Skip to main content Accessibility help
×
Home

Chromium supplementation in impaired glucose tolerance of elderly: effects on blood glucose, plasma insulin, C-peptide and lipid levels

  • Matti I. J. Uusitupa (a1), Leena Mykkänen (a2), Onni Siitonen (a2), Markku Laakso (a2), Helena Sarlund (a2), Päivi Kolehmainen (a2), Tiina Räsänen (a2), Jorma Kumpulainen (a3) and Kalevi Pyörälä (a2)...

Abstract

Altogether twenty-six elderly subjects (aged 65–74 years) with persistent impaired glucose tolerance (World Health Organization (1985) criteria) identified in a population-based study, were randomly treated either with chromium-rich yeast (160 μg Cr/d) or with placebo for 6 months. The 24 h urinary Cr increased from 0.13 (se 0.03) to 0.40 (se 0.06) μg/d in the Cr group (n 13) but no change was found in the placebo group (n 11) (0.13 (se 0.02) v. 0.11 (se 0.02) μg/d). No significant change was observed in the oral glucose tolerance test (glucose dose 75 g; 0, 1 and 2 h blood glucose respectively): 5.3 (se 0.1), 9.3 (se 0.3), 8.2 (se 0.3) mmol/l v. 5.0 (se 0.1), 8.5 (se 0.4), 7.3 (se 0.5) mmol/l in the Cr group; 4.9 (se 0.2), 9.2 (se 0.6), 8.1 (se 0.3) mmol/l v. 4.8 (se 0.2), 8.5 (se 0.5), 7.0 (se 0.6) mmol/l in the placebo group (baseline v. 6 months). Glycosylated haemoglobin, plasma insulin, C-peptide and apolipoprotein Al and B levels remained unchanged, and no improvement was seen in serum total cholesterol (6.2 (se 0.3) v. 6.4 (se 0.3) mmol/l for the Cr group, 6.2 (se 0.4) v. 6.5 (se 0.3) mmol/l for the placebo group), high-density-lipoprotein-cholesterol (1.1 (se 0.1) v. 1.2 (se 0.1) mmol/l for the Cr group, 1.0 (se 0.1) v. 1.1 (se 0.1) mmol/l for the placebo group) or triacylglycerols (2.5 (se 0.4) v. 2.0 (se 0.4) mmol/l for the Cr group, 2.4 (se 0.2) v. 2.5 (se 0.2) mmol/l for the placebo group). The present results indicate that Cr supplementation does not improve glucose tolerance or serum lipid levels in elderly subjects with stable impaired glucose tolerance.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Chromium supplementation in impaired glucose tolerance of elderly: effects on blood glucose, plasma insulin, C-peptide and lipid levels
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Chromium supplementation in impaired glucose tolerance of elderly: effects on blood glucose, plasma insulin, C-peptide and lipid levels
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Chromium supplementation in impaired glucose tolerance of elderly: effects on blood glucose, plasma insulin, C-peptide and lipid levels
      Available formats
      ×

Copyright

References

Hide All
Anderson, R. A. (1981). Nutritional role of chromium. Science of the Total Environment 17, 1329.
Anderson, R. A., Polansky, M. M., Bryden, N. A., Roginski, E. E., Mertz, W. & Glinsman, W. H. (1983). Chromium supplementation of human subjects: effects on glucose, insulin and lipid variables. Metabolism 32, 894899.
Avogaro, P., Bon, G. B., Cazzolato, G. & Quinci, G. B. (1979). Are apolipoproteins better discriminators than lipids for atherosclerosis? Lancet i, 901903.
Brown, R. O., Forloines-Lynn, S., Cross, R. E. & Heizer, W. D. (1986). Chromium deficiency after long-term total parenteral nutrition. Digestive Diseases and Sciences 31, 661664.
De Fronzo, R. A. (1981). Glucose tolerance and aging. Diabetes Care 4, 493501.
Doisy, R. J., Streeten, D. H. P., Freiberg, T. M. & Schneider, A. J. (1976). Chromium metabolism in man and biological effects. In Trace Elements in Human Health and Disease, vol. 2, pp. 79104 [Prasad, A. S. and Oberleas, D., editors]. New York: Academic Press.
Donaldson, D. L., Lee, D. E., Smith, C. C. & Rennert, O. M. (1985). Glucose tolerance and plasma lipid distributions in rats fed on a high sucrose, high cholesterol, low Cr diet. Metabolism 34, 10861093.
Freund, H., Atamiam, S. & Fischer, J. E. (1979). Chromium deficiency during total parenteral nutrition. Journal of the American Medical Association 241, 496498.
Fruchart, J. C., Kora, I., Cachera, C., Clavey, V., Duthilleul, P. & Moschetto, Y. (1982). Simultaneous measurement of plasma apolipoproteins A I and B by electroimmunoassay. Clinical Chemistry 28, 5962.
Glinsman, W. H. & Mertz, W. (1966). Effect of trivalent chromium on glucose tolerance. Metabolism 15, 510520.
Jeejeebhoy, K. N., Chu, R. C., Marliss, E. B., Greenberg, G. R. & Bruce-Robertson, A. (1977). Chromium deficiency, glucose intolerance, and neuropathy reversed by chromium supplementation, in a patient receiving long term parenteral nutrition. American Journal of Clinical Nutrition 30, 531538.
Kumpulainen, J., Lehto, J., Uusitupa, M., Vuori, E. & Koivistoinen, P. (1983). Determination of chromium in human milk, serum and urine by electrothermal atomic absorption spectrometry without preliminary ashing. Science of the Total Environment 31, 7180.
Kumpulainen, J., Vuori, E., Mäkinen, S. & Kara, R. (1980). Dietary chromium intake of lactating Finnish mothers: effect on the Cr content of their breast milk. British Journal of Nutrition 44, 257263.
Levine, R. A., Streeten, H. P. & Doisy, R. J. (1968). Effects of oral chromium supplementation on the glucose tolerance of elderly subjects. Metabolism 17, 114125.
Mertz, W. (1979). Chromium -an overview. In Chromium in Nutrition and Metabolism, pp. 114 [Shapcott, D. and Hubert, J., editors]. Amsterdam: Elsevier/North-Holland Biochemical Press.
Mykkänen, L., Laakso, M., Uusitupa, M. & Pyörälä, K. (1989). Prevalence of impaired glucose tolerance and diabetes in elderly patients in East Finland. Contribution of overall and central obesity and family history of diabetes. Diabetologia 32, 520A.
National Research Council (1989). Recommended Dietary Allowances, 10th ed. Washington, DC: National Academy of Sciences.
Offenbacher, E. G. & Pi-Sunyer, F. X. (1980). Beneficial effects of chromium-rich yeast on glucose tolerance and blood lipids in elderly subjects. Diabetes 29, 919925.
Offenbacher, E. G. & Pi-Sunyer, F. X. (1988). Chromium in human nutrition. Annual Review of Nutrition 8, 543563.
Offenbacher, E. G., Rinko, C. J. & Pi-Sunyer, F. X. (1985). The effects of inorganic chromium and brewer's yeast on glucose tolerance, plasma lipids, and plasma chromium in elderly subjects. American Journal of Clinical Nutrition 42, 454461.
Rabinowitz, M. B., Gonick, H. C., Levin, S. R. & Davidson, M. D. (1983). Effects of chromium and yeast supplements on carbohydrate and lipid metabolism in diabetic men. Diabetes Care 6, 319327.
Riales, R. & Albrink, M. J. (1981). Effects of chromium chloride supplementation on glucose tolerance and serum lipids including high-density lipoprotein of adult men. American Journal of Clinical Nutrition 34, 26702678.
Röschlau, P., Bernt, E. & Gruber, W. (1974). Enzymatische Bestimmung des Gesamt-Cholesterins in Serum. Zeitschrift für Klinische Chemie Klinische Biochemie 12, 403407.
Schwarz, K. & Mertz, W. (1959). Chromium III and the glucose tolerance factor. Archives of Biochemistry and Biophysics 85, 292295.
Sherman, L., Glennon, J. A., Brech, W. J., Klomberg, G. H. & Gordon, E. S. (1968). Failure of trivalent chromium to improve hyperglycemia in diabetes mellitus. Metabolism 17, 439442.
Uusitupa, M., Kumpulainen, J., Voutilainen, E., Hersio, K., Sarlund, H., Pyörälä, K., Koivistoinen, P. & Lehto, J. (1983). Effect of inorganic chromium supplementation on glucose tolerance, insulin response, and serum lipids in non-insulin-dependent diabetics. Amercican Journal of Clinical Nutrition 38, 404410.
Varo, P. & Koivistoinen, P. (1980). General discussion and nutritional evaluations. In [Koivistoinen, P., editor]. Mineral Element Composition of Finnish Foods. Acta Agricola Scandinavica Suppl. 22, 165171.
Versieck, J., Vanballenberghe, L., de Kasel, A., Hoste, J., Wallaeys, B., Vandenhaute, J., Baeck, W., Steyaert, H., Byrne, A. R. & Sunderman, F. Jr (1988). Certification of a second-generation biological reference material (Freeze-dried human serum) for trace element determinations. Analytica Chimica Acta 204, 6375.
Vuori, E. & Kumpulainen, J. (1987). A new low level of chromium in human liver and spleen. Trace Elements in Medicine 4, 8891.
Wahlefeld, A. W. (1974). Triglycerides. Determination after enzymatic hydrolysis. In Methods in Enzymatic Analysis, pp. 18311835, [Bergmeyer, H. U., editor]. New York: Academic Press.
World Health Organization (1985). Diabetes Mellitus. Report of a WHO Study Group. Technical Report Series no. 727. Geneva: WHO.

Keywords

Chromium supplementation in impaired glucose tolerance of elderly: effects on blood glucose, plasma insulin, C-peptide and lipid levels

  • Matti I. J. Uusitupa (a1), Leena Mykkänen (a2), Onni Siitonen (a2), Markku Laakso (a2), Helena Sarlund (a2), Päivi Kolehmainen (a2), Tiina Räsänen (a2), Jorma Kumpulainen (a3) and Kalevi Pyörälä (a2)...

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed