Skip to main content Accessibility help
×
Home

Alterations in endothelium-associated proteins and serum thyroid hormone concentrations in anorexia nervosa

  • Gen Komaki (a1), Hajime Tamai (a1), Toshio Mukuta (a1), Nobuyuki Kobayashi (a1), Kenji Mori (a1), Tetsuya Nakagawa (a1) and Lindy F. Kumagai (a2)...

Abstract

Plasma concentrations of endothelium-associated proteins (EAP) (plasma fibronectin (PFN), angio-tensin-converting enzyme, factor VIII-related antigen (F VIII-R:Ag)) and tissue plasminogen activator and serum thyroid hormone concentrations were studied in nine patients with anorexia nervosa (AN), before and after weight gain. Before weight gain (-35.9 (se 2.3)% of standard body-weight) PFN was significantly reduced and F VIII-R:Ag was significantly increased in AN patients compared with the concentrations in control subjects (211.5 (se 14.9) v. 274.7 (se 16.6) μg/ml, P < 0.05; 129.2 (se 14.1) v. 88.2 (se 9.7)%, P <0.05 respectively). Serum triiodothyronine (T3) and free T3 levels were also significantly lower before weight gain in AN patients (0.85 (se 0.07) v. 1.53 (se 0.08) nmol/l, P < 0.001; 2.57 (se 0.23) v. 5.31 (se 0.34) pmol/l, P < 0.001 respectively), although serum thyroxine (T4), free T4, and thyrotropin concentrations were within the normal range throughout the study periods. Following weight gain, PFN and F VIII-R: Ag concentrations normalized as did the thyroid hormone levels. The incremental changes in PFN levels correlated significantly with those in serum thyroid hormone concentrations (T3, r 0.79, P <0.01; free T3, r 0.84, P < 0.01). These findings suggest that PFN levels may be directly related to serum T3 concentrations in AN patients.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Alterations in endothelium-associated proteins and serum thyroid hormone concentrations in anorexia nervosa
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Alterations in endothelium-associated proteins and serum thyroid hormone concentrations in anorexia nervosa
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Alterations in endothelium-associated proteins and serum thyroid hormone concentrations in anorexia nervosa
      Available formats
      ×

Copyright

References

Hide All
Alexander, C. M., Lum, S. M. C., Rhodes, J., Boarman, C., Nicoloff, J. T. & Kumar, D. (1983). Rapid increase in both plasma fibronectin and serum triiodothyronine associated with treatment of diabetic ketoacidosis. Journal of Clinical Endocrinology and Metabolism 56, 279282.
American Psychiatric Association (1987). Diagnostic and Statistical Manual of Mental Disorders, 3rd ed. (revised) (DSM-IIIR). Washington, DC: American Psychiatric Association.
Azuma, H., Takeichi, T., Ohara, T. & Shirakami, A. (1987). Metabolism of plasma fibronectin in rabbits with experimental hyperthyroidism and hypothyroidism. Metabolism 36, 777780.
Bhanji, S. & Mattingly, D. (1988). Haematology and immunology. Medical Aspects of Anorexia Nervosa, pp. 5562. London: Wright.
Bergsdorf, N., Nilsson, T. & Wallé, P. (1983). An enzyme-linked immunosorbent assay for determination of tissue plasminogen activator applied to patients with thromboembolic disease. Thrombosis and Haemostasis 50, 740744.
Brent, G. A., Hershman, J. M., Reed, A. W., Sastre, A. & Lieberman, J. (1984). Serum angiotensin-converting enzyme in severe nonthyroidal illnesses associated with low serum thyroxin concentration. Annals of Internal Medicine 100, 680683.
Chopra, I. J., Chopra, U., Smith, S. R., Reza, M. & Solomon, D. H. (1975). Reciprocal changes in serum concentrations of 3,3′,5′-triiodothyronine (Reverse T3) and 3, 3′,5′-triiodothyronine (T3) in systemic illness. Journal of Clinical Endocrinology and Metabolism 41, 10431049.
Curran-Celentano, J., Erdman, J. W., Nelson, R. A. & Grater, S. J. E. (1985). Alterations in vitamin A and thyroid hormone status in anorexia nervosa and associated disorders. American Journal of Clinical Nutrition 42, 11831191.
Graninger, W., Pirich, K., Derfler, K. & Waldhäusl, W. (1985). Plasma fibronectin and thyroid function. Journal of Clinical Pathology 38, 6467.
Graninger, W., Pirich, K. R., Speiser, W., Deutsch, E. & Waldhäusl, W. K. (1986). Effect of thyroid hormones on plasma protein concentrations in man. Journal of Clinical Endocrinology and Metabolism 63, 407411.
Horowitz, G. D., Groeger, J. S., Legaspi, A. & Lowry, S. F. (1985). The response of fibronectin to differing parenteral caloric sources in normal man. Journal of Parenteral and Enteral Nutrition 9, 435438.
Howard, L., Dillon, B., Saba, T. M., Hofmann, S. & Cho, E. (1984). Decreased plasma fibronectin during starvation in man. Journal of Parenteral and Enteral Nutrition 8, 237244.
Ingenbleek, Y., De Visscher, M. & De Nayer, P. (1972). Measurement of prealbumin as an index of protein-calorie malnutrition. Lancet i, 106108.
Japanese Ministry of Health and Welfare (1986). Diagnostic Tables and Figures for Obesity and Emaciation Health Promotion and Nutrition Division, Health Service Bureau, Ministry of Health and Welfare. (In Japanese.) Tokyo: Daiichi Press.
Kasahara, Y. & Ashihara, Y. (1981). Colorimetry of angiotensin-I converting enzyme activity in serum. Clinical Chemistry 27, 19221925.
Komaki, G., Tamai, H., Mori, T., Nakagawa, T. & Mori, S. (1988). Changes in serum angiotensin-converting enzyme in acutely starved non-obese patients: a possible dissociation between angiotensin-converting enzyme and the thyroid state. Acta Endocrinologica 118, 4550.
Kron, L., Katz, J. L., Gorzynski, G. & Weiner, H. (1978). Hyperactivity in anorexia nervosa: a fundamental clinical feature. Comprehensive Psychiatry 19, 433440.
Laurell, C. B. (1966). Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Annals of Biochemistry 15, 4552.
Lombardi, R., Mannucci, P. M., Seghatchaian, M. J., Garcia, V. V. & Coppola, R. (1981). Alterations of factor VIII von Willebrand factor in clinical conditions associated with an increase in its plasma concentrations. British Journal of Haematology 49, 6168.
Matsubayashi, S., Tamai, H., Kobayashi, N., Takaichi, Y., Fukata, Y., Hirota, Y., Kuma, K., Nakagawa, T. & Kumagai, L. F. (1988). Angiotensin-converting enzyme and anorexia nervosa. Hormone and Metabolic Research 20, 761764.
Murata, Y., Ceccarelli, P., Refetoff, S., Horowitz, A. L. & Matsui, N. (1987). Thyroid hormone inhibits fibronectin synthesis by cultured human skin fibroblasts. Journal of Clinical Endocrinology and Metabolism 64, 334339.
Newman, N. M. & Halmi, K. A. (1988). The endocrinology of anorexia nervosa and bulimia nervosa. Endocrinology and Metabolism Clinics of North America 17, 195212.
Palmblad, J., Fohlin, L. & Lundstrom, M. (1977). Anorexia nervosa and polymorphonuclear (PMN) granulocyte reactions. Scandinavian Journal of Haematology 19, 334342.
Prentice, C. R. M., Forbes, C. D. & Smith, S. M. (1972). Rise of factor VIII after exercise and adrenalin infusion, measured by immunological and biological techniques. Thrombosis Research 1, 493506.
Rogers, J. S. II, Shane, S. R. & Jencks, F. S. (1982). Factor VIII activity and thyroid function. Annals of Internal Medicine 97, 713716.
Saba, T. M. (1970). Physiology and physiopathology of the reticulo-endothelial system. Archives of Internal Medicine 126, 10311052.
Saba, T. M. (1986). Plasma and tissue fibronectin: its role in the pathophysiology of the critically ill septic patients. In Critical Care: State of the Art, vol. 7, pp. 437464. [Chernow, B. and Shoemaker, W. C., editors]. Fullerton, CA: Society of Critical Care Medicine.
Saba, T. M., Albert, H. W., Blumenstock, F. A., Evanega, G., Staehler, F. & Cho, E. (1981). Evaluation of a rapid immunoturbidimetric assay for opsonic fibronectin in surgical and trauma patients. Journal of Laboratory and Clinical Medicine 98, 482491.
Saba, T. M. & Jaffe, E. (1980). Plasma fibronectin (opsonic glycoprotein): its synthesis by vascular endothelial cells and role in cardiopulmonary integrity after trauma as related to reticuloendothelial function. American Journal of Medicine 68, 577594.
Scott, R. L., Sohmer, P. R. & MacDonald, M. G. (1982). The effect of starvation and repletion on plasma fibronectin in man. Journal of the American Medical Association 248, 20252027.
Smallridge, R. C., Chernow, B., Snyder, R., Zaloga, G. P. & Burman, K. D. (1985). Angiotensin-converting enzyme activity: potential marker of tissue hypothyroidism in critical illness. Archives of Internal Medicine 145, 18291832.
Tamkun, J. W. & Hynes, R. O. (1983). Plasma fibronectin is synthesized and secreted by hepatocytes. Journal of Biological Chemistry 258, 46414647.
Van Der Heyden, J. T. M., Docter, R., Van Toor, H., Wilson, J. P. H., Hennemann, G. & Krenning, E. P. (1986). Effects of caloric deprivation on thyroid hormone tissue uptake and generation of low-T3 syndrome. American Journal of Physiology 251, E156–E163.
Waterlow, J. C. (1972). Classification and definition of protein-calorie malnutrition. British Medical Journal 3, 566569.
Yamada, K. M. (1983). Cell surface interactions with extracellular materials. Annual Review of Biochemistry 52, 761799.

Keywords

Alterations in endothelium-associated proteins and serum thyroid hormone concentrations in anorexia nervosa

  • Gen Komaki (a1), Hajime Tamai (a1), Toshio Mukuta (a1), Nobuyuki Kobayashi (a1), Kenji Mori (a1), Tetsuya Nakagawa (a1) and Lindy F. Kumagai (a2)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed