Physiology 251: 763773.Google Scholar
Flint, D.J. and Gardner, M.J. 1994. Evidence that growth hormone stimulates milk synthesis by direct action on the mammary gland and that prolactin exerts effects on milk secretion by maintenance of mammary DNA content and tight junction status. Endocrinology 135: 11191124.Google Scholar
Flint, D.J. and Knight, C.H. 1997. Interactions of prolactin and growth hormone (GH) in the regulation of mammary gland function and epithelial cell survival. Journal of Mammary Gland Biology and Neoplasia 2: 4148.Google Scholar
Fujita, H., Matsuoka, S., Takahashi, J., Suzuki, T. and Fujita, T. 1982. Changes in metabolism and productive performance of lactating dairy cows in cold environment. Research Bulletin of the Olsihiro University 12: 323329.Google Scholar
Griinari, J.M., McGuire, M.A., Dwyer, D.A., Bauman, D.E. and Palmquist, D.L. 1997. Role of insulin in the regulation of milk fat synthesis in dairy cows. Journal of Dairy Science 80: 10761084.Google Scholar
Harris, S., McClenaghan, M., Simons, J.P., Ali, S. and Clark, A.J. 1991. Developmental regulation of the sheep β-lactoglobulin gene in the mammary gland of transgenic mice. Developmental Genetics 12: 299307.Google Scholar
Henderson, A.J., Blatchford, D.R. and Peaker, M. 1983. The effects of milking thrice instead of twice daily on milk secretion in the goat. Quarterly Journal of Experimental Physiology 68: 645652.Google Scholar
Hillerton, J.E., Knight, C.H., Turvey, A., Wheatley, S.D. and Wilde, C.J. 1990. Milk yield and mammary function in dairy cows milked four times daily. Journal of Dairy Research 57: 285294.Google Scholar
Holmes, C.W., Wilson, G.F., MacKenzie, D.D.S. and Purchas, J. 1992. The effects of milking once daily throughout lactation on performance of dairy cows grazing pasture. Proceedings of the New Zealand Society for Animal Production 52: 1316.Google Scholar
Ipema, A.H. and Benders, E. 1992. Production, duration of machine milking and teat quality of dairy cows milked 2, 3 or 4 times daily with variable intervals. International Symposium on Prospects for Automatic Milking. Wageningen, The Netherlands. EAAP, p 244-252.Google Scholar
Johnson, H.D., Kibler, H.H., Berry, I.L., Wayman, O. and Merilan, C.P. 1966. Environmental physiology and shelter engineering with special reference to domestic animals. LXX Temperature and controlled feeding: Effects on lactation and related physiological reactions of cattle. Research Bulletin of the Missouri Agricultural Experimental Station 902: 127.Google Scholar
Klei, L.R., Lynch, J.M., Barbano, D.M., Oltenacu, P.A., Lednor, A.J. and Bandler, D.K. 1997. Influence of milking three times a day on milk quality. Journal of Dairy Science 80: 427436.Google Scholar
Knight, C.H. 1994. Physiological manipulation of milk protein content. Animal Production 58: 428.Google Scholar
Knight, C.H. 1998. Extended lactation. Hannah Research Institute Yearbook 1998: 3039.Google Scholar
Knight, C.H., Brown, J.R. and Dewhurst, R.J. 1995. Udder characteristics and relationship to efficiency of milk production. In Breeding and feeding the high genetic merit dairy cow. Occasional Publication No. 19 – British Society of Animal Science 1995, (ed Lawrence, T.L.J., Gordon, F.J. and Carson, A.) pp. 7985.Google Scholar
Knight, C.H., Hillerton, J.E., Teverson, R.M. and Winter, A. 1992. Biopsy of the bovine mammary gland. British Veterinary Journal 148: 129132.CrossRefGoogle ScholarPubMed
Knight, C.H., Peaker, M. and Wilde, C.J. 1998. Local control of mammary development and function. Reviews of Reproduction 3: 104112.Google Scholar
Kuhn, N. 1977. Lactogenesis: the search for trigger mechanisms in different species. In Comparative aspects of lactation, (ed Peaker, M.) pp. 165192. Academic Press, London.Google Scholar
Kuipers, A. and Rossing, W. 1996. Robotic milking of dairy cows. In Progress in dairy science, (ed Phillips, C.J.C.) pp. 263280. CAB International, Wallingford, Oxford.Google Scholar
Kunz, T.H., Oftedal, O.T., Robson, S.K., Kretzmann, M.B. and Kirk, C. 1995. Changes in milk composition during lactation in three species of insectivorous bat. Journal of Comparative Biochemistry and Physiology B 164: 543551.Google Scholar
L'Huillier, P.J., Soulier, S., Stinnakre, M.-G., Lepourry, L., Davis, S.R., Mercier, J.-C. and Vilotte, J.-L. 1996. Efficient and specific ribozyme-mediated reduction of bovine α-lactalbumin expression in double transgenic mice. Proceedings of the National Academy of Sciences of the USA 93: 66986703.Google Scholar
Lucey, J. 1996. Cheesemaking from grass based seasonal milk and problems associated with late-lactation milk. Journal of the Society of Dairy Technology 49: 5964.Google Scholar
Madon, R.J., Ensor, D.M., Knight, C.H. and Flint, D.J. 1986. Effects of an antiserum to rat growth hormone on lactation in the rat. Journal of Endocrinology 111: 117123.Google Scholar
Martyn, P. and Hansen, I.A. 1980. Initiation of fatty acid synthesis in rat mammary glands. Biochemical Journal 190: 171175.Google Scholar
Nostrand, S.D., Galton, D.M., Erb, H.N. and Bauman, D.E. 1991. Effects of daily exogenous oxytocin on lactation milk yield and composition. Journal of Dairy Science 74: 21192127.Google Scholar
O'Brien, B. 2000. Composition and processability of bovine milk from herds with different calving patterns. In Milk Composition. Occasional Publication No. 25 - British Society of Animal Science 2000, (ed Agnew, R.E., Agnew, K.W. and Fearon, A.M.) pp. 7786.Google Scholar
Oftedal, O.T. 1984. Milk composition, milk yield and energy output at peak lactation: a comparative review. Symposia of the Zoological Society of London 51: 3385.Google Scholar
Peaker, M. 1977. The aqueous phase of milk: ion and water transport. Symposia of the Zoological Society of London 41: 113134.Google Scholar
Phillips, C.J.C. and Schofield, S.A. 1989. The effect of supplementary light on the production and behaviour of dairy cows. Animal Production 48: 293303.Google Scholar
Politis, I., Lachance, E., Block, E. and Turner, J.D. 1988. Plasmin/plasminogen in bovine milk: a relationship with involution. Journal of Dairy Science 72: 900906.Google Scholar
Rennison, M.E., Kerr, M., Addey, C.V.P., Handel, S.E., Turner, M.D., Wilde, C.J., and Burgoyne, R.D. 1993. Inhibition of constitutive protein secretion from lactating mouse mammary epithelial cells by FIL (feedback inhibitor of lactation), a secreted milk protein. Journal of Cell Science 106: 641648.Google Scholar
Sorensen, A., Muir, D.D. and Knight, C. 1999. Effects of milking frequency on milk proteins. 50th Annual Meeting of the European Association of Animal Production. Zurich, Wageningen Pers, p. 167.Google Scholar
Soulier, S., Lepourry, L., Stimnnakre, M.-G., Mercier, J.-C. and Vilotte, J.-L. 1997. Expression of a bovine α-lactalbumin transgene in α-lactalbumin-deficient mice can rescue lactation. In vivo relationship between bovine α-lactalbumin expression content and milk composition. Journal of Dairy Research 64: 145148.Google Scholar
Soulier, S., Stinnakre, M.-G., Lepourry, L., Mercier, J.-C. and Vilotte, J.-L. 1999. Use of doxycycline-controlled gene expression to reversibly alter milk-protein composition in transgenic mice.Google Scholar
Stacey, A., Schnieke, A., Kerr, M., Scott, A., McKee, C., Cottingham, I., Binas, B., Wilde, C. and Colman, A. 1995. Lactation is disrupted by alpha-lactalbumin deficiency and can be restored by human alpha-lactalbumin gene replacement in mice. Proceedings of the National Academy of Sciences of the USA 92: 28352839.Google Scholar
Stelwagen, K., Farr, V.C., McFadden, H.A., Proseer, C.G. and Davis, S.R. 1997. Time course of milk accumulation-induced opening of mammary tight junctions, and blood clearance of milk components. American Journal of Physiology 273: R379R386.Google Scholar
Stinnakre, M.G., Vilotte, J.L., Soulier, S. and Mercier, J.C. 1994. Creation and phenotypic analysis of alpha-lactalbumin-deficient mice. Proceedings of the National Academy of Sciences of the USA 91: 65446548.Google Scholar
Strong, C.R. and Dils, R. 1972. Fatty acid biosynthesis in rabbit mammary gland during pregnancy and early lactation. Biochemical Journal 128: 13031309.Google Scholar
Tucker, H.A. 1985. Photoperiodic influences on milk production in dairy cows. In Recent Advances in Animal Nutrition 1985, (ed Haresign, W. and Cole, D.J.A.) pp. 211221. Butterworths, London.Google Scholar
Van Soest, P.J. 1963. Ruminant fat metabolism with particular reference to factors affecting low milk fat and feed efficiency. Journal of Dairy Science 46: 204216.Google Scholar
Vilotte, J.-L., Soulier, S., Persuy, M.-A., Lepourry, L., KLegrain, S., Printz, C., Stinnakre, M.-G., L'Huillier, P. and Mercier, J.-C. 1997. Application of transgenesis to modifying milk protein composition. In Milk composition, production and biotechnology; (ed Welch, R.A.S.; Burns, D.J.W.; Davis, S.R.; Popay, A.I. and Prosser, C.G.) pp. 231242. CAB International, Wallingford, Oxford.Google Scholar
Welch, R.A.S., Burns, D.J.W., Davis, S.R., Popay, A.I. and Prosser, C.G. 1997. Milk composition, production and biotechnology. CAB International, Wallingford, Oxford.Google Scholar
White, J.M. 1984. Some effects of cold exposure on milk secretion in the goat. MSc., University of Glasgow, 1984.Google Scholar
Wilde, C.J., Addey, C.V.P., Boddy, L.M. and Peaker, M. 1995. Autocrine regulation of milk secretion by a protein in milk. Biochemical Journal 305: 5158.Google Scholar
Wilde, C.J., Henderson, A.J. and Knight, C.H. 1986. Metabolic adaptations in goat mammary tissue during pregnancy and lactation. Journal of Reproduction and Fertility 76: 289298.Google Scholar
Wilde, C.J., Henderson, A.J., Knight, C.H., Blatchford, D.R., Faulkner, A. and Vernon, R.J. 1987. Effects of long-term thrice-daily milking on mammary enzyme activity, cell population and milk yield. Journal of Animal Science 64: 533539.CrossRefGoogle ScholarPubMed