Skip to main content Accessibility help
×
×
Home

Higher serum carotenoid concentrations associated with a lower prevalence of the metabolic syndrome in middle-aged and elderly Chinese adults

  • Jun Liu (a1) (a2), Wen-qi Shi (a1), Yi Cao (a1), Li-ping He (a1) (a3), Ke Guan (a1), Wen-hua Ling (a1) and Yu-ming Chen (a1)...

Abstract

The association between serum carotenoids and the metabolic syndrome (MetS) remains uncertain, and little is known about this relationship in the Chinese population. The present study examined the association between serum carotenoid concentrations and the MetS in Chinese adults. We conducted a community-based cross-sectional study in which 2148 subjects (1547 women and 601 men) aged 50–75 years were recruited in urban Guangzhou, China. Dietary data and other covariates were collected during face-to-face interviews. Blood pressure, waist circumference, blood lipids, glucose and serum carotenoids (α-, β-carotene, β-cryptoxanthin, lycopene and lutein/zeaxanthin) were examined. We found dose–response inverse relationships between individual serum carotenoid concentrations and total carotenoids and the prevalence of the MetS after adjusting for potential confounders (P for trend < 0·001). The OR of the MetS for the highest (v. lowest) quartile were 0·31 (95 % CI 0·20, 0·47) for α-carotene, 0·23 (95 % CI 0·15, 0·36) for β-carotene, 0·44 (95 % CI 0·29, 0·67) for β-cryptoxanthin, 0·39 (95 % CI 0·26, 0·58) for lycopene, 0·28 (95 % CI 0·18, 0·44) for lutein+zeaxanthin and 0·19 (95 % CI 0·12, 0·30) for total carotenoids. Higher concentrations of each individual carotenoid and total carotenoids were significantly associated with a decrease in the number of abnormal MetS components (P for trend < 0·001–0·023). Higher serum carotenoid levels were associated with a lower prevalence of the MetS and fewer abnormal MetS components in middle-aged and elderly Chinese adults.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Higher serum carotenoid concentrations associated with a lower prevalence of the metabolic syndrome in middle-aged and elderly Chinese adults
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Higher serum carotenoid concentrations associated with a lower prevalence of the metabolic syndrome in middle-aged and elderly Chinese adults
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Higher serum carotenoid concentrations associated with a lower prevalence of the metabolic syndrome in middle-aged and elderly Chinese adults
      Available formats
      ×

Copyright

Corresponding author

* Corresponding author: Professor Y.-m. Chen, fax +86 20 87330446, email chenyum@mail.sysu.edu.cn

References

Hide All
1 Suzuki, T, Hirata, K, Elkind, MS, et al. (2008) Metabolic syndrome, endothelial dysfunction, and risk of cardiovascular events: the Northern Manhattan Study (NOMAS). Am Heart J 156, 405410.
2 Reaven, G (2002) Metabolic syndrome: pathophysiology and implications for management of cardiovascular disease. Circulation 106, 286288.
3 Kereiakes, DJ & Willerson, JT (2003) Metabolic syndrome epidemic. Circulation 108, 15521553.
4 Gu, D, Reynolds, K, Wu, X, et al. (2005) Prevalence of the metabolic syndrome and overweight among adults in China. Lancet 365, 13981405.
5 He, Y, Jiang, B, Wang, J, et al. (2006) Prevalence of the metabolic syndrome and its relation to cardiovascular disease in an elderly Chinese population. J Am Coll Cardiol 47, 15881594.
6 Otani, H (2011) Oxidative stress as pathogenesis of cardiovascular risk associated with metabolic syndrome. Antioxid Redox Signal 15, 19111926.
7 Hopps, E, Noto, D, Caimi, G, et al. (2010) A novel component of the metabolic syndrome: the oxidative stress. Nutr Metab Cardiovasc Dis 20, 7277.
8 Amiri, F (2009) Metabolic syndrome, insulin resistance and oxidative stress: adding insights to improve cardiovascular prevention. J Hypertens 27, 13521354.
9 Young, AJ & Lowe, GM (2001) Antioxidant and prooxidant properties of carotenoids. Arch Biochem Biophys 385, 2027.
10 Fiedor, J & Burda, K (2014) Potential role of carotenoids as antioxidants in human health and disease. Nutrients 6, 466488.
11 Krinsky, NI & Johnson, EJ (2005) Carotenoid actions and their relation to health and disease. Mol Aspects Med 26, 459516.
12 Andersen, LF, Jacobs, DR Jr, Gross, MD, et al. (2006) Longitudinal associations between body mass index and serum carotenoids: the CARDIA study. Br J Nutr 95, 358365.
13 Gouranton, E, Thabuis, C, Riollet, C, et al. (2011) Lycopene inhibits proinflammatory cytokine and chemokine expression in adipose tissue. J Nutr Biochem 22, 642648.
14 Marcotorchino, J, Romier, B, Gouranton, E, et al. (2012) Lycopene attenuates LPS-induced TNF-alpha secretion in macrophages and inflammatory markers in adipocytes exposed to macrophage-conditioned media. Mol Nutr Food Res 56, 725732.
15 Ford, ES, Mokdad, AH, Giles, WH, et al. (2003) The metabolic syndrome and antioxidant concentrations: findings from the Third National Health and Nutrition Examination Survey. Diabetes 52, 23462352.
16 Beydoun, MA, Shroff, MR, Chen, X, et al. (2011) Serum antioxidant status is associated with metabolic syndrome among U.S. adults in recent national surveys. J Nutr 141, 903913.
17 Beydoun, MA, Canas, JA, Beydoun, HA, et al. (2012) Serum antioxidant concentrations and metabolic syndrome are associated among U.S. adolescents in recent national surveys. J Nutr 142, 16931704.
18 Sugiura, M, Nakamura, M, Ogawa, K, et al. (2008) Associations of serum carotenoid concentrations with the metabolic syndrome: interaction with smoking. Br J Nutr 100, 12971306.
19 Suzuki, K, Ito, Y, Inoue, T, et al. (2011) Inverse association of serum carotenoids with prevalence of metabolic syndrome among Japanese. Clin Nutr 30, 369375.
20 Coyne, T, Ibiebele, TI, Baade, PD, et al. (2009) Metabolic syndrome and serum carotenoids: findings of a cross-sectional study in Queensland, Australia. Br J Nutr 102, 16681677.
21 Czernichow, S, Vergnaud, AC, Galan, P, et al. (2009) Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adults. Am J Clin Nutr 90, 329335.
22 Grundy, SM (2008) Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol 28, 629636.
23 Rakugi, H & Ogihara, T (2005) The metabolic syndrome in the Asian population. Curr Hypertens Rep 7, 103109.
24 Povel, CM, Boer, JM, Reiling, E, et al. (2011) Genetic variants and the metabolic syndrome: a systematic review. Obes Rev 12, 952967.
25 Phillips, C, Lopez-Miranda, J, Perez-Jimenez, F, et al. (2006) Genetic and nutrient determinants of the metabolic syndrome. Curr Opin Cardiol 21, 185193.
26 Andreassi, MG (2009) Metabolic syndrome, diabetes and atherosclerosis: influence of gene–environment interaction. Mutat Res 667, 3543.
27 Ainsworth, BE, Haskell, WL, Herrmann, SD, et al. (2011) 2011 Compendium of Physical Activities: a second update of codes and MET values. Med Sci Sports Exerc 43, 15751581.
28 Zhang, CX & Ho, SC (2009) Validity and reproducibility of a food frequency questionnaire among Chinese women in Guangdong province. Asia Pac J Clin Nutr 18, 240250.
29 Yang, YX (2004) China Food Composition Table 2004. Beijing: Peking University Medical Press.
30 Burri, BJ, Dopler-Nelson, M & Neidllinger, TR (2003) Measurements of the major isoforms of vitamins A and E and carotenoids in the blood of people with spinal-cord injuries. J Chromatogr A 987, 359366.
31 Alberti, KG, Zimmet, P & Shaw, J (2006) Metabolic syndrome – a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med 23, 469480.
32 Ciccone, MM, Cortese, F, Gesualdo, M, et al. (2013) Dietary intake of carotenoids and their antioxidant and anti-inflammatory effects in cardiovascular care. Mediators Inflamm 2013, 782137.
33 Giordano, P, Scicchitano, P, Locorotondo, M, et al. (2012) Carotenoids and cardiovascular risk. Curr Pharm Design 18, 55775589.
34 Xu, X-R, Zou, Z-Y, Huang, Y-M, et al. (2012) Serum carotenoids in relation to risk factors for development of atherosclerosis. Clin Biochem 45, 13571361.
35 Hozawa, A, Jacobs, DR Jr, Steffes, MW, et al. (2007) Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: the Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTA) study. Clin Chem 53, 447455.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Type Description Title
WORD
Supplementary materials

Liu Supplementary Material
Table S1

 Word (115 KB)
115 KB

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed