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The effects of 12-week psyllium fibre supplementation or healthy diet on blood pressure and arterial stiffness in overweight and obese individuals

  • Sebely Pal (a1), Alireza Khossousi (a1), Colin Binns (a1), Satvinder Dhaliwal (a1) and Simone Radavelli-Bagatini (a1)...

Abstract

Endothelial dysfunction and increased arterial stiffness occur early in the pathogenesis of the metabolic syndrome and they are both powerful independent predictors of cardiovascular risk. A high-fibre diet has been correlated with lower BMI and a lower incidence of hyperlipidaemia, CVD, hypertension and diabetes. The present randomised, parallel-design study compared the effects of fibre intake from a healthy diet v. fibre supplement diets on blood pressure (BP) and vascular function over 12 weeks. Overweight and obese adults were randomised to one of three groups: control (with placebo), fibre supplement (FIB) or healthy eating group with placebo (HLT). Systolic blood pressure (SBP) was lower in the FIB group compared with the control group at week 6, but not at week 12. However, SBP was lower in the HLT group compared with control group at week 12. At week 6, the FIB group presented lower diastolic blood pressure and augmentation index compared with the control group, but this result did not persist to the end of the study. The present study did not show any improvements in BP or vascular function in overweight and obese individuals with psyllium fibre supplementation over 12 weeks of intervention. However, a healthy diet provided the greatest improvements in BP in overweight and obese subjects. Further research with hypertensive individuals is necessary to elucidate whether increased fibre consumption in the form of psyllium supplementation may provide a safe and acceptable means to reduce BP, vascular function and the risk of developing CVD.

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Corresponding author

*Corresponding author: Associate Professor S. Pal, fax +61 8 9266 2258, email s.pal@curtin.edu.au

References

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1 WHO (2002) Nutrition: Controlling the Global Obesity Epidemic. Geneva: World Health Organization.
2 Popkin, BM (2001) The nutrition transition and obesity in the developing world. J Nutr 131, 871S873S.
3 Isomaa, B, Almgren, P, Tuomi, T, et al. (2001) Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 24, 683689.
4 Grundy, SM (2004) Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 89, 25952600.
5 Cook, S, Hugli, O, Egli, M, et al. (2003) Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice. Swiss Med Wkly 133, 360363.
6 Appel, LJ, Brands, MW, Daniels, SR, et al. (2006) Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association. Hypertension 47, 296308.
7 Streppel, MT, Arends, LR, van't Veer, P, et al. (2005) Dietary fiber and blood pressure: a meta-analysis of randomized placebo-controlled trials. Arch Intern Med 165, 150156.
8 Greger, JL (1999) Nondigestible carbohydrates and mineral bioavailability. J Nutr 129, 1434S1435S.
9 Coudray, C, Demigne, C & Rayssiguier, Y (2003) Effects of dietary fibers on magnesium absorption in animals and humans. J Nutr 133, 14.
10 He, J, Klag, MJ, Whelton, PK, et al. (1995) Dietary macronutrients and blood pressure in southwestern China. J Hypertens 13, 12671274.
11 Stamler, J, Caggiula, AW & Grandits, GA (1997) Relation of body mass and alcohol, nutrient, fiber, and caffeine intakes to blood pressure in the special intervention and usual care groups in the Multiple Risk Factor Intervention Trial. Am J Clin Nutr 65, 338S365S.
12 Birketvedt, GS, Aaseth, J, Florholmen, JR, et al. (2000) Long-term effect of fibre supplement and reduced energy intake on body weight and blood lipids in overweight subjects. Acta Medica (Hradec Kralove) 43, 129132.
13 Eliasson, K, Ryttig, KR, Hylander, B, et al. (1992) A dietary fibre supplement in the treatment of mild hypertension. A randomized, double-blind, placebo-controlled trial. J Hypertens 10, 195199.
14 Streppel, MT, Arends, LR, van 't Veer, P, et al. (2005) Dietary fiber and blood pressure: a meta-analysis of randomized placebo-controlled trials. Arch Intern Med 165, 150156.
15 Ascherio, A, Rimm, EB, Giovannucci, EL, et al. (1992) A prospective study of nutritional factors and hypertension among US men. Circulation 86, 14751484.
16 WHO (2003) Diet, Nutrition and the Prevention of Chronic Diseases. Geneva: World Health Organization and FAO.
17 Burke, V, Hodgson, JM, Beilin, LJ, et al. (2001) Dietary protein and soluble fiber reduce ambulatory blood pressure in treated hypertensives. Hypertension 38, 821826.
18 Whelton, SP, Hyre, AD, Pedersen, B, et al. (2005) Effect of dietary fiber intake on blood pressure: a meta-analysis of randomized, controlled clinical trials. J Hypertens 23, 475481.
19 Solum, TT, Ryttig, KR, Solum, E, et al. (1987) The influence of a high-fibre diet on body weight, serum lipids and blood pressure in slightly overweight persons. A randomized, double-blind, placebo-controlled investigation with diet and fibre tablets (DumoVital). Int J Obes 11, Suppl. 1, 6771.
20 Schlamowitz, P, Halberg, T, Warnoe, O, et al. (1987) Treatment of mild to moderate hypertension with dietary fibre. Lancet 2, 622623.
21 Singh, RB, Rastogi, SS, Singh, NK, et al. (1993) Can guava fruit intake decrease blood pressure and blood lipids? J Hum Hypertens 7, 3338.
22 He, J, Streiffer, RH, Muntner, P, et al. (2004) Effect of dietary fiber intake on blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 22, 7380.
23 Galisteo, M, Sanchez, M, Vera, R, et al. (2005) A diet supplemented with husks of Plantago ovata reduces the development of endothelial dysfunction, hypertension, and obesity by affecting adiponectin and TNF-{alpha} in obese Zucker rats. J Nutr 135, 23992404.
24 Obata, K, Ikeda, K, Yamasaki, M, et al. (1998) Dietary fiber, psyllium, attenuates salt-accelerated hypertension in stroke-prone spontaneously hypertensive rats. J Hypertens 16, 19591964.
25 Li, J, Wang, J, Kaneko, T, et al. (2004) Effects of fiber intake on the blood pressure, lipids, and heart rate in Goto Kakizaki rats. Nutrition 20, 10031007.
26 He, J & Whelton, PK (1999) Effect of dietary fiber and protein intake on blood pressure: a review of epidemiologic evidence. Clin Exp Hypertens 21, 785796.
27 Alaimo, K, McDowell, MA, Briefel, RR, et al. (1994) Dietary intake of vitamins, minerals, and fiber of persons ages 2 months and over in the United States: Third National Health and Nutrition Examination Survey, Phase 1, 1988–91. Adv Data 128.
28 Marlett, JA, McBurney, MI & Slavin, JL (2002) Position of the American Dietetic Association: health implications of dietary fiber. J Am Diet Assoc 102, 9931000.
29 State of Victoria (2008) Fibre in Food. Victoria, Australia: Department of Primary Industries.
30 National Health and Medical Research Council (2005) Nutrient reference values for Australia and New Zealand [NHaMR Council, , editor]. Canberra: National Health and Medical Research Council.
31 Hense, HW (2004) Once at risk–forever at risk? The long-term impact of cardiovascular risk factors on death. Eur J Epidemiol 19, 409410.
32 Wilkinson, IB, Prasad, K, Hall, IR, et al. (2002) Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia. J Am Coll Cardiol 39, 10051011.
33 Blacher, J & Safar, ME (2005) Large-artery stiffness, hypertension and cardiovascular risk in older patients. Nat Clin Pract Cardiovasc Med 2, 450455.
34 Safar, ME (2001) Systolic blood pressure, pulse pressure and arterial stiffness as cardiovascular risk factors. Curr Opin Nephrol Hypertens 10, 257261.
35 Tomiyama, H, Hashimoto, H, Hirayama, Y, et al. (2006) Synergistic acceleration of arterial stiffening in the presence of raised blood pressure and raised plasma glucose. Hypertension 47, 180188.
36 Qureshi, G, Brown, R, Salciccioli, L, et al. (2007) Relationship between aortic atherosclerosis and non-invasive measures of arterial stiffness. Atherosclerosis 195, e190e194.
37 Casey, DP, Pierce, GL, Howe, KS, et al. (2007) Effect of resistance training on arterial wave reflection and brachial artery reactivity in normotensive postmenopausal women. Eur J Appl Physiol 100, 403408.
38 Greenwald, SE (2007) Ageing of the conduit arteries. J Pathol 211, 157172.
39 McEniery, CM, Wilkinson, IB & Avolio, AP (2007) Age, hypertension and arterial function. Clin Exp Pharmacol Physiol 34, 665671.
40 Ostmark, E, Harrisson, S, Wooley, KL, et al. (2007) Comb polymers prepared by ATRP from hydroxypropyl cellulose. Biomacromolecules 8, 11381148.
41 McEniery, CM & Cockcroft, JR (2007) Does arterial stiffness predict atherosclerotic coronary events? Adv Cardiol 44, 160172.
42 Safar, ME, Thomas, F, Blacher, J, et al. (2006) Metabolic syndrome and age-related progression of aortic stiffness. J Am Coll Cardiol 47, 7275.
43 Izzo, JL Jr & Shykoff, BE (2001) Arterial stiffness: clinical relevance, measurement, and treatment. Rev Cardiovasc Med 2, 2934, 37–40.
44 Scuteri, A, Najjar, SS, Muller, DC, et al. (2004) Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness. J Am Coll Cardiol 43, 13881395.
45 Arnett, DK, Tyroler, HA, Burke, G, et al. (1996) Hypertension and subclinical carotid artery atherosclerosis in blacks and whites. The Atherosclerosis Risk in Communities Study. ARIC Investigators. Arch Intern Med 156, 19831989.
46 Amar, J, Ruidavets, JB, Chamontin, B, et al. (2001) Arterial stiffness and cardiovascular risk factors in a population-based study. J Hypertens 19, 381387.
47 Benetos, A, Waeber, B, Izzo, J, et al. (2002) Influence of age, risk factors, and cardiovascular and renal disease on arterial stiffness: clinical applications. Am J Hypertens 15, 11011108.
48 Jenkins, DJ, Kendall, CW, Axelsen, M, et al. (2000) Viscous and nonviscous fibres, nonabsorbable and low glycaemic index carbohydrates, blood lipids and coronary heart disease. Curr Opin Lipidol 11, 4956.
49 Salas-Salvado, J, Bullo, M, Perez-Heras, A, et al. (2006) Dietary fibre, nuts and cardiovascular diseases. Br J Nutr 96, Suppl. 2, S46S51.
50 Jenkins, DJ, Wolever, TM, Rao, AV, et al. (1993) Effect on blood lipids of very high intakes of fiber in diets low in saturated fat and cholesterol. N Engl J Med 329, 2126.
51 Brown, L, Rosner, B, Willett, WW, et al. (1999) Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr 69, 3042.
52 Bingham, SA, Day, NE, Luben, R, et al. (2003) Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. Lancet 361, 14961501.
53 Ferrara, LA, Guida, L, Iannuzzi, R, et al. (2002) Serum cholesterol affects blood pressure regulation. J Hum Hypertens 16, 337343.
54 Creager, MA, Cooke, JP, Mendelsohn, ME, et al. (1990) Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest 86, 228234.
55 Laurenzi, M, Mancini, M, Menotti, A, et al. (1990) Multiple risk factors in hypertension: results from the Gubbio study. J Hypertens Suppl 8, S7S12.
56 Hayakawa, H & Raij, L (1999) Relationship between hypercholesterolaemia, endothelial dysfunction and hypertension. J Hypertens 17, 611619.
57 Vallance, P, Collier, J & Moncada, S (1989) Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet ii, 9971000.
58 Anderson, JW, Zeigler, JA, Deakins, DA, et al. (1991) Metabolic effects of high-carbohydrate, high-fiber diets for insulin-dependent diabetic individuals. Am J Clin Nutr 54, 936943.
59 Fukagawa, NK, Anderson, JW, Hageman, G, et al. (1990) High-carbohydrate, high-fiber diets increase peripheral insulin sensitivity in healthy young and old adults. Am J Clin Nutr 52, 524528.
60 Ferrannini, E, Buzzigoli, G, Bonadonna, R, et al. (1987) Insulin resistance in essential hypertension. N Engl J Med 317, 350357.
61 Pal, S, Khossousi, A, Binns, C, et al. (2011) The effect of a fibre supplement compared to a healthy diet on body composition, lipids, glucose, insulin and other metabolic syndrome risk factors in overweight and obese individuals. Br J Nutr 105, 90100.
62 Khossousi, A, Binns, CW, Dhaliwal, SS, et al. (2008) The acute effects of psyllium on postprandial lipaemia and thermogenesis in overweight and obese men. Br J Nutr 99, 10681075.
63 Blackwood, AD, Salter, J, Dettmar, PW, et al. (2000) Dietary fibre, physicochemical properties and their relationship to health. J R Soc Promot Health 120, 242247.
64 Lee, YM, Skurk, T, Hennig, M, et al. (2007) Effect of a milk drink supplemented with whey peptides on blood pressure in patients with mild hypertension. Eur J Nutr 46, 2127.
65 Wilkinson, IB, Franklin, SS, Hall, IR, et al. (2001) Pressure amplification explains why pulse pressure is unrelated to risk in young subjects. Hypertension 38, 14611466.
66 Galisteo, M, Duarte, J & Zarzuelo, A (2008) Effects of dietary fibers on disturbances clustered in the metabolic syndrome. J Nutr Biochem 19, 7184.
67 Reeves, RA (1991) A review of the stability of ambulatory blood pressure: implications for diagnosis of hypertension. Clin Invest Med 14, 251255.
68 Brown, DE, James, GD & Nordloh, L (1998) Comparison of factors affecting daily variation of blood pressure in Filipino-American and Caucasian nurses in Hawaii. Am J Phys Anthropol 106, 373383.
69 Jenkins, DJ, Kendall, CW, Vuksan, V, et al. (2002) Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial. Am J Clin Nutr 75, 834839.
70 Harriss, LR, English, DR, Powles, J, et al. (2007) Dietary patterns and cardiovascular mortality in the Melbourne Collaborative Cohort Study. Am J Clin Nutr 86, 221229.
71 Coudray, CDC & Rayssiguier, Y (2003) Effects of dietary fibers on magnesium absorption in animals and humans. J Nutr 133, 14.
72 Greger, J (1999) Nondigestible carbohydrates and mineral bioavailability. J Nutr 129, 1434S1435S.
73 Bessesen, D (2001) The role of carbohydrates in insulin resistance. J Nutr 131, 2782S2786S.
74 Ferrannini, E, Haffner, SM, Mitchell, BD, et al. (1991) Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome. Diabetologia 34, 416422.
75 King, DE, Mainous, AG III, Egan, BM, et al. (2005) Fiber and C-reactive protein in diabetes, hypertension, and obesity. Diabetes Care 28, 14871489.
76 Qi, L, Rimm, E, Liu, S, et al. (2005) Dietary glycemic index, glycemic load, cereal fiber, and plasma adiponectin concentration in diabetic men. Diabetes Care 28, 10221028.
77 Henry, RM, Kostense, PJ, Spijkerman, AM, et al. (2003) Arterial stiffness increases with deteriorating glucose tolerance status: the Hoorn Study. Circulation 107, 20892095.
78 Schram, MT, Henry, RM, van Dijk, RA, et al. (2004) Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes: the Hoorn Study. Hypertension 43, 176181.
79 Seals, DR, Moreau, KL, Gates, PE, et al. (2006) Modulatory influences on ageing of the vasculature in healthy humans. Exp Gerontol 41, 501507.
80 Brock, DW, Davis, CK, Irving, BA, et al. (2006) A high-carbohydrate, high-fiber meal improves endothelial function in adults with the metabolic syndrome. Diabetes Care 29, 23132315.
81 Wilkinson, IB, Qasem, A, McEniery, CM, et al. (2002) Nitric oxide regulates local arterial distensibility in vivo. Circulation 105, 213217.

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